ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

When Chinese hamster fibroblasts divide in the presence of halothane there is an increased incidence of cells with abnormal nuclei, both in mitosis and in interphase. The authors compared the effects of halothane and nitrous oxide separately and in combination. Nitrous oxide, 75 per cent, alone had no significant effect compared with controls, less than 1.4 per cent of cells showing abnormalities, while halothane alone had a dose-dependent effect on both phases of the cell cycle. Halothane, 1 percent caused abnormalities in 7 per cent (SEM±0.32) of cells in interphase and in 12 per cent (SEM±0.95) of cells in mitosis, but the combination of 0.75 per cent halothane with 75 per cent nitrous oxide produced 15 per cent (SEM±0.68) abnormal cells in interphase and 22 per cent (SEM±0.51) abnormal mitoses. Similar highly significant differences were obtained throughout the dose-response curves to as much as 4 per cent halothane in air and 2.35 per cent halothane in 75 per cent nitrous oxide. This appears to demonstrate synergism between halothane and nitrous oxide in the production of this particular side effect. In contrast, the effects of halothane and nitrous oxide on growth rate were additive

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

Twenty-four patients with severe, 24 with moderate, and 24 without heart disease were selected for measurements of systolic time intervals (STI) and blood pressure before and during anesthesia. In all patients anesthesia was induced with thiopental, 4 mg/kg. After tracheal intubation. 12 patients from each heart-disease class received halothane–N2O–O2(halothane) and 12 patients from each class morphine–d-tubocurarine–N2O–O2(MS-dTc). Thiopental increased the pre-ejection period (PEP). decreased left ventricular ejection time (LVET). and accelerated heart rate (HR). These changes were similar in patients with and without heart disease. Halothane and MS-dTc lowered systolic blood pressure and increased PEP/LVET. With halothane but not with MS-dTc these changes were more pronounced in patients who had heart disease. Changes of the PEP/LVET ratio during halothane anesthesia were a better discriminating variable among patients without, with moderate, and with severe heart disease than were changes in systolic blood pressure.

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

Lumbar epidural anesthesia was administered to 12 normotensive pregnant ewes. Blood pressure was maintained by intravenous fluid infusion. Six ewes received anesthesia with 1.5 per cent 2-chloroprocaine with 1:100,000 epinephrine and the remaining six received 1.5 per cent 2-chloroprocaine without epinephrine. The sensory level of anesthesia was between the umbilicus and xiphisternum. Except for a transient 14 per cent decrease in uterine blood flow in the ewes receiving 2-chloroprocaine with epinephrine, uterine blood flow remained near control values and was sufficient at all times to maintain stable fetal acid-base and blood gas values. Provided blood pressure and uterine blood flow were stable, the percentage of uterine blood flow distributed to the placenta in the absence of uterine contractions was not altered by epidural anesthesia or by addition of epinephrine to the anesthetic solution.

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

The effectiveness of intravenous administration of dantrolene in prevention and treatment of fulminant malignant hyperthermia (MH) initiated by halothane and succinylcholine (SCh) in genetically susceptible swine was assessed. In six animals, prior administration of dantrolene in doses of 5mg/kg or more prevented MH, while 1 or 3 mg/kg attenuated MH, and 0.1 mg/kg had no effect. In ten additional swine, therapy was not started until MH was fulminant. Five of these were then given supportive therapy only (discontinuation of anesthesia, hyperventilation with oxygen, surface cooling, and NaHCO2). The remainig five received the same supportive therapy, plus dantrolene (7.5 mg/kg). With supportive therapy only, arterial bloodpH, Pco2and Pco2retumed toward normal, but oxygen consumption (VO2), blood lactate, potassium (K*). catecholamines, and temperature continued to increase and the course of MH was unaltered. When dantrolene was added to supportive therapy, VO2, lactate, K*, catecholamines, and temperature decreased, and the course of MH was dramatically slowed and, apparently, reversed.

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

Concentrations of 6-β-hydroxycortisol (6-OHF), a polar metabolite of cortisol formed in the endoplasmic reticulum (microsomes) of the liver, and 17-hydroxyeorticosteroids (17-OHCS) were measured in the urines of six healthy adult male volunteers exposed to a mean of 9.6 MAC-hours of enflurane anesthesia as an index of possible enzyme induction. The ratio of 6-OHF to 17-OHCS in 24-hour urine specimens collected five days before anesthesia was compared with the ratio of these metabolites in 24-hour urine specimens collected 16 to 18 hours after anesthesia. The ratio of 6-OHF to 17-OHCS increased markedly in five and decreased slightly in one volunteer following anesthesia. The results indicate that enflurane may cause induction of hepatic microsomal enzymes.

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0003-3022    

出版商:OVID    

年代:1976

数据来源: OVID