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| 1. |
The History of Neuropeptide Research: Version 5.a |
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Annals of the New York Academy of Sciences,
Volume 780,
Issue 1,
1996,
Page 1-18
ABBA J. KASTIN,
JAMES E. ZADINA,
RICHARD D. OLSON,
WILLIAM A. BANKS,
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摘要:
Two reviews published recently reflect the history of neuropeptide research. One of them1reports the results of a computer search of the scientific literature since 1966. It found more than a quarter of a million papers published concerning those peptides that now are known to be able to exert some effects on the central nervous system (CNS).
ISSN:0077-8923
DOI:10.1111/j.1749-6632.1996.tb15107.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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| 2. |
Transgenic Mice: Preproenkephalin and the Mu Opiate Receptor |
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Annals of the New York Academy of Sciences,
Volume 780,
Issue 1,
1996,
Page 19-28
D. M. DONOVAN,
L. L. MINER,
L. SHARPE,
H. J. CHO,
M. TAKEMURA,
E. UNTERWALD,
F. NYBERG,
M. J. KREEK,
G. R. UHL,
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ISSN:0077-8923
DOI:10.1111/j.1749-6632.1996.tb15108.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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| 3. |
Somatostatin as a Trophic Factor Analysis of Transgenic Mice Overexpressing Somatostatin in Astrocytes |
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Annals of the New York Academy of Sciences,
Volume 780,
Issue 1,
1996,
Page 29-35
JOAN P. SCHWARTZ,
TAKAYUKI TANIWAKI,
ALBEE MESSING,
MICHAEL BRENNER,
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ISSN:0077-8923
DOI:10.1111/j.1749-6632.1996.tb15109.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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| 4. |
CRH Overproduction in Transgenic Mice |
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Annals of the New York Academy of Sciences,
Volume 780,
Issue 1,
1996,
Page 36-48
M. P. STENZEL‐POORE,
J. E. DUNCAN,
M. B. RITTENBERG,
A. C. BAKKE,
S. C. HEINRICHS,
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ISSN:0077-8923
DOI:10.1111/j.1749-6632.1996.tb15110.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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| 5. |
Production of Corticotropin‐releasing Hormone‐deficient Mice by Targeted Mutation in Embryonic Stem Cells |
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Annals of the New York Academy of Sciences,
Volume 780,
Issue 1,
1996,
Page 49-59
LOUIS MUGLIA,
LAUREN JACOBSON,
JOSEPH A. MAJZOUB,
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摘要:
The generation of transgenic mice by introduction of intact or altered genes into the pronuclei of fertilized oocytes has proven a powerful tool in elucidating the consequences of ectopic or tissue‐appropriate overproduction of a given gene product; in defining DNA elements responsible for gene‐specific patterns of temporal, spatial, and regulated transcription; and in targeted oncogenesis for the development of cell culture lines for detailedin vitrostudy. This technology, however, has had limited success in addressing the role and essential function of specific peptides in the intact organism, except in the circumstance in which dominant negative alleles, capable of abrogating function of the normal allele, are available.1,2With the establishment of embryonic stem (ES) cell culture systems amenable toin vitromanipulation for introduction of mutated genes, methods for selection of relatively rare homologous recombination events, and most importantly, the sustained capacity of these ES cells to contribute to the germline of chimeric mice, a method of addressing the consequences of loss of gene function has emerged.3,5Targeted gene inactivation in ES cells with subsequent generation of deficient mice yields inheritable, complete loss of function at all stages of development and in all tissues. This is an advantage when assessing ontogenic importance, ability of interacting systems to compensate for loss of function, and the effects of chronic deficiency. These factors can also impair whole‐organism analysis of function, inasmuch as chronic deficiency may allow up‐regulation of compensatory systems, masking thein vivofunction of the mutation, and global deficiency may make characterization at a specific site of synthesis difficult to determine. Most severely, loss of expression at all stages of development may lead to organism invi
ISSN:0077-8923
DOI:10.1111/j.1749-6632.1996.tb15111.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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| 6. |
Characterization of Corticotropin‐releasing Factor Receptor Subtypesa |
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Annals of the New York Academy of Sciences,
Volume 780,
Issue 1,
1996,
Page 60-80
DIMITRI E. GRIGORIADIS,
TIMOTHY W. LOVENBERG,
DEREK T. CHALMERS,
CHEN LIAW,
ERROL B. DE SOUZA,
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ISSN:0077-8923
DOI:10.1111/j.1749-6632.1996.tb15112.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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| 7. |
Modulatory Actions of Corticotropin‐releasing Factor–binding Proteina |
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Annals of the New York Academy of Sciences,
Volume 780,
Issue 1,
1996,
Page 81-95
DOMINIC P. BEHAN,
ERROL B. DE SOUZA,
ELLEN POTTER,
PAUL SAWCHENKO,
PHILIP J. LOWRY,
WYLIE W. VALE,
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ISSN:0077-8923
DOI:10.1111/j.1749-6632.1996.tb15113.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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| 8. |
Postmortem and Cerebrospinal Fluid Studies of Corticotropin‐releasing Factor in Humansa |
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Annals of the New York Academy of Sciences,
Volume 780,
Issue 1,
1996,
Page 96-105
KELLY M. HARTLINE,
MICHAEL J. OWENS,
CHARLES B. NEMEROFF,
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ISSN:0077-8923
DOI:10.1111/j.1749-6632.1996.tb15114.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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| 9. |
Two Novel Metallopeptidases with a Specificity for Basic Residues Functional Properties, Structure, and Cellular Distributiona |
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Annals of the New York Academy of Sciences,
Volume 780,
Issue 1,
1996,
Page 106-120
THIERRY FOULON,
SANDRINE CADEL,
VALÉRIE CHESNEAU,
MURIEL DRAOUI,
ANNIK PRAT,
PAUL COHEN,
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ISSN:0077-8923
DOI:10.1111/j.1749-6632.1996.tb15115.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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| 10. |
Proenkephalin‐processing Enzymes in Chromaffin Granules |
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Annals of the New York Academy of Sciences,
Volume 780,
Issue 1,
1996,
Page 121-133
VIVIAN Y. H. HOOK,
MARTIN R. SCHILLER,
ANAHIT V. AZARYAN,
NIKOLAOS TEZAPSIDIS,
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ISSN:0077-8923
DOI:10.1111/j.1749-6632.1996.tb15116.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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