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ADVERSE EFFECTS OF THE AMINOSALICYLATES |
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Adverse Drug Reaction Bulletin,
Volume 165,
Issue 1,
1994,
Page 623-626
E Shmueli,
C Record,
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PDF (241KB)
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摘要:
The aminosalicylate group of drugs, used in the treatment of inflammatory bowel disease, has a variety of adverse effects, which include:Common adverse reactionsNausea, vomiting, abdominal pain — Up to 40% with sulphasalazine; much less with mesalazine or olsalazineHeadache — 1–15% with sulphasalazine; less with mesalazine or olsalazineBlood dyscrasias — 1–3% with sulphasalazine Rare with mesalazine or olsalazine.Male intertility — 80% with sulphasalazine, None with mesalazine or alsalazine.Watery diarrhoea — All 5-ASA preparations; obout 15% with olsalazine.Rash fever — 0.5–5% with sulphasalazine; rare with mesalazine or olsalazine.Rare adverse reactionsNephrotoxicity — All drugs. Possibly more common with mesalazine.Pancreatitis — Possibly more common with mesalazine.Exacerbation of coiltis, hepatotoxicity, pulmonary fibrosis, polyarteritis — Very rare with a ninosalicylates.
ISSN:0044-6394
出版商:OVID
年代:1994
数据来源: OVID
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