ISSN:0004-8682    

DOI:10.1111/j.1445-2197.1985.tb00076.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0004-8682    

DOI:10.1111/j.1445-2197.1985.tb00077.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Varied methods of primary surgical treatment of 189 cases of cutaneous malignant melanoma studied in Western Australia had no statistically significant effect on prognosis. The results indicate that wide excision is not justified as the standard treatment of cutaneous malignant melanoma.

ISSN:0004-8682    

DOI:10.1111/j.1445-2197.1985.tb00078.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0004-8682    

DOI:10.1111/j.1445-2197.1985.tb00079.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Two hundred and twenty‐eight patients with advanced testicular cancer were entered into a randomized study of chemotherapy comprising cis‐platinum (P) 20 mg/m2, days 1–5 every 3 weeks for four courses, bleomycin (B) 30 mg weekly for 12 weeks, and vinblastine (V) at either the low dose of 0.15 mg/kg or the high dose of 0.20 mg/kg on days 1 and 2 every 3 weeks for four courses. In this interim analysis, 64 patients were randomized to high dose PVB. Forty‐five (71%) achieved a complete response, and 13 (25%) a partial response. Seventy patients received low dose PVB of whom 50 (71%) achieved a complete response and 16 (23%) a partial response. Thus there is no difference in the efficacy of this combination chemotherapy with respect to the dose of vinblastine, but the low dose schedule was less toxic (particularly to bone marrow). It was also apparent that the response rate varied with the volume of metastatic disease, irrespective of the dose of vinblastine. Patients with low volume metastases had a complete response rate (CR) of 88%, while those with high volume had a CR rate of 60%. In a second randomization, 68 patients achieving CR were randomized to receive either 1 year of further (maintenance) chemotherapy with cis‐platinum and vinblastine, or no further chemotherapy. One of 37 patients (3%) receiving treatment and 2 of 31 patients (6%) not receiving treatment relapsed, with a follow‐up of at least 10 months. Thus maintenance chemotherapy appears not to be necessary in the treatment of advanced testic

ISSN:0004-8682    

DOI:10.1111/j.1445-2197.1985.tb00080.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0004-8682    

DOI:10.1111/j.1445-2197.1985.tb00081.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Cytotoxic chemotherapy does not yet have a service role in the management of invasive carcinoma of the bladder, though the minor palliation achievable in patients with symptomatic recurrent primary or metastatic disease does justify its use in patients whose symptoms are not controlled by standard analgesia. For the future, progress will depend on more intense screening of new drugs in centres specializing in undertaking Phase 2 Trials on patients with measurable metastases. However, there is in addition a need for studies measuring primary tumour response to drugs in combination with radiotherapy which still remains the most active single agent in the non‐surgical treatment of carcinoma of the bladde

ISSN:0004-8682    

DOI:10.1111/j.1445-2197.1985.tb00082.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Twenty‐nine out of 108 patients (26%) were under 1 year of age at the time of surgery for congenital pelviureteric obstruction. The clinical features and diagnosis, management, follow‐up and results in these patients are reviewed. Clinical presentation was usually with an abdominal mass or urinary infection but an increasing number of cases were diagnosed after maternal ultrasonography had shown hydronephrosis. Ultrasonography, together with renal nuclide scan, were considered to be the most appropriate imaging modalities to define anatomy, determine function and document obstruction. Pyeloplasty was carried out successfully in 28 patients (two bilateral) and one patient had a nephrectomy. Sixteen pyeloplasties were managed by a nephrostomy (with or without a stent), the tubes usually being removed 10–12 days postoperatively. Fourteen pyeloplasties were managed by a wound drain only but one required a secondary nephrostomy although eventual recovery was satisfactory. Renal nuclide scan was found to be the most appropriate follow‐up test and the overall results of surgery were satis

ISSN:0004-8682    

DOI:10.1111/j.1445-2197.1985.tb00083.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Sixteen infants with severe ureteric anomalies were admitted to the Paediatric Unit over the years 1980–81. The two principal aims of treatment were firstly, initial resuscitation and the treatment of severe sepsis, thereby mostly avoiding early operative urinary diversion, and secondly to proceed to corrective surgery when the infant was sufficiently recovered. Initial management included resuscitation, intravenous antibiotics, parenteral nutrition, and where necessary bladder drainage by urethral catheter. Peritoneal dialysis was not required. The diagnosis was established by urography and ultrasound. Surgical urinary diversion was performed on only two of the cases, and results from early corrective surgery have been satisfactor

ISSN:0004-8682    

DOI:10.1111/j.1445-2197.1985.tb00084.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Cavernous haemangioma is considered the most common primary orbital tumour. We present three cases of cavernous haemangioma of the orbit presenting with deterioration of vision and painless unilateral exophthalmos. A review of the current literature available is compared with our findings. The diagnostic examinations that are most helpful in deciding that an orbital cavernous haemangioma is present include plain film X‐ray examination of the orbits and sinuses, B‐mode ultrasonography and computerized axial tomography. Each patient underwent a transcranial surgical procedure for removal of the tumour, after pre‐operative evalu

ISSN:0004-8682    

DOI:10.1111/j.1445-2197.1985.tb00085.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY