ISSN:1040-5488    

出版商:OVID    

年代:2003

数据来源: OVID

ISSN:1040-5488    

出版商:OVID    

年代:2003

数据来源: OVID

ISSN:1040-5488    

出版商:OVID    

年代:2003

数据来源: OVID

ISSN:1040-5488    

出版商:OVID    

年代:2003

数据来源: OVID

ISSN:1040-5488    

出版商:OVID    

年代:2003

数据来源: OVID

ISSN:1040-5488    

出版商:OVID    

年代:2003

数据来源: OVID

ISSN:1040-5488    

出版商:OVID    

年代:2003

数据来源: OVID

摘要:

Introduction.Donohue’s syndrome, also known as Leprechaunism, is a rare autosomal recessive disease that manifests at birth with symptoms of endocrine dysfunction. Metabolic characteristics of the disease include postprandial hyperglycemia, fasting hypoglycemia, insulin resistance, hyperinsulinemia, and failure to thrive. The physical features most often associated with this condition include hypertrichosis, pachyderma, acanthosis nigricans, prominent genitalia, and elfin-like facial characteristics of prominent eyes, wide nostrils, thick lips, and large, low-set ears. Not only is this syndrome rare, but it often results in infant and early childhood mortality. The literature regarding ocular manifestations is limited.Case Report.We present a case of a 29-year-old male with Donohue’s syndrome and significant ocular findings including a subluxated mature cataract, retinal detachment, high myopia, and optic atrophy.Discussion.These ocular sequelae are discussed with regard to the noted endocrine dysfunction and its effects on tissue development and growth.

ISSN:1040-5488    

出版商:OVID    

年代:2003

数据来源: OVID

摘要:

Background.A uveal melanoma is the most common primary intraocular malignancy and is the primary intraocular disease that can be fatal in adults. Until recently, data were limited regarding growth characteristics and at what stage metastases are likely to occur.Case Report.A 49-year-old white male presented on January 19, 1989, for a second opinion regarding a spot that had been discovered in the right eye 13 months prior. Ophthalmologic evaluation and echography were consistent for a uveal melanoma of 5 mm elevation and 13.5 × 6 mm in diameter. The patient refused treatment or enrollment into the Collaborative Ocular Melanoma Study. On December 9, 1991, the eye was enucleated with a modified exenteration due to severe proptosis, tumor thickness of 22 mm, and three areas of extrascleral extension. The patient refused postoperative radiation treatment and refused clinical follow-up. This case was reviewed from the initial evaluation date through the last clinical visit. The patient was recently interviewed with respect to his use of homeopathic medicine, change in lifestyle, and the effect he felt it might have had on his life.Discussion.The literature published by the Collaborative Ocular Melanoma Study regarding the histopathologic characteristics of eyes enucleated and the initial mortality findings of a large choroidal melanoma indicate that this is a most unusual case. The patient has defied the mortality findings of the most recent and largest study to date (mean survival rate, 82 months). The patient is still alive 181 months after the original finding of the lesion and refusal of advised treatment recommendations in favor of homeopathic medicine.

ISSN:1040-5488    

出版商:OVID    

年代:2003

数据来源: OVID

摘要:

Transcranial magnetic stimulation (TMS) is a novel and powerful probe to study the relationship between human brain function and behavior. TMS is being widely used to investigate memory, language, attention, learning, and motor function and is even being utilized therapeutically in the treatment of depression. Some of the earliest applications of TMS have been directed toward the investigation of human visual perception. For example, a strong TMS pulse delivered to the occipital cortex in a sighted or even blind individual can evoke the sensation of perceiving light (visual phosphenes). TMS can also be used to suppress visual perception and investigate the timing of visual information processing. Furthermore, the functional connectivity between different brain areas can be mapped using TMS, thus establishing a causal link between visual cortical function and visual perception. The present article is meant as an overview of the technique of TMS and a review of the literature as it pertains to the study of visual function. The application of TMS in the diagnosis as well as possible therapeutic use in various visual disorders is also discussed.

ISSN:1040-5488    

出版商:OVID    

年代:2003

数据来源: OVID