ISSN:1040-5488    

出版商:OVID    

年代:2001

数据来源: OVID

ISSN:1040-5488    

出版商:OVID    

年代:2001

数据来源: OVID

ISSN:1040-5488    

出版商:OVID    

年代:2001

数据来源: OVID

ISSN:1040-5488    

出版商:OVID    

年代:2001

数据来源: OVID

ISSN:1040-5488    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Background.Postpartum thyroid disease presents in two forms: postpartum thyroiditis (PPT) and postpartum Graves’ disease (PPGD).Case Report.A case of postpartum thyroid dysfunction with ophthalmopathy is presented.Discussion.In women diagnosed with Graves’ disease during the ages of 20 to 35 years, 66% have a postpartum onset; women with a previous history of Graves’ disease frequently relapse in the postpartum period. Additionally, up to 25 to 30% of postpartum women can develop permanent hypothyroidism from postpartum thyroiditis. The signs and symptoms of PPT and PPGD may be indefinite after delivery and often go undiagnosed. Because complications can be significant and may become irreversible, proper diagnosis and timely treatment is important.

ISSN:1040-5488    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Purpose.The purpose of this case series is to show photographically the varying clinical appearance of granular corneal dystrophy in three generations of one family and to review the genetic basis of this and related conditions.Case Series.We present cases for four affected individuals along with slitlamp biomicroscopic photographs.Discussion.A review of the photographs and the literature suggests that the abnormal keratoepithelin first appears in the superficial cornea as faint subepithelial opacities. With time, these become arranged in the curved lines of a vortex pattern, after which the deposits become scattered in no particular pattern and at all levels of the cornea. In this family, corneal erosions are a regular feature. Mutations of the gene coding for keratoepithelin (&bgr;ig-h3) may give rise to variable clinical manifestations.

ISSN:1040-5488    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Background.All currently approved glaucoma medications are directed toward lowering intraocular pressure. However, it is apparent that there are pressure-independent mechanisms associated with the development of glaucomatous optic neuropathy. There has been considerable effort to develop therapeutics that rescue the retinal ganglion cells from undergoing secondary degeneration after the original insult has occurred. This therapeutic strategy has been termed neuroprotection.Methods.The literature was reviewed to examine the current knowledge of the degenerative cascade involved in glaucomatous damage, with emphasis on potential therapeutic targets for neuroprotective strategies.Results.There are a number of promising areas of research for new glaucoma therapies including glutamate antagonists, calcium channel blockers, antioxidants, nitric oxide synthase inhibitors, neurotrophins, and anti-apoptotic agents.Conclusions.Glaucoma is a complex disease with a number of risk factors and mechanisms leading to ganglion cell death. Future glaucoma therapy will likely include neuroprotectants that could be used as an adjunct therapy with other medications designed to lessen the initial insult (i.e., intraocular pressure–lowering compounds). As the word neuroprotection becomes more popular, care must be taken in evaluating the research literature for clinically effective therapies.

ISSN:1040-5488    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Purpose.To determine whether the eyes of high-Dk soft contact lens wearing subjects can be discriminated from non–contact lens wearing subjects.Methods.This study was a prospective masked assessment of 32 subjects, 16 of whom wore experimental high-Dk soft contact lenses and 16 of whom did not wear contact lenses. Subjects wore high-Dk lenses on a 30-night replacement schedule for an average of 9 months. Tear film characteristics, staining and vascularization of the cornea, conjunctival staining, and the presence of microcysts in the corneal epithelium were assessed using slitlamp microscopy. The endothelium was examined for polymegethism.Results.No differences were found between the two groups in any of the variables that were examined (p > 0.05) except that the high-Dk lens wearing group had about twofold more tear film debris and 2.5-fold more severe conjunctival staining (p < 0.05).Conclusions.Hypoxia-associated effects were not apparent in the eyes of subjects wearing experimental high-Dk soft contact lenses. Conjunctival staining can generally distinguish lens wearers from non–lens wearers and can be used to discriminate between high-Dk lens wearing subjects and non–lens wearing subjects.

ISSN:1040-5488    

出版商:OVID    

年代:2001

数据来源: OVID

摘要:

Purpose.To compare the bacterial colonization of soft contact lenses in subjects for successively increasing periods, up to 13 nights of wear. The aim of this study was to determine whether increasing the length of lens wear predisposed subjects to high levels of microbial colonization of lenses.Methods.Subjects (N = 20) were divided into those with a prior history of adverse events (N = 6), Gram-negative bacterial carriers (N = 6), and those with no previous history (N = 8).Results.There were no temporal changes in microbial colonization of lenses. Lenses from all wearers were colonized at least once during the study by Gram-positive bacteria at low numbers (<10 cfu/ml). Gram-negative bacteria colonized lenses at least once in 80% of all wearers. Lenses from Gram-negative bacterial carriers were more frequently colonized byStaphylococcus aureus and Pseudomonassp. compared with subjects with no previous history and subjects with a prior history of adverse events, respectively. Lenses from Gram-negative bacterial carriers were less frequently colonized by a range of Gram-positive bacteria compared with subjects with a prior history of adverse events.Conclusions.Increasing the length of lens wear up to 13 nights did not result in a predictable increase in bacterial colonization of contact lenses. Gram-positive bacteria were isolated frequently but in low numbers, whereas Gram-negative bacteria were present sporadically.

ISSN:1040-5488    

出版商:OVID    

年代:2001

数据来源: OVID