ISSN:0161-3499    

DOI:10.1111/j.1532-950X.1989.tb01048.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Wound healing in five dogs and five cats affected with a connective tissue dysplasia resembling Ehlers‐Danlos syndrome of humans was compared with wound healing in 10 nonaffected animals. Six skin incisions on the lateral aspects of the thorax and abdomen of each animal were sutured and assessed daily for 75 days for evidence of healing. All wounds in non‐affected dogs, affected cats, and nonaffected cats healed by first intention. Three incisions in affected dogs had dehiscence of all or part of the incision line and healed by granulation, contraction, and epithelialization. Biopsies taken at 3, 6, 9, 12, 15, and 75 days were compared histologically to determine if there were any differences in rates of healing between affected and nonaffected animals. Epidermal thickening and scab formation were noted at days 3 and 6 in both affected and nonaffected animals. Infiltration with mononuclear cells and fibroplasia steadily increased from day 6 to day 15 in all groups. Collagen fibril formation was evident by day 9. At day 75, incision sites were recognized by fine, more compact collagen bundles and lack of adnexal structures, as compared with the adjacent dermis in both affected and nonaffected animals. Although delayed wound healing has been reported to be a complication of Ehlers‐Danlos syndrome in humans, using clinical and histologic criteria, wound healing in dogs and cats with Ehlers‐Danlos syndrome appears to be similar to nonaffected

ISSN:0161-3499    

DOI:10.1111/j.1532-950X.1989.tb01049.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The biomechanical properties of wounded and nonwounded skin were studied in three dogs and three cats affected with type I Ehlers‐Danlos syndrome. Three nonaffected dogs and one nonaffected cat served as controls. Samples of wounded skin and adjacent normal skin were harvested at days 75, 138, 141, 144, 147, and 150. Samples were subjected to uniaxial tensile strength testing. Tensile strength, energy absorbed, and site of failure were recorded. In the dogs with Ehlers‐Danlos syndrome, there was an increase in tensile strength in samples containing a scar over adjacent intact skin. In nonaffected dogs, affected cats and the nonaffected cat, the nonwounded skin samples had greater tensile strength. The energy absorbed by the skin samples during testing was highly correlated with tensile stren

ISSN:0161-3499    

DOI:10.1111/j.1532-950X.1989.tb01050.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Effects of desmopressin acetate (1‐desamino‐8‐D‐arginine vasopressin [DDAVP]) on plasma von Willebrand factor (vWf) were studied in 12 purebred Doberman pinschers confirmed to have von Willebrand's disease (vWd) (plasma vWf antigen [vWf:Ag]concentrations,<30 U/dl). Twelve dogs had subnormal plasma botrocetin cofactor (BCf) activity and 11 dogs had prolonged buccal mucosa bleeding times. Tranquilization of three dogs with lenperone and three dogs with xylazine did not induce significant changes in mean plasma vWf:Ag concentrations or mean BCf activities. Thirty and 120 minutes after administration of DDAVP (1 μg/kg subcutaneously), there was significant shortening of the mean buccal mucosa bleeding time. Ten dogs responded to DDAVP with increases in BCf activity which exceeded 10 U/dl at 30 or 120 minutes, or both, after the drug was administered. At the same time, increases in plasma vWf:Ag concentrations were smaller than the increases in BCf activity. It was shown by multimeric analysis that primarily the higher molecular weight forms of vWf increased in plasma in response

ISSN:0161-3499    

DOI:10.1111/j.1532-950X.1989.tb01051.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Splenectomy was performed in 15 crossbred dogs; hilar vessel ligation was used in eight dogs (group 1) and splenic and short gastric artery ligation were used in seven (group 2). Blood flow to six sites along the greater and lesser curvatures of the stomach was recorded with radioactive tracer microspheres. A significantly higher blood flow was recorded in group 2 for the site supplied by the right gastroepiploic artery (p = 0.0441). There was no difference between the groups for the site supplied by the left gastroepiploic and short gastric arteries. Histologically, there was no difference in gastric tissue samples from four sites. Splenic and short gastric artery ligation did not compromise stomach blood flow or the integrity of the stomach wall, and may be superior for splenectomy because of its relative simplicity and potentially shorter operative time.

ISSN:0161-3499    

DOI:10.1111/j.1532-950X.1989.tb01052.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Humeroulnar subluxation was treated surgically in 13 dogs with 18 affected elbows using a proximal osteotomy of the ulna that allowed the ulna to elongate dynamically. Distal humeroulnar subluxation was secondary to premature closure of the distal ulnar physis in 16 elbows. One distal subluxation was secondary to a radioulnar synostosis, and one proximal subluxation developed after premature closure of the distal radial physis. The mean follow‐up time was 22 months. Twenty‐eight percent of the elbows were judged to have excellent results, 22% good results, 50% fair results, and none was judged to have a poor outcome. The presenting lameness grade and the severity of preoperative and postoperative humeroulnar subluxation had significant correlations with the prognosis. Associated orthopedic abnormalities and complications of concurrent surgical procedures affected the outcome in several dogs. Overall, the dynamic proximal ulnar osteotomy was a simple and effective technique for the treatment of uncomplicated humeroulnar subluxat

ISSN:0161-3499    

DOI:10.1111/j.1532-950X.1989.tb01053.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

A cranially hinged laminotomy of vertebra C2was used to expose the cervical spinal cord of a dog with a meningioma in the region of the atlantoaxial articulation. By preserving the dorsal atlantoaxial ligament, the technique seemed to result in greater and more physiologic stability between the atlas and axis than dorsal laminectomy and prosthetic replacement of the dorsal atlantoaxial ligament. The procedure allowed a dorsal approach, avoiding injury to the vertebral arteries and limited exposure, which are potential problems with hemiiaminectomy of C1‐C2. Further investigation is needed to evaluate long‐term consequences of this proced

ISSN:0161-3499    

DOI:10.1111/j.1532-950X.1989.tb01054.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0161-3499    

DOI:10.1111/j.1532-950X.1989.tb01055.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The blood supply to the descending colon of the horse was studied by gross dissection and methyl methacrylate corrosion casts. The arterial supply is derived from the left colic artery and cranial rectal artery with the left colic artery supplying approximately the proximal three fourths. Each artery gives off four to eight arcuate arteries that form a series of anastomosing arcades. The arcade pattern continues to form a marginal artery that parallels the long axis of the colon. Small branches from the marginal artery anastomose with adjacent branches to form a secondary arcade. The secondary arcade lies approximately 1 cm proximal to the mesenteric teniae and sends off long arteries at regular intervals that course circumferentially around the bowel. The long arteries begin under the serosal mesothelium and perforate the muscular layers to course in the submucosal layer. The long arteries branch off supplying the wall of the colon and arborize over the antimesenteric surface, anastomosing with the vessels from the opposite side. The result is the formation of a series of vascular rings surrounding the colon. Venous return, in general, parallels the arterial supply.

ISSN:0161-3499    

DOI:10.1111/j.1532-950X.1989.tb01056.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

To compare the effects of placing enterotomy incisions on or off the antimesenteric teniae and closing the intestinal mucosa as a separate layer, four longitudinal enterotomies were performed in the descending colon of each of six horses by the following techniques: incision through the antimesenteric teniae with oneand two‐layer closure, and incision adjacent to the teniae with oneand two‐layer closure. The horses were necropsied at day 33 for evidence of obstruction, adhesions, and ultrasonographic determination of the percent reduction in lumen diameter. Histologic and histomorphometric evaluations included: inflammatory response in the mucosal and seromuscular layers, mucosal atrophy or degeneration, alignment of the incision edges, area of fibrosis, and distance between the incised muscle edges. Adhesions were present in 5 of 24 enterotomies. Incisions adjacent to the teniae resulted in narrower lumen diameters than incisions through the teniae. Inflammatory response was greatest in incisions adjacent to the teniae with two‐layer closure. Closure of the mucosa as a separate layer had no effect on any of the parameters evaluated. Enterotomies through the antimesenteric teniae were more easily performed, resulted in less hemorrhage, and maintained a larger lumen diameter than those performed adjacent to the t

ISSN:0161-3499    

DOI:10.1111/j.1532-950X.1989.tb01057.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY