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21. |
Why is Parity Protective for Uterine Fibroids? |
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Epidemiology,
Volume 14,
Issue 2,
2003,
Page 247-250
Donna Day Baird,
David Dunson,
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PDF (164KB)
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摘要:
Uterine fibroids are benign tumors, the etiology of which is not understood. Symptoms can be debilitating, and the primary treatment is surgery, usually hysterectomy. Epidemiologic data show that pregnancy is associated with reduced risk of fibroids. We hypothesize that this association is attributable to a protective effect of postpartum involution of the uterus. After each pregnancy the uterus rapidly returns to prepregnancy size by dramatic remodeling of the tissue. We hypothesize that small fibroids are eliminated during this process. We present preliminary epidemiologic evidence that is consistent with this hypothesis. If the hypothesis is supported by more direct evidence, it may have broader implications, supporting the idea that tissue remodeling may be a general mechanism for limiting tumor development.
ISSN:1044-3983
出版商:OVID
年代:2003
数据来源: OVID
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22. |
Placental Genes and Breast Cancer: Can the Offspring’s or Father’s Genotypes Predict Mother’s Risk? |
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Epidemiology,
Volume 14,
Issue 2,
2003,
Page 251-253
Habibul Ahsan,
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PDF (124KB)
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摘要:
Half of the placental genes to which a woman is exposed during pregnancy come from her mating partner. Placental hormones, especially human chorionic gonadotropin and human placental lactogen, are considered to mediate the protective effects of full-term pregnancy and lactation on breast cancer risk. In this paper, variants in a woman’s placental human chorionic gonadotropin or human placental lactogen genes, which are easily measurable through her offspring’s genotypes, are associated with her breast cancer risk. If this hypothesis is true it would indicate that genotype of a woman’s mating partner can affect her breast cancer risk and that offspring’s genotype may be useful in predicting such risk. Because the placenta produces a wide range of hormones and enzymes (in addition to human chorionic gonadotropin and human placental lactogen), results supporting this hypothesis could open new dimensions to genetic research for diseases beyond breast cancer (including gynecologic tumors and reproductive and pregnancy-related disorders).
ISSN:1044-3983
出版商:OVID
年代:2003
数据来源: OVID
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23. |
Banking of Urine Sediments as DNA Source in Epidemiologic Studies |
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Epidemiology,
Volume 14,
Issue 2,
2003,
Page 254-255
Karen Steinberg,
Deborah Nickerson,
Michele Caggana,
Margaret Gallagher,
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ISSN:1044-3983
出版商:OVID
年代:2003
数据来源: OVID
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24. |
Erratum |
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Epidemiology,
Volume 14,
Issue 2,
2003,
Page 255-255
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ISSN:1044-3983
出版商:OVID
年代:2003
数据来源: OVID
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