摘要:

Testing the reliability and usefulness of disability scales in Parkinson''s disease has been the object of a study carried out by 4 neurologists on 48 patients using 2 rating scales – Hoehn and Yahr staging and Columbia University Rating Scale – and 2 disability scales – Northwestern University Disability Scale and Extensive Disability Scale, a new scale conceived for this purpose, which is more accurate in examining in a different way the physical incapacity and handicap of parkinsonian patients in their daily living. The examiners worked in pairs and did not discuss their rating scores before the end of the study. As far as interobserver agreement is concerned, the results of the disability scales are better than those of the rating scales. The Northwestern Disability Scale and the new scale are similar in reliability and consistency; however, the Extensive Disability Scale has proved to be a better indicator of the functional status. We suggest a more extensive employment of disability scales in clinical st

ISSN:0251-5350    

DOI:10.1159/000110285

出版商:S. Karger AG    

年代:1991

数据来源: Karger

摘要:

In some multiple-case families, dementia of the Alzheimer type (DAT) is very likely to be of a genetic origin. Nevertheless, most DAT cases are sporadic and a disease with a majority of sporadic cases is usually of environmental origin. Are there two different etiologies of DAT? And if so, what is the proportion of genetic cases? We describe a model designed to assess the genetic risk in DAT. Our basic hypotheses were: (1) DAT could be of either genetic or environmental origin; (2) in its genetic form, transmission is of the autosomal dominant type, and (3) a proportion (π) of the population is exposed to environmental risk. We have estimated the value of the probability (π) of being exposed to the environmental risk and of the gene frequency (p). These values were highly dependent on the model assumptions, but non-inherited cases were consistently more frequent than inherited one

ISSN:0251-5350    

DOI:10.1159/000110286

出版商:S. Karger AG    

年代:1991

数据来源: Karger

摘要:

Using the unique resources of the Rochester Epidemiology Project for population-based studies, we identified 629 Olmsted County, Minn., residents who fulfilled the 1988 International Headache Society criteria for newly diagnosed migraine over a 3-year period. Over 6,400 patient records from several diagnostic rubrics were screened; a substantial proportion of cases had been ''signed-out'' to diagnoses other than ''migraine headache''. Medical records were reviewed by two trained nurses who abstracted supporting data for two neurologists. The neurologists determined whether each case met eligibility requirements and assigned a headache diagnosis by consensus. The diagnostic criteria offered some flexibility and were adapted to retrospective record-based research. Most records contained enough information to effectively classify the headache, although information on the frequency and duration of attacks proved to be problematic. A validation re-abstraction of a 10% sample of cases was undertaken with acceptable reproducibility of symptoms and diagnosis. Our study shows that migraine headache can be studied retrospectively through existing detailed medical records.

ISSN:0251-5350    

DOI:10.1159/000110287

出版商:S. Karger AG    

年代:1991

数据来源: Karger

ISSN:0251-5350    

DOI:10.1159/000110288

出版商:S. Karger AG    

年代:1991

数据来源: Karger

ISSN:0251-5350    

DOI:10.1159/000110289

出版商:S. Karger AG    

年代:1991

数据来源: Karger

ISSN:0251-5350    

DOI:10.1159/000110290

出版商:S. Karger AG    

年代:1991

数据来源: Karger

ISSN:0251-5350    

DOI:10.1159/000110291

出版商:S. Karger AG    

年代:1991

数据来源: Karger

ISSN:0251-5350    

DOI:10.1159/000110292

出版商:S. Karger AG    

年代:1991

数据来源: Karger