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11. |
Parkinson's Disease in Kin-Hu, Kinmen: A Community Survey by Neurologists |
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Neuroepidemiology,
Volume 13,
Issue 1-2,
1994,
Page 69-74
S.J. Wang,
J.L. Fuh,
C.Y. Liu,
K.P. Lin,
R. Chang,
J.S. Yih,
P. Chou,
K.N. Lin,
E.L. Teng,
E.B. Larson,
A.B. Graves,
H.C. Liu,
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摘要:
A door-to-door survey by neurologists in Kin-Hu township, Republic of China, of a sample of the Chinese population of 683 persons aged 50 years and over was performed in August, 1992. A total of 482 subjects (70.6%) completed the study. Kin-Hu, a township of Kinmen, is predominantly rural with agriculture as the main occupation. Six subjects (5 men, 1 woman) were diagnosed with Parkinson''s disease (PD). Of these six, five were newly diagnosed; one of the five also had dementia. The crude prevalence rate per 1,000 persons over 50 years of age of PD in Kin-Hu was 6.2. The age-specific prevalence rates per 1,000 persons (95% confidence intervals) were 0 for age 50–59, 7.8 (0–22.9) for age 60–69, 17.5 (5.2–29.8) for age 70–79, and 25.4 (10.9–39.9) for age ≧ 80. These rates are considerably higher than those reported in the People''s Republic of China, and similar to rates found in Western countries. The higher prevalence of PD found in this pilot study suggests that environmental factors may be more important than racial factors in the pathogenesis of PD. If confirmed, the results suggest that epidemiologic studies looking for environmental risk factors migh
ISSN:0251-5350
DOI:10.1159/000110361
出版商:S. Karger AG
年代:1994
数据来源: Karger
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12. |
Anticipation in Myotonic Dystrophy: A Parental-Sex-Related Phenomenon |
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Neuroepidemiology,
Volume 13,
Issue 1-2,
1994,
Page 75-78
A.L. López de Munain,
A. Blanco,
J.I. Emparanza,
J.F. Martí Massó,
A. Cobo,
B. Basauri,
L. Martorell,
M. Baiget,
J.M. Martínez Lage,
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摘要:
We report anticipation in an extensive sample of myotonic dystrophy (MyD) kindreds taken from an epidemiological survey recently conducted in Guipúzcoa, Spain. Analysis of the parent-child pairs ascertained showed a mean anticipation of 2.86 decades (range 0–6). Greater anticipation occurred when the transmissor parent was the mother. These results suggest a possible sex-related effect in the transmission of the MyD gene, and are in agreement with recent discoveries at the molecular lev
ISSN:0251-5350
DOI:10.1159/000110362
出版商:S. Karger AG
年代:1994
数据来源: Karger
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