摘要:

There is mounting epidemiologic evidence to support the relationship of lipids as a risk factor for ischemic stroke. We review epidemiologic and pathophysiologic evidence for such a link. Treatment of hyperlipidemia is addressed within the context of overall cardiovascular disease risk but also for stroke prevention.

ISSN:0251-5350    

DOI:10.1159/000109679

出版商:S. Karger AG    

年代:1997

数据来源: Karger

摘要:

The purpose of this study was to assess the contributions of period and birth cohort effects to changes in cerebrovascular disease (CVD) mortality in Spain over the period 1955–1992. Poisson regression models were fitted to age- and sex-specific CVD mortality rates obtained from National Vital Statistics. In the period 1955–1975, CVD mortality remained stable. In the period 1975–1992, CVD mortality declined by 54% (rate ratio, RR: 0.46; 95% confidence interval, Cl: 0.43–0.49) in males and 62% (RR: 0.38; 95% Cl: 0.34–0.42) in females. The cohort effect was very small up to the generation born in 1905, moving clearly downward thereafter. CVD mortality for subjects born in the period 1945–1949 was lower than for those born in the period 1905–1909 by 68% (RR: 0.32; 95% Cl: 0.16–0.63) in males and 82% (RR: 0.18; 95% Cl: 0.07–0.45) in females. Among the possible partial explanations for these effects are the decline in ischemic heart disease and rheumatic fever mortality, the drop in salt and alcohol intake, the reduction in smoking among males and blood pressure among females, and the widespread use of antihypertensive treatments in Spain over

ISSN:0251-5350    

DOI:10.1159/000109680

出版商:S. Karger AG    

年代:1997

数据来源: Karger

摘要:

Essential tremor (ET) is the most prevalent movement disorder. It is unknown to what extent ET clusters within families, and the role of genetic susceptibility in the etiology of ET has not been adequately investigated at the population level. The problem is largely methodological, with few well-designed studies. The Washington Heights-lnwood Genetic Study of ET, begun in 1995, is designed to investigate the genetics of ET using a methodology that has not been applied to ET research to date. Part of the design includes a new set of clinical and electrophysiological diagnostic criteria for ET; the present paper describes this novel study design.

ISSN:0251-5350    

DOI:10.1159/000109681

出版商:S. Karger AG    

年代:1997

数据来源: Karger

摘要:

We estimated survival of patients with early onset Alzheimer’s disease (AD) or vascular dementia (VaD) presenting to psychiatric hospitals in Scotland (1974–1988) and related this to age, gender and socio-economic variables. Hospital records of 1794 early onset dementia patients were reviewed. We identified 451 patients with early onset AD and 384 with VaD. Survival to death was calculated from symptom onset and presentation. Small geographical areas (postcode sectors) were classified by urban/rural category and deprivation score. Five-year survival from presentation of early onset AD was 32% for men and 43% for women compared to 22% for men and 36% for women with VaD. We conclude that increased age at presentation was associated with shorter survival in early onset AD and VaD. Socio-economic deprivation was associated with longer survival in VaD. The effects of urban/rural score were accounted for by the major effects of socio-economic deprivat

ISSN:0251-5350    

DOI:10.1159/000109682

出版商:S. Karger AG    

年代:1997

数据来源: Karger