摘要:

Percutaneous radiofrequency cordotomy to relieve intractable pelvic pain in 10 patients with cervical cancer caused little morbidity, had a low incidence of permanent complications (usually urinary retention and respiratory problems) and could be repeated. High and low cervical percutaneous cordotomy was beneficial in all patients investigated and their pain-free interval lasted from 6 to 29 months. This procedure with destruction of the lateral spino-thalamic tract at C-2 or C-5-C-6 with resultant contralateral loss of superficial pain, temperature, deep and visceral pain below these levels has proven to be of distinct benefit to patients with intractable pelvic pain secondary to cervical cancer.

ISSN:0029-7844    

出版商:OVID    

年代:1972

数据来源: OVID

摘要:

A number of reports have indicated that a hemophilia-like disease associated with pregnancy and the postpartum period is caused by a circulating anticoagulant directed against Factor VIII (antihemophilic globulin). This communication reports the clinical and laboratory findings of a primigravida who developed a hemorrhagic diathesis in association with such an anticoagulant. This anticoagulant was unique in that it was found in the patient's plasma prior to delivery. The inhibitory activity to Factor VIII was initially found in the IgM fraction, but analysis of subsequent plasma samples revealed a shift to the IgG fraction. The patient was managed successfully throughout delivery and the puerperium with infusions of Factor VIII concentrate sufficient to overcome the effect of the inhibitor.

ISSN:0029-7844    

出版商:OVID    

年代:1972

数据来源: OVID

摘要:

Ritodrine hydrochloride infused intravenously at increasing rates of 100 to 300 μg/min inhibited uterine contractility completely in 5 of 6 premature labors. Effective inhibition of the intensity of uterine contractions, which had been unresponsive to other treatments, makes ritodrine a valuable synergetic agent in the combined treatment of premature labor, when single agents fail. A moderate increase in heart rate and pulse pressure suggests an increased cardiac output and placental perfusion during treatment with ritodrine.

ISSN:0029-7844    

出版商:OVID    

年代:1972

数据来源: OVID

摘要:

Cervical fistulas which apparently resulted from midtrimester abortions have been described in 4 patients. These fistulas are difficult to diagnose and to repair; In 3 of the 4 patients repeated surgical attempts were required. Because all of the patients were symptomatic, it is possible that there are other asymptomatic postabortal women harboring similar fistulas.

ISSN:0029-7844    

出版商:OVID    

年代:1972

数据来源: OVID

摘要:

In an effort to lower the incidence and severity of neconatal jaundice, 96 mothers were each given 20 mg of phenobarbital each night, beginning at the thirty-second week of gestation. Previous reports have suggested that such treatment stimulates the glucuronyl transferase system in the fetal liver and lowers the incidence of hyperbilirubinemia in the newborn. Serum bilirubin levels during the first four days of life were compared with those of 114 control mothers and infants. Treatment lowered the mean neonatal bilirubin at 72 hours after birth from 8.5 to 6.4 mg%. While 24.6% of control infants had serum bilirubin levels greater than 10 mg % at 96 hours, only 7.3% of the treated infants had levels greater than 10 mg % at this time. This study concludes that treating mothers with phenobarbital is an effective adjunct in lowering the incidence of neonatal jaundice.

ISSN:0029-7844    

出版商:OVID    

年代:1972

数据来源: OVID

摘要:

Premature labor and delivery of a stillborn infant in whichListeria monocytogeneswas cultured from the fetus, placenta and uterine cavity is reported. The literature concerning infection withL monocytogenesis reviewed, with particular attention to the unusual clinical syndrome of intrauterine infection of the fetus known as miliary granulomatosis or granutomatosis infantiseptica, observed in the case presented. Epidemiology and bacteriologic properties are discussed. The infrequent isolation of this organism is thought to be due to a low index of suspicion and to its resemblance to more commonly isolated, morphologically similar, bacteria.

ISSN:0029-7844    

出版商:OVID    

年代:1972

数据来源: OVID

摘要:

Triple mosaicism of 45, C—/46/47, C+ (most likely XO/XX/XXX) was found in 2 women with history of fetal wastage. One of them also presented with subfertility. Both were of normal phenotypes and had had regular menses. The first patient showed an increased total finger ridge count which is compatible with the finding of an XO cell line. The fetal wastage and subfertility may be explained by the presence of 45, X cells. It is also possible that the presence of 47, XXX cells may give rise to some degree of ovarian dysfunction. Couples with history of subfertility and/or multiple spontaneous abortion should be studied cytogenetically not only to detect balanced structural abnormality but also to search for chromosomal mosaicism.

ISSN:0029-7844    

出版商:OVID    

年代:1972

数据来源: OVID

摘要:

Prenatal genetic studies on amniotic fluid samples obtained early in pregnancy are becoming part of clinical obstetric practice. Most identifiable chromosomal abnormalities and more than 40 biochemical disorders can now be diagnosed in utero, aside from the important fetal sexing in sex-linked diseases. Our experience with 100 consecutive amniotic fluid samples from 94 pregnancies is described. A diagnosis was made from 99% of the amniotic fluids received, with only one sample lost to contamination. Four confirmed affected fetuses were diagnosed prenatally. Abortion followed amniocentesis in 1 case, and a probably unrelated fetal death occurred in another. No errors have become apparent in the outcome of 58 pregnancies. Obstetricians are urged to consider the indications for amnioccntesis for genetic disorders in every patient.

ISSN:0029-7844    

出版商:OVID    

年代:1972

数据来源: OVID

摘要:

A second case is reported in which Lesch-Nyhan syndrome was diagnosed prenatally, pregnancy terminated and the enzyme deficiency in fetal tissues confirmed. A micromethod for H-PRT determination, which could make earlier prenatal diagnosis possible, has been applied to demonstrate the enzyme deficiency in cultured amniotic cells. In contrast to an earlier report, measurable amounts of H-PRT activity were found in the tissues of the affected fetus. The possibility of using the ratio of uric acid to creatinine in amniotic fluid as additional evidence in prenatal diagnosis of the Lesch-Nyhan syndrome is discussed.

ISSN:0029-7844    

出版商:OVID    

年代:1972

数据来源: OVID

摘要:

Combined antithyroid-thyroid drug therapy is not recommended for the pregnant hyperthyroid because: a) the least possible dose of anti-thyroid drug and a full dose of exogenous thyroid are mutually exclusive objectives; b) combined therapy increases the fetus's exposure to antithyroid drug; c) added thyroid changes the source but not the quantity of hormone in the maternal circulation; d) euthyroid mothers do give birth to goitrous or athyrotic cretins, suggesting that normal concentrations of maternal thyroid do not protect the fetus; e) combined therapy complicates treatment unnecessarily; f) management with antithyroid drug alone is satisfactory if the free thyroxine index is used as a guideline, the dose of antithyroid is reduced in anticipation of the improvement that usually occurs as pregnancy advances, and surgery is considered whenever the dose of anti-thyroid drug exceeds 400 mg daily during the third trimester.

ISSN:0029-7844    

出版商:OVID    

年代:1972

数据来源: OVID