摘要:

In an unsclcctcd, consecutive series of 137 midtrimester amniocenteses for prenatal genetic diagnosis, it was found that the incidence of blood contamination of amniotic fluid samples was similar regardless of placenta! site as determined by ultrasound localization. Three (5.8%) patients with anterior placental location versus 5 (9.1%) patients with posterior placentas had gross blood in the amniotic fluid by visual inspection. These results support the view that placenta) penetration during amniocentesis is not the major cause of bloody taps. Ultrasound studies done prior to midtrimester amniocentesis should, perhaps, be more specifically evaluated in relation to pregnancy information obtained rather than solely as an aid to improve technical performance of amniocentesis.

ISSN:0029-7844    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

The use of beta-adrenergic agonists in high-risk pregnancies has shown evidence of favorable effects on the fetus. Intravenous injections of133Xe were given to evaluate the effects of short-term administration of fenoterol (3μg/min) and isoxsuprine (150 jug/ min) on the intervillous and myometrial blood flow in a series of 48 women during the last trimester of pregnancy. Both fenoterol and isoxsuprine treatment increased the maternal heart rate significantly. There was a significant rise in myometrial blood flow when fenoterol was given, but the intervillous blood flow did not change significantly during the administration of either isoxsuprine or fenoterol. Previous oral isoxsuprine treatment did not diminish the cardiac effect of intravenous fenoterol, but the improvement in myometrial blood flow was eliminated. This result indicates that β-adrenergic agonists may have a specific dilatational effect on the myometrial blood vessels. From the heniodynamic point of view, the β-adrenergic a onists have a limited value in the treatment of chronic fetal asphyxia or intrauterine fetal growth retardation.

ISSN:0029-7844    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

Nicotine (0.14–0.25 mg/kg), injected intravenously or intraarterially into conscious pregnant ewes, caused a decrease in fetal Pao2within 5 minutes, persisting for up to 30 minutes. There was a significant fall in the incidence of fetal breathing movements. These changes did not occur if the ewe was treated with an alpha-blocking agent (phentolamine) or if the nicotine was infused for 30 minutes at 0.27 to 0.85 nig/minute. Nicotine crossed the placenta; fetal concentrations equaled those in the ewe 5 minutes after the injection and remained at or above maternal levels for 1 hour. Nicotine given directly to the fetus(0.005–0.03 mg/kg estimated fetal weight) stimulated fetal breathing movements in a dose-related manner. We suggest that the maternal injection of nicotine results in a fall of uterine blood flow by a sympathomimetic action, leading to transient fetal hypoxemia and a reduction of fetal breathing movements and that a similar phenomenon may occur when a pregnant woman smokes cigarettes

ISSN:0029-7844    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

The purpose of (his study was to determine by RIA the concentrations of relaxin in various compartments and tissues in pregnant women. Ten pairs of maternal venous and cord blood were studied. The mean relaxin concentrations, in immunoreactive equivalents of porcine relaxin, were 0.683 ng/ml in maternal serum and 0.009 ng/ml in cord serum. Relaxin was undetectable in 8 of 9 samples of amniotic fluid. Mean concentrations of relaxin, in pg immunoreactive equivalents of porcine hormone per mg protein, from maternal tissues at term pregnancy were as follows: fat 93 (N = 5), myometrium 47 (N = 4), skin 62 (N = 5), placenta 51 (N = 9), and corpus luteum 13,000 (N = 8). These data suggest that little relaxin crosses the placenta and little is produced in the fetus. Contrary to prior suggestions that relaxin may also be a placenta! product, relaxin appears to be solely produced in the corpus luteum, making it the only peripherally measured hormone that can be used as an index of lutcal activity in pregnancy.

ISSN:0029-7844    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

This study was designed to assess the effect of long-term treatment with three combined oral contraceptives (OC) on the gonadotropin response to LHRH. The release of LH and FSH after a single 50-μg dose of LHRH was studied from Days 11 to 14 of treatment and Days 2 and 3 after discontinuation of the treatment. The responses were compared with controls during the luteal phase (Days 16 to 19) of the menstrual cycle. LH and FSH baseline levels and release after LHRH injection were markedly depressed in women on OC treatment. The patterns of gonadotropin response after LHRH, however, were similar to the responses during the luteal phase. Following discontinuation of OC treatment, the basal levels of LH and FSH and the response to LHRH continued to be depressed, with a further decrease in the FSH release. These results indicate that treatment with combined OC exert a significant depression on the release of gonadotropins.

ISSN:0029-7844    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

The observation of the “Peak” mucus symptom in women using the ovulation method of natural family planning has been correlated with the estimated time of ovulation, as evaluated by indirect hormonal parameters. In 65 cycles of the 73 studied in 24 patients, there was hormonal confirmation of ovulation; in eight cycles, anovulation or luteal dysfunction was suspected. In the 65 normal cycles, 64 exhibited a Peak symptom. In those cycles, ovulation was estimated to occur from 3 days before to 3 days after the Peak symptom with a mean of 0.31 days before the Peak symptom. In 95.4% of these cycles, ovulation was estimated to occur from 2 days before to 2 days after the Peak symptom. The variation between cycles of the same patient ranged from 0 to 4 days with a mean of 1.8 days. The beginning of the mucus symptom preceded the estimated time of ovulation by an average of 5.9 days.

ISSN:0029-7844    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

Sixty-four women with primary dysmenorrhea participated in a double-blind, parallel trial of naproxen sodium versus placebo during three menstrual cycles. Comparative measures employed to assess the efficacy of the medications included changes in pain intensity during each dysmenorrheic episode, the degree of pain relief afforded, the necessity of using a supplementary analgesic, and the extent to which medication enabled the patients to continue their daily activities unimpeded. By these measures, naproxen sodium was significantly superior as compared to the placebo. Particularly striking was the fact that of 22 naproxen sodium treated women who historically had to stay at home from work and/or in bed, only 5 remained incapacitated compared with 21 of 26 patients of the placebo group. Only 1 patient experienced side effects (nausea and hypomenorrhea) from naproxen sodium.

ISSN:0029-7844    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

To improve the method for identification of Mycoplasma as a cause of unexplained infertility and to test whether mycoplasmal endometritis could be responsible for reproductive failure, successful endometrial jet washing technique was performed on 59 infertile patients. Sixteen patients (27%) showed positive Mycoplasma growth. Five patients (31%) from this group became pregnant within a few months following an antibiotic treatment. These results were compared with 50 control patients and only 3 (6%) showed positive Mycoplasma growth from endometrial washings. The data reported in this paper support the concept that endometritis due to Mycoplasma of T-strain or hominis can be a cause of infertility.

ISSN:0029-7844    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

The present study reviews the pregnancy outcome or 99 patients treated with salpingostomy techniques for distal flmbrial obstruction. Eighty-seven patients were treated with terminal salpingostomy, 10 with medioampullary salpingostomy, and 2 with isthmic salpingostomy. The pregnancy rates were 28%, 20%, and 0%, respectively. Within the terminal salpingostomy group, 5 of 18 patients treated with a prosthesis conceived, for a pregnancy rate of 28%. Nineteen of the 69 patients treated with an eversion technique conceived, for a pregnancy rate of 28%. No advantage with the use of a terminal prosthesis could be demonstrated. Tubal disease treated with techniques of salpingostomy was categorized according to a classification incorporating the several prognostic factors thought to influence subsequent conception. The pregnancy rate was found to be in direct relationship to the extent of tubal disease and pelvic adhesion formation. The tubal patency rate decreased in direct relationship to the extent of disease. The use of postoperative hydrotubation did not appear to improve the conception rate after salpingostomy for distal fimbrial obstruction.

ISSN:0029-7844    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

This report documents the second case of an ovarian pregnancy with a Cu-7 intrauterine contraceptive device. All of Spiegelberg's criteria were satisfied. A summary of the literature is presented, revealing 33 ovarian pregnancies in users of an IUD. The overall frequency of primary ovarian pregnancy is 1: 40,000 deliveries. There is a ratio of one ovarian pregnancy to nine ectopic pregnancies among IUD users, compared to 1:150 to 1:200 in the general population.

ISSN:0029-7844    

出版商:OVID    

年代:1978

数据来源: OVID