摘要:

The mean peripheral artcriovenous difference for dehydroepiandrosterone (DMEA), dehydroepiandroslerone sulfate (DHEA-S), androstenedione (A), Iestosterone (T), 5α dihydrotcstostcronc (DHT), and l7-hydro\yprogcsterone (17- P) has been calculated in 7 nonhirsule and 9 hirsule women. No significant difference was found between peripheral artery and vein concentrations for all steroids measured in both groups of women studied. Since steroid concentrations in peripheral arterial samples arc not expected to differ from those from ovarian and adrenal arteries, it is concluded that peripheral venous steroid levels adequately represent the steroid concentrations of arterial blood delivered to steroid-producing tissue.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Previous reports have demonstrated a significant incidence of pelvic symptomatology involving ovaries preserved following hysterectomy, to be called “the residual ovary syndrome” This report, in an 1 1-year retrospective analysis of all oophorectomies at The Methodist Hospital in Houston, Texas, identified 202 cases in which a previous hysterectomy had been performed. The majority of these patients presented with varying degrees of chronic pelvic pain (77.2%), asymptomatic pelvic mass (14.4%), and dyspareunia (67.0%). The incidence of malignant neoplastic change in these patients was 3.0%, related to whether hysterectomy was performed before or after the age of 40. In view of the incidence of the residual ovary syndrome and the risk of malignant neoplastic change when hysterectomy is performed after the age of 40, serious consideration of total ovarian ablation at the time of hysterectomy should be weighed against any temporary physiologic and/or psychologic benefits to be gained from conservation.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Plasma progesterone, estrone, and estradiol concentrations were determined in peripheral and ovarian vein samples in 9 women 20 to 30 minutes after delivery of the placenta during cesarean section. Progesterone concentrations in the ovarian vein draining the corpus luteum were significantly higher than the contralateral side or the peripheral concentration, confirming the activity of the puerperal corpus luteum. Estrone concentrations showed no significant difference between peripheral and ovarian vein samples, indicating little or no ovarian estrone secretion. The estradiol concentrations of the ovarian vein samples were significantly higher than peripheral levels. This indicates ovarian secretion of estradiol in the puerperium by areas other than the corpus luteum.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

A prospective study was undertaken to investigate the carbohydrate and lipid metabolic effects of the oral contraceptive nurethindrone. An oral glucose tolerance test was performed before and 1 year after the daily oral administration of 0.35 mg of norethindrome to 31 women. Measurements were made of glucose, insulin, cholesterol, and triglycerides. During the year there was no significant weight change in the women, and the fasting cholesterol values were unaffected by the steroid. The fasting triglycerides decreased as normally occurs in the late postpartum period. There was no change in the blood glucose curve, hut there was a statistically significant elevation produced in all of the plasma insulin values. These data suggest that this 19-nor progestogen steroid can affect the peripheral activity of insulin and thus require higher blood levels in order to obtain the same glucose homeostasis.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Unesterified arachidonic acid is the obligatory precursor of the prostaglandins (PG), PG2aand PGE2. In order to ascertain whether or not the human fetal membranes could represent a storage site for prostaglandin(s) precursor, the fatty acid content of human fetal membranes was measured. Approximately 20% cf the fatty acids found in fetal membranes obtained from nearterm, non-laboring women was arachidonic acid, whereas only 0.4% of the fatty acids of the parietal peritoneum of the mother is arachidonic acid. A small but significant decrease in the arachidonic acid concentration was found in the fetal membranes obtained from laboring women compared to that found prior to labor. On the other hand, the concentration of palmitic acid was increased in membranes obtained during labor while no significant changes in concentration in the remaining fatty acids were observed in membranes from laboring compared to non-laboring near-term gravidas. The significance of these observations in relation to the availability of prostaglandin precursor and the initiation of human parturition is considered.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Obstetric problems associated with 60 anencephalic births are analyzed according to cause and severity. Treatment of selected problems is discussed. Early diagnosis and the real problem—prevention—is stressed.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Rupture of the uterus is still a very common obstetric emergency in developing countries, and the urinary bladder is often injured in these patients. This fact is not fully documented in the literature. One hundred consecutive cases of rupture of the uterus in patients admitted during a 10-year period to the King George Hospital, Visakhapatnam, India, were analyzed. Bladder injury occurred in 22%. Thus, uterine rupture constitutes one of the important causes of bladder injury. In uterine rupture cases the most common clinical signs of concomitant bladder damage arc hematuria and meconium-stained urine. Instillation of methylene blue solution into the bladder during surgery can help to identify small bladder rents. Routine postoperative drainage of the bladder by indwelling catheter in all cases of ruptured uterus with suspected bladder injury is an important aid to healing of the contused, devitalized bladder and can avert vesicovaginal fistula formation.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

The simultaneous determination of estradiol, estrone, progesterone, and prostaglandins E and F has been made in fatal and maternal compartments in patients with and without the onset of labor. The decidua rather than the fetus or placenta was considered to be the site of prostaglandin synthesis, and prostaglandins present in the amniotic fluid during labor were thought to be a byproduct of myometrial activity rather than the factor initiating the onset of labor. Progesterone levels in the maternal plasma were lower during labor but estradiol levels were elevated. It was concluded that the steroid environment may contribute to the clinical course of labor by facilitating the local uterine production of prostaglandins. Whereas estradiol was high and estrone low in maternal circulation, the ratio was reversed in the fetus. This reversal may serve to protect the fetus from high maternal levels of estradiol.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

The pressor dose of infused angiotensin II was determined before and after rapid volume expansion with 800 to 1075 ml of highhetnatocrit blood There was no remarkable change in sensitivity to infused angiotensin demonstrated except in two in stance in which transient volume overload developed. The data support the hypothesis that increased angiotensin sensitivity observed in patients with pregnancy-induced hypertension is the consequence of increased vascular responsivity.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Amniotic fluid volume, Iecithin/sphingomyelin ratio, local phospholipid concentration and total phospholipid per sac were investigated in 53 term pregnancies. A definite influence of amniotic fluid volume on the phospholipid concentration was noted, while no influence on the L/S ratio was observed. Amniotic fluid volume showed a tendency to decrease after the 40th week of gestation. The total quantity of phospholipids per sac showed no significant variation between the 36th and 42nd week of gestation.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID