摘要:

The amount of total lipids of the amniotic fluid of normal human subjects increases progressively with gestational age and is found to be maximum in labor at term. The Iecitbin/sphingomyelin ratio, which invariably increases with gestational age, is 2:1 or greater beyond 34 weeks of pregnancy and becomes maximum at term labor. No definite correlation exists between the palmitic acid content of total lipids and gestational age; but the palmitic acid content of the lecithin fraction increases with gestational age and this increase is markedly accelerated near the 34th week of pregnancy. Also it is observed that the arachidonic acid of cholesterol esters increases with gestational age. Therefore, it is suggested that both the palmitic acid level of lecithin and the arachidonic acid level of cholesterol esters might serve as more reliable indices than current methods being employed for the assessment of fetal lung maturity.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

The contraction stress test (CST) was used to attempt determination of fetal reserve prior to labor by evaluating the response of the fetal heart rate to spontaneous or induced uterine contractions. Testing was performed by using an external fetal heart rate monitor and tocograph. The CST was employed 189 times in 120 high-risk patients who either had hypertensive disorder of pregnancy or had completed at least 42 weeks of gestation. Testing was begun as early as 34 weeks' gestation and repeated at weekly intervals; it was not used in the clinical management of the patient. The maximum number of tests performed on one patient was 8. A negative CST appears to be a most reliable guide to the ability of the fetus to tolerate labor if it ensues within 1 week. A positive test suggests that the fetus is at increased risk, but death is not necessarily imminent. Results of the present study warrant use of the CST in controlled studies to determine its effect in improving perinatal outcome.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

A retrospective study of congenital malformations in the offspring of 20 women who received antiepileptic drugs during pregnancy is presented. Of 56 births, 9 children (16%) were horn with malformations. Four children were born dead or died shortly after delivery. Congenital heart disease, cleft lip with or without cleft palate, neural unbe defects, and skeletal abnormalities were the commonest anomalies found. One child had a recognizable pattern of multiple malformations. The increased peritiatal mortality was mainly due to congenital malformations and spontaneous hemorrhage. The teratogenic activity of anticonvulsant drugs is mediated by interference with folic acid' metabolism, and such activity might be influenced by hereditary and environmental factors. Hearing in mind the importance of anticonvulsant therapy in epilepsy, there is certainly need for an investigation of the problem in a larger and more representative birth population than that described.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Human ovarian responses to FSH- and LH-releasing hormone (FSH/LH-RH) were observed at laparotomy and studied by histologic and histochemical examination of ovarian biopsy specimens. The responses were compared to those induced by human menopausal gonadotropin (HMG) and human chorionic gonadotropin (HCG) singly and together. The subjects were healthy, fertile, young women rendered anovulatory by injections of depome-droxyprogesterone acetate (DM PA) or depochlormadinone acetate (CA). Supplementary studies included measurement of urinary pregnanediol, examination of the cervix and vagina for estrogenic and progestational responses, and endometrial biopsy. Both HMG and HCG induced follicular growth and proliferation of granulosa and theca cells, but neither, when given alone, induced ovulation or corpus luteum formation. When given in conjunction they induced single or multiple ovulations and corpora lutea in 11 of 18 women treated. FSH/LH-RH consistently stimulated follicular development and induced ovulation in 2 of 1G women treated. Preovulatory mature follicles were found in 3 more. FSH/LH-RH may prove to be useful in the treatment of some cases of anovulatory sterility of hypothalamic origin

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Seven oophorectomized patients were administered a total of 60,00 units of human chorionic gonadotropin over a 3-day period, and plasma testosterone levels were obtained. One of the 7 patients demonstrated a definitive response to the hormone hut repeat testing proved to he negative. The potential role of luteinizing hormone in the pathogenesis of polycystic ovarian syndrome is discussed and current evidence linking LH to adrenal androgenesis is reviewed. Modifications that may he employed for future study arc suggested.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

A study or the incidence of X chromosome loss from the mitotic complement of human ovary has demonstrated a small loss beginning between ages 36 and -15 years and increasing additively to age 75. This was earlier and less than has been shown for blood. In ovarian tissue, autosomal chromosomal loss declined with age while X loss increased. Though no correlation of X loss could be demonstrated with the clinical state of the menstrual cycle, there was a greater loss of all chromosomes in normally cycling subjects than in perimenopausal and postmenopausal subjects. The possibility that the menopause is initiated in the ovary is raised by findings of these correlates of aging.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

To induce pneumnoperitoneum for laparoscopic examination, a transvaginal route and a modified Verres needle were used in an effort to reduce the failure rate of the subumbilical route and to avoid some of its dangers. The technic not only reduces the rate of complications, but its precision and simplicity make it easier to learn and execute.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

A gravid patient presented with gross hematuria in the last trimester of pregnancy but did not permit diagnostic measures. After delivery a large abdominal mass, which proved to be renal cell carcinoma, was found. Previously reported cases are reviewed, and the importance of adequate workup of hematuria during pregnancy is emphasized.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Because of lack of information in the gynecologic literature on the subject of hydrocele of the canal of Nuck, 5 cases arc reported here. The condition is reviewed, and the pathogenesis, clinical features, differential diagnosis, and management are discussed.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Intravascular hemolysis occurred twice in a series of 1582 consecutive intraamniotic midtrimester saline abortions. The hemolysis was associated with consumption coagulopathy and acute renal failure. Both patients made a complete recovery after a prolonged hospital stay; one required peritoneal dialysis. The pathogenesis of this serious complication of saline abortion is discussed hut no satisfactory explanation has been reached.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID