摘要:

Eleven normal female volunteers received human chorionic gonadotropin (HCG) intramuscularly to induce a pseudopregnant state. Twenty-five milligrams of prostaglandin F20(PGF20) was administered intravenously at selected times during the luteal phase to demonstrate a luteolytic effect, or a local effect upon the endometrium producing early vaginal bleeding. Careful comparison of hormone levels and clinical details in these cycles showed that a) 1000 IU HCG daily does not consistently prolong the luteal phase; b) 2500 IU HCG daily does significantly prolong the luteal phase;c) HCG administration significantly increases progesterone and estradiol output in the treated luteal phase;d) prostaglandin administration at selected times during the luteal phase does not consistently decrease estradiol or progesterone output from the corpus luteum or induce early vaginal bleeding;e) prostaglandin F20, a known stimulant of uterine contractility, probably causes vaginal bleeding by mechanical means, as evidenced by show of menses in patients with progesterone levels elevated above normal;f) although variations in progesterone and estradiol output occurred during the hours of prostaglandin infusion, no consistent change was observed except for a compensatory rebound in progesterone output;g) prostaglandin F20, in the dose utilized, is not a luteolytic agent.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

It has been demonstrated that in selected cases of subfertility in men, the first portion of the split ejaculate is superior to the specimen considered as a whole with regard to sperm density, sperm motility, and sperm morphology and also in those cases where there is increased seminal viscosity in the whole ejaculate. The use of a new coital technic, in which the husband practices coital withdrawal after the deposition of the better first portion of the ejaculate during the fertile time of the wife's cycle, has resulted in rapidly achiving pregnancy in many instances where the marriages had been barren for years. A documentation of 33 instances of pregnancy ascribed to this coital technic in the past 4 years, with detailed analyses of whole and split ejaculate semen, is presented.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

A prospective bacteriologic study on 67 women undergoing either vaginal or abdominal hysterectomy was done to elucidate causes of febrile morbidity. Forty-one percent of the vaginal and 35% of the abdominal hysterectomy patients met the criteria for febrile morbidity postoperatively. Preoperative and 24-hour postoperative urien samples were obtained by transvaginal bladder tap, and the freshly cut edge of the vaginal cuff was routinely swabbed following removal of the uterus. In addition, the subcutaneous layer was cultured during closure of the abdominal wound.Escherichia coli, Enterococcus, and α- and β-Streptococcuswere the predominant organisms recovered. The importance of routine vaginal cuff cultures at the time of surgery of the treatment of postoperative morbidity is discussed.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Endometrial biopsies were performed in asymptomatic IUD wearers on specific days of the menstrual cycle, and the histologic features were compared to those expected for the day of the cycle. Normal women who had endometrial biopsies performed as part of a sterility workup were used as controls. Endometrial asynchronism (defined as histologic delay or advance of 3 days or more) was observed in 33.5% of 113 biopsies performed on 79 women with IUD's; 30% showed a delay in endometrial development during the secretory phase. Our findings give further support to those who claim that contraception with the IUD is not achieved through one single process but that a number of mechanisms are possible. Endometrial asynchronism may constitute one of such modes of action.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

A series of 10 instances of genital actinomycosis infection complicating the use of intrauterine contraceptive devices is recorded and its pathogenesis described. The likelihood is suggested that this complication is more frequent than is generally appreciated. A pathway of infection extending upward from the patient's anus, across the perineum, and up the vagina and cervix is suggested as the route of infection. The traumatizing effect of the device and a previously existing or intercurrent infection as additional contributing factors to the development of actinomycotic infection in the female genitalia is also postulated.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Clinicopathologic findings in 8 patients with Paget's disease of the vulva are presented with a discussion of its pathogenesis. In 7 cases the disease was intraepithelial, and in 1 it was accompanied by underlying adenocarcinoma. The treatment of choice is surgical. The importance of early diagnosis, adequate excision, and close followup is emphasized. In 2 cases, the disease was associated with carcinoma of the breast and in 1 case with carcinoma of the liver.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

A greater than expected incidence of adenocarcinoma of the uterine cervix is reported. Among 41 cases of cervical carcinoma, 14 (34%) were adenocarcinoma. Clinicopathologic data for these cases are summarized. Eleven of the 14 cases were pure adenocarcinomas; 3 were mixed adenosquamous carcinoma. The value of cytopathology is demonstrated in the 7 of 9 pretreatment cervical cytologies whereby adenocarcinoma was indicated (an accuracy rate of 78%). The other 2 revealed abnormal cells in whic malignancy was a possibility. Three cases clinically were initially considered endometrial adenocarcinoma, but by our classification criteria, including Alcian blue staining for cervical mucin content of acid mucopolysaccharide, they were more specifically identified as primary endocervical in origin.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Fiftyeight cases of leiomyosarcoma of the uterus and 47 endometrial satcomas on the uterus are reviewed based on the pertiment information related to recurrence patterns. The following conclusions are made: 1) Cases of endometrial sarcoma should receive preoperative pelvic in radation, or postoperative pelvic irradiation if a diagnosis is not made until the postoperative period. This plan will probably be of most benefit, if at all in sage I disease 2) A case for pelvic irradiation as an adjuvant to surgery in leiomyosarcoma caunot be made from a review of this material either froma viewpoint of recurrence patterns or radio-responsiveness.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

There were 233 dermoid tumors of the ovary studied. Torsiom of the pedicle with hemorrhagic infarction proved to be the most frequent complication; malignant change was the most lethal. Nine patients with malignant dermoid tumors, most of them with locally advanced disease,w ere treated with conservative surgery, radiation and/or themotherapy. The logest known survivor lived 3 years most patients died with a year. It was concluded that a more aggressive surgical approach might salvage some patients with locally advanced malignant disease.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID