摘要:

Abdominal surgery (unrelated lu delivery) during pregnancy is not common. Review of a recent 17-year experience at our institution revealed 112 surgical procedures among 25.189 deliveries—an incidence of 0.44% (1 case for every 225 deliveries). Progestational agents have been used privphyiactically in such procedures, but few studies have adequately assessed the effectiveness of these drugs to prevent onset of premature labor. The present study involved 35 gravid patients who had been treated with various doses of hydroxy progesterone caproate before and after operations unrelated to delivery. These 35 patients were matched with 35 gravid control patients who had undergone similar operations but who had not received progestational compounds. Analysis revealed no significant difference in the abortion rate between these two groups.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

During the 17 years 1955 through 1971, 20 gravid patients underwent cholecystectomy. This represented 1 case for every 1259 deliveries (0.079% of 25.189 deliveries). The primary indication for surgery was repeated attacks of gallbladder colic. Generally, surgery was performed between the 10th and the 20th week of gestation. There was one spontaneous abortion; this occurred at 10 weeks of gestation, 42 days after surgery.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Eight hMG-hCG therapy cycles in 6 anovulatory infertile patients are presented. Daily plasma estrogen monitoring during the therapy contributed to success in inducing ovulation in all 6, 3 of whom established pregnancies and delivered healthy babies. The duration of hNIG therapy required varies among individuals. Duration and dosage can be determined on the basis of daily plasma estrogen levels. Administration of hCG is recommended to trigger ovulation when these levels reach 300 to 600 pg/ml. Although success in ovulation induction and pregnancy is achievable, multiple ovulation and multiple pregnancy cannot be predicted or prevented.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Previous investigators have demonstrated that 2.5 mg of progesterone, administered intramuscularly to rabbits on the day of ovulation and the 2 preceding days (Days −2, −1, and 0) significantly and consistently accelerates ovum transport. In contrast, when given on the day of ovulation and the 2 following days (Days 0, +1, and +2), progesterone does not accelerate ovum transport. The experiments reported were designed to define more precisely the temporal relationships critical to progesterone-induced acceleration of tubal ovum transport. Our observations suggest 3 important conclusions: 1) Progesterone, when given at least 1 day, and not more than 2 days, prior to ovulation does induce accelerated ovum transport. 2) The progesterone responsive mechanism is dose dependent. 3) The acceleration is partially antagonized if progesterone treatment is begun 3 days prior to ovulation.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Inappropriate milk-like secretion from the breasts is not infrequently encountered in patients. Usually these secretions have been identified as milk on the basis of their characteristic appearance, and only rarely has their identity as milk been proven by appropriate analysis. Since milk is chemically defined as a lactose-containing mammary secretion, the presence of lactose in a breast secretion identifies it as milk irrespective of its appearance or the presence of other constituents. Lactose can he readily identified by thin-layer chromatographic methods, which despite their inherent speed and sensitivity have not been widely utilized. A method using commercially prepared cellulose layers and a sandwich developing apparatus is presented in detail. This method utilizes current advances in chromatographic techniques and permits rapid and accurate identification of lactose in breast secretions. Such secretions from 10 nonpuerperal women were screened for the presence of lactose. The milk-like secretions from 8 contained varying amounts of lactose, which was not detectable in the secretions from the other 2. There was no correlation between the appearance of the secretion and the presence of lactose.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

In a continuing oral contraceptite study ofd-norgestrd, the 1.11mg dose—the dose presiouslr found to give the best cycle control—was administered cyclically on a “21–7 dat” schedule to 284 women during 2650 cycles. None of the women conceited, and cycle control, though often altered, was generally acceptable. Side effects were minimal, and laboratoy determinations performed prior to and during the administration of this agent revealed no clinically significant changes.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Plasma gonadutropin levels throughout the regular menstrual cycle in 10 Japanese women were measured daily using radioimmunoassay. At the peak of ovulation, mean FSII levels were 17.6 ± 7.9 mlU/ml and mean LH levels were 75.2 ± 26.0 mlU/ml. At midcycle, the mean gonadotropin levels were significantly loner in Japanese nomen than in Nigerian women who, as reported by Nylander (1973), had a high frequency of thinning. It is, therefore, suggested that the low frequency of ditygotic thinning in Japanese women might be related to their low output of gonadotropin.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Twelve women with congenital adrenal hyperplasia are reported. Initial diagnoses were made at ages ranging from 12 to 32, with epiphyseal fusion complete in all patients. During 6 to 10 years of corticosteroid therapy there occurred substantial reduction of hypertrichosis, disappearance of temporal recession, and decrease in eroticism. In 11 patients menstrual bleeding occurred within 4 months. Urinary excretion of total gonadotropins remained unchanged; total estrogens decreased slightly. By the end of followup, 7 patients with a mean age of 17 years had regular menses, 6 were ovulating, and I had a pregnancy. The other 5 patients, who continued to have irregular, anovulatory menstrual cycles, had a mean age of 28 years. The findings suggest that when excessive androgenization continues for a considerable period of time after puberty (as judged by bone age) noncyclic functioning of the gonadotropic mechanism is rendered irreversible.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Six cases of congenital vaginal atresia are described. Three of these patients had cryptomenorrhea while the other 3 had severe coital difficulties. Despite the fact that normal coitus was impossible in these 3 women, 2 of them achieved successful pregnancies and had to be delivered by emergency cesarean section followed by resection of the occluding membranes. The third patient (with dyspareunia) resorted to paraurethral coitus for more than 2 years before seeking advice. The management of vaginal atresia proved difficult because of the recurrence of stenosis at the site of the excised membrane. This was particularly marked in the young adolescent females not exposed to regular coitus. An operative method that could minimize this complication is discussed.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

In a patient with congenital absence of the uterus, daily measurements of progesterone (P), 17-hydroxyprogesterone (17-P), pregnenolone (Δ5P), 17-hcdroxypregnenolone (17-Δ5P), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), testosterone (T), dihydrotestosterone (DHT), androstenedione (A), estrone (E1), estradiol-17β (E2), and cortisol (F) were performed over a period of 48 consecutive days. Serum P, 17-P, and E2determinations revealed normal, cyclical ovarian activity consisting of two luteal phases and one follicular phase. Serum E1, Δ5P, and DHEA-S levels were normal throughout the study, whereas DHEA and DHT levels were persistently elevated. Serum levels of 17-.Δ5P and A showed peak levels above normal. Serum T and F concentrations were normal during the initial part of the study, but some elevation was seen during the second luteal phase. In the patient studied, absence of the uterus did not seem to interfere with cyclic ovarian activity. The role of the uterus in the metabolism of androgens remains subject to further investigation.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID