摘要:

Relaxin is a peptide hormone produced solely by the corpus luteum of pregnant women. Extracts of human pregnancy corpora lutea have relaxin activity in bioassay systems. This activity can be measured in a heterologous porcine radioimmunoassay (RIA). Immunoreactive relaxin was undetectable in the RIA in 51 nonpregnant women. In conception cycles, relaxin immunoactivity is detectable in peripheral blood by the time of the missed menses. Relaxin detection may be used as a pregnancy test. Relaxin may be an important luteal factor, together with progesterone, in early pregnancy maintenance.

ISSN:0029-7844    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

Eight patients suffering ruptured cerebral aneurysms during pregnancy were managed at the University of Western Ontario hospitals between 1967 and 1977. Seven aneurysms were managed surgically. AH of these patients survived, 1 with permanent neurologic deficit. Seven living infants were delivered, 6 by vaginal delivery and 1 by cesarean section. One pregnancy was terminated surgically. One maternal death occurred in a patient whose aneurysm was inoperable. Fetal heart rates (FHR) were monitored by Doptone monitor during the aneurysm surgery. Clipping of the aneurysms was performed under induced hypotension. The prognosis for ruptured cerebral aneurysms during pregnancy is good for both mother and fetus. A short course of conservative therapy followed by surgical management of the aneurysm is advocated. Delivery may be managed according to obstetrical indications following surgical correction of the aneurysm.

ISSN:0029-7844    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

Over a 20-year period at WHMC the annual incidence of acute antepartum pyelonephritis decreased from 4.0% to 0.8%. This decrease is correlated with the eradication of asymptomatic bacteriuria. Since urinary tract infections frequently recur, these antepartum patients must be monitored after therapy.

ISSN:0029-7844    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

Serum concentrations of total and ionic calcium, magnesium, phosphorus, and albumin were measured in maternal and cord blood of 115 near-term deliveries. The same measurements (except for ionic calcium) were made in blood obtained from corresponding newborns at 24 hours of age. Cord levels of all components exceeded maternal values, and maternal and cord levels correlated significantly with each other. In the case of calcium, the cord-maternal difference involved both ionic and protein-bound forms. Significant umbilical arterio-venous differences were found only in the case of total calcium, and this difference reflected variation in the protein-bound form only. During the first 24 hours postpartum, total calcium concentration fell (by an average of 0.75 mEq/liter), phosphorus levels rose (by an average of 0.63 mg/dl), and magnesium and albumin did not change significantly. Cord levels of all agents correlated significantly with corresponding neonatal values. In view of the significant positive relationships demonstrated between maternal and cord levels and between cord and neonatal levels, these results substantiate the importance of the maternal scrum ionic calcium concentration in normal perinatal calcium homeostasis.

ISSN:0029-7844    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

One hundred seven infants born after midtrimester amniocentesis were examined. The frequency of fetal injury was 9%, and was directly related to the number of attempts at amniocentesis. All were minor cutaneous injuries except for 1 case of disruption of a patellar tendon. Suggestions are made regarding ways to reduce the incidence of fetal puncture.

ISSN:0029-7844    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

Studies have shown that, in patients with threatened premature labor, fenoterol and ritodrine are effective agents for delaying its onset. However, the side-effects of these drugs can be a problem. Among 133 patients studied, the intravenous administration of either agent caused marked tachycardia (but no changes in blood pressure) and a high incidence of palpitations, trembling, and nausea. During oral therapy, subjective symptoms were less frequent. The addition of the calcium antagonist, iproveratril, to the therapeutic regimen did not influence the effectiveness of the 2 agents or the incidence of their adverse side-effects.

ISSN:0029-7844    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

Sixty-six premature breech deliveries were studied retrospectively. Forty-eight patients were permitted a trial of labor, 47 of whom ultimately delivered vaginally. Eighteen patients underwent cesarean section as soon as possible after their arrival at the delivery suite. When Apgar scores, perinatal mortality rates, cord prolapse, and entrapment of the aftercoming head are considered, cesarean section is probably the safer course of management for the patient with a footling breech infant, especially when the infant weighs 1500 g or less. However, the data indicate that a trial of labor can be safely undertaken in the presence of a premature frank or complete breech presentation.

ISSN:0029-7844    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

Serial maternal urinary excretion of estriol and pregnanediol in 329 patients in their last trimester of pregnancy are presented and compared. Most pregnancies were clinically normal, although some had obstetric complications such as hypertension, preeclampsia, suspected intrauterine growth retardation, or gestation prolonged beyond 42 weeks. In 220 patients, both estriol and pregnanediol excretion were above the 10th percentile levels. The gestation at delivery varied between 32 weeks and 44 weeks. In this group, the incidence of fetal distress during labor was 5.5%, the incidence of fetal growth retardation was 5.9%, and the perinatal wastage was 0.9% (P<0.001). In 30 patients with normal estriol excretion, the pregnanediol excretion was below the 10th percentile, and there were no perinatal losses. Only 2 patients showed fetal distress in labor, and 2 infants were growth retarded. In 26 patients with normal pregnanediol but low estriol levels, 9 infants showed intrauterine fetal distress (35%) and 9 infants (35%) were growth retarded (P<0.001). There were 53 patients in whom both estriol and pregnanediol excretion was subnormal. Intrapartum fetal distress was present in 21 patients (40%), 13 infants showed evidence of intrauterine growth retardation (25%), and there were 4 perinatal deaths (7.6%) (P<0.001). In conclusion, the fetus is likely to be in jeopardy when both estriol and pregnanediol excretion are subnormal, and serial pregnanediol levels arc likely to be of assistance in assessing fetal well being when urinary estriol levels are low due to causes other than intrauterine growth retardation, such as treatment with steriods or ampicillin, or rarely, placental sulfatase deficiency.

ISSN:0029-7844    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

Amniotic fluid (AF) and arterial blood were obtained almost simultaneously from 59 healthy third-trimester pregnant women. Oxygen and carbon dioxide tensions (Po2Pco2), pH, bicarbonate (Bicarb), total carbon dioxide (TCO2), Iactate (L), and pyruvate (P) concentrations were measured. Only AF-Bicarb, AF-TCO2, AF-pH, and AF-P showed a statistically significant correlation, negative, with gestational age. AF-Po2, AF-pH, AF-Bicarb, and AF-TCO2, were lower, and AF-Pco2was higher than in maternal blood. Amniotic fluid lactate was about 6 times, and AF-P was 2 times higher than maternal blood levels. The latter, the low bicarbonate, and the high Pco2all contributed to the acidic pH of AF. Amniotic fluid pH was affected by fetal and maternal variables, notably maternal pH. There was no correlation between AF-Po2and Pao2(arterial oxygen tension), between AF-Pco2and Paco2(arterial carbon dioxide tension), or between AF-L and blood L AF-Po2, AF-Pco2, and AF-L may correlate better with the intrauterine fetal status than AF-pH. Normal values obtained in this study should be useful as a baseline to monitor changes in the intrauterine environment in abnormal pregnancies.

ISSN:0029-7844    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

Transrectal ultrasonography has proved useful in the evaluation of genitourinary disease. Experience with prostate scans has shown that such conditions as prostate carcinoma and benign prostatic hyperplasia can be diagnosed and assessed with a high degree of accuracy. In patients with carcinoma of the bladder this method is useful in determining the degree of tumor invasion within the bladder wall. Our experience with scans of the uterus is in its early stages. We have studied 30 patients with documented cervical carcinoma and are studying 1) the presence and extent of parametrial involvement, 2) the ability to distinguish benign from malignant lesions, and 3) the identification of bladder invasion.

ISSN:0029-7844    

出版商:OVID    

年代:1979

数据来源: OVID