摘要:

Of 87 patients who were treated at the author's institution for primary cancer of the vagina, 31 had undergone total hysterectomy for benign disease. In this group of 31 patients, vaginal bleeding was the most common presenting symptom, although there were eight patients who were entirely asymptomatic and were diagnosed on routine examination. The stage of cancer was more advanced in the symptomatic patients than in the asymptomatic patients. There were seven patients with stage 0 disease, and four of these were asymptomatic and diagnosed by routine Papanicolaou smear. Overall, Papanicolaou smears were positive in 12 of 19 patients tested, a sensitivity rate of 63%. The authors recommend that patients who have a hysterectomy for benign disease continue to have Papanicolaou smears taken from the vaginal vault at regular intervals.

ISSN:0029-7844    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

An immunoradiometric assay using a monoclonal antibody detects an antigenic determinant (CA125) that is present in more than 80% of epithelial ovarian cancers. CA125 levels are elevated in the sera of 16% of women in the first trimester of pregnancy and is found in very high concentration in amniotic fluid. In 988 nonpregnant patients with benign gynecologic disorders, CA125 was greater than 65 U/mL in 1% on a single determination and in 0.5% with two determinations. Given the low rate of positivity in benign gynecologic disease, the CA125 assay may deserve further evaluation for the early detection of ovarian carcinoma.

ISSN:0029-7844    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

After an intensive course of combination chemotherapy, 16 patients with minimal residual ovarian cancer that was documented at second-look laparotomy, had an indwelling Tenckhoff catheter placed and underwent multiple peritoneal saline lavages. Lymphocyte-enriched populations from the peritoneal cavity and peripheral blood were obtained by density gradient centrifugation and examined for cell-surface phenotype and a variety of immune functions, including natural killer cytotoxicity and antibody-dependent cellmediated cytotoxicity. Phenotypic characterization revealed that peritoneal lymphocytes consisted primarily of T cells and cells bearing receptors for the crystallizable fragment of immunoglobulin G (IgG) (crystallizable fragment-receptor), and contained a very low number of B cells. Peritoneal natural killer lymphocyte cytotoxicity and antibody-dependent cell-mediated cytotoxicity were very low in all but two patients. Incubation of peritoneal lymphocytes withCorynebacterium patvumand interferon in vitro did not result in augmented cytotoxicity against susceptible targets. Supernatants from cultured peritoneal cells of all patients markedly inhibited natural cytotoxic activity of normal donor blood lymphocytes. These results suggest that lymphocytes collected from the peritoneal cavity of patients with minimal residual ovarian cancer are deficient in natural and antibody-dependent cytotoxic effector function. This deficiency may influence the host's ability to control the spread and proliferation of tumor cells in the peritoneal cavity.

ISSN:0029-7844    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

From 1976 through 1982, 72 rectosigmoid colectomies were performed on patients treated at the gynecologic oncology service at UCLA. Thirty-five of these were performed to resect primary or recurrent ovarian cancer, and 37 were performed as part of an exenteration for recurrent cervical or vaginal carcinoma. In 24 of the patients with ovarian cancer and 11 of the patients undergoing exenteration, the rectosigmoid colon was primarily reanastomosed, using either a primary suture technique or the end-to-end anastomosis stapler. Intraoperative management included adequate mobilization of the colonic mesentery to eliminate tension on the anastomosis, and liberal use of pelvic drains. Eighteen of 24 (75%) patients with ovarian cancer who received a primary reanastomosis did not have a protecting colostomy, whereas all 11 patients who underwent exenteration had a protecting colostomy. There were no anastomotic leaks in any of these patients, although morbidity occurred in seven of 35 patients (20%). There were no operative mortalities. The end-to-end anastomosis stapler has facilitated lower resections with primary reanastomosis. Colostomy is not mandatory in patients who have not had prior pelvic radiation therapy, and in whom no pelvic infection exists. Rectosigmoid colectomy permitted optimal or curative tumor resection in the majority of these patients, and thus should be performed whenever necessary to accomplish this goal.

ISSN:0029-7844    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

Sixteen intrauterine pregnancies (8.6%) have been documented among 187 women who had undergone direct placement of American-made Bleier clips for sterilization. Of these, five pregnancies (10.2%) followed clip placement in 49 cesarean deliveries, nine pregnancies (8.2%) followed 110 infraumbilical postpartum procedures, and two pregnancies (7.1%) occurred in 28 interval minilaparotomy patients. Resterilization by tubal segment excision has been performed in five unsuccessful cases. In one case, the excised portions of tube with clips in place were studied by radiologic and histologic methods. Tubal patency may persist if the oviduct is trapped in the catch portion of the clip.

ISSN:0029-7844    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

A double-blind study was carried out to compare the effect of submucous paracervical blockade using 12 mL 0.25% bupivacaine (55 women) to the effect of intramuscular injection of 75 mg meperidine (62 women) during the first stage of labor. All 117 were normal primiparous pregnancies. Seventy-eight percent of the women in the paracervical blockade group achieved full or acceptable pain relief against 31% in the meperidine group (P< .01). Transient fetal bradycardia occurred in two cases in the paracervical blockade group and one in the meperidine group; all infants were born in good condition. Fetal distress, defined as an umbilical artery pH of 7.15 or less and/or a one-minute Apgar score of 7 or less was more frequent in the meperidine group (16 infants) than in the paracervical blockade group (six infants) (P< .05). Submucous paracervical blockade is superior to intramuscular meperidine as pain relief during labor. Furthermore, meperidine results in more infants with asphyxia as compared with paracervical blockade.

ISSN:0029-7844    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

A triplet pregnancy is described in which there was a second trimester abortion of one fetus at 16 weeks' gestation. A cervical cerclage was placed, and tocolysis was used. The other two triplets were delivered 131 days later (at 35 weeks' gestation) by cesarean section. Both infants survived. This case is unique in the literature.

ISSN:0029-7844    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

Digoxin has been successfully used to treat fetal supraventricular tachycardia. When therapy with digoxin fails, alternative therapies have met with equivocal success. In this report, successful fetal therapy with maternally administered digoxin and quinidine is presented in three consecutive patients with fetal supraventricular tachycardia. The arrhythmia was eliminated in each instance. Fetal ascites, present in two fetuses, was completely reversed. Intrapartum fetal distress was not observed. The rationale of this therapy and a review of pertinent literature are also presented.

ISSN:0029-7844    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

Ectopic pregnancy after a total hysterectomy represents an unusual event. A survey of the literature reveals 29 reported cases. This report presents an additional case of early extrauterine gestation after total vaginal hysterectomy. Sonographic correlation is demonstrated.

ISSN:0029-7844    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

A case of supernumerary ovary is presented. This rare gynecologic abnormality, which is usually diagnosed on laparotomy or autopsy, was noted on laparoscopy.

ISSN:0029-7844    

出版商:OVID    

年代:1984

数据来源: OVID