摘要:

Combination chemotherapy has dramatically improved the results of treatment for embryonal rhabdomyosarcoma of the vagina in children, but little attention has been directed toward vaginal sarcomas in adults. This report of 17 cases of primary sarcoma of the adult vagina includes ten leiomyosarcomas, four mixed mesodermal tumors, one undifferentiated sarcoma, one stromal sarcoma, and one neurofibrosarcoma. The leiomyosarcomas, mixed mesodermal tumors, and the stromal sarcoma were morphologically similar to their uterine counterparts. Thirty-five percent of the patients had received pelvic irradiation for carcinoma of the cervix. Three of four patients treated by pelvic exenteration are alive and disease free after 84 to 161 months of observation. All 13 patients who received other forms of primary therapy died of recurrence. The pelvis was the first site of recurrence in all treatment failures and the only site of failure in 50%.

ISSN:0029-7844    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Adenoid basal and adenoid cystic carcinomas of the cervix are uncommon and differ from each other in their histology, treatment, and prognosis. Whereas adenoid basal carcinoma is a slow-growing, locally invasive lesion amenable to simply hysterectomy, adenoid cystic carcinoma is an aggressive tumor associated with regional lymph node involvement and late pulmonary metastases. This study, based on the evaluation of nine cases of adenoid cystic and five cases of adenoid basal carcinoma of the cervix, reviews the literature and formulates a program for the management of these rare lesions.

ISSN:0029-7844    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

NB/70K is a glycoprotein extracted from human ovarian cancer tissue. It was measurable postoperatively in the plasma of 89% of 127 women with epithelial cancer of the ovary; 60% of these women had levels in excess of 11 kU/mL compared with 5% of control subjects. The level of NB/70K correlated with FIGO stage and amount of residual tumor, but not with pathology subtype or tumor differentiation. Elevated NB/70K plasma levels also were found in patients with benign gynecologic neoplasms and a variety of systemic carcinomas, and modest elevation was observed in association with hepatic and renal decompensation. The highest levels, found preoperatively in women with ovarian cancer, decreased after tumor resection. These preliminary data indicate that the NB/70K assay has high sensitivity in epithelial ovarian cancer, and plasma levels appear to correlate with tumor volume.

ISSN:0029-7844    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Preoperative abdominopelvic computed tomography results and operative findings were compared in 52 patients undergoing second-look laparotomy to confirm tumor status. Seventeen true-negative, 22 false-negative, and 13 true-positive scans were found. The sensitivity was 0.38, specificity was 1.0, and diagnostic accuracy was 0.58. Negative studies were associated with positive findings at laparotomy in 42% of all cases. Fourteen patients were identified who had computed tomography that would have enabled an attempt at the diagnosis of persistent cancer by computed tomography-directed needle aspiration or biopsy, thus avoiding laparotomy. Assuming 80% accuracy of needle aspiration, the cost of computed tomography in all 52 patients is considerably outweighed by the savings that could have been realized by eliminating the need for second-look surgery in these 11 women.

ISSN:0029-7844    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Clinicopathologic data are presented for 22 cases of malignant mixed mesodermal tumors of the ovary of both homologous and heterologous types. The results substantiate previous reports of low parity in the almost exclusively postmenopausal women with this tumor. Symptoms were the same as for ovarian malignancy in general. More than half the patients presented with stage III or IV disease, according to the International Federation of Gynecology and Obstetrics (FIGO) classification. Only four (19%) of 21 patients were alive at 18 months and had survived from three to more than 13 years. Their survival was associated strictly with stage I or II disease and with the purely homologous stromal pattern. Two tumors were contiguous with remnants of ovarian endometriosis. Differentiated malignant epithelium was most often of the serous/endome-trioid type, frequently with squamous zones, and was of the mucinous type in only one case. Whereas spindle cell stroma was present in many tumors of both stromal types, atypical cartilage was the predominant heterologous element.

ISSN:0029-7844    

出版商:OVID    

年代:1985

数据来源: OVID

ISSN:0029-7844    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

The role of transamniotic fetal infection in the presence of intact membranes has attracted widespread attention. The present study is a reexamination of the autopsy material from 145 cases of macerated stillbirth observed in the National Maternity Hospital from 1979 to 1982. The objective was to ascertain the incidence of congenital pneumonia. No more than five cases were discovered, and in only two of these was there convincing evidence that the membranes were intact. The amniotic fluid infection syndrome seemed to be of little importance in the causation of late intrauterine death.

ISSN:0029-7844    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Obstetricians pay much attention to the diet and environment of the pregnant woman in prenatal care, but perhaps the woman's work also may affect pregnancy outcome. All women work in the home in addition to any work performed outside the home. The former component needs careful assessment; to get from home to work may be itself a stressful experience. In the workplace, women may encounter specific hazards of radiation or chemicals. More widespread are the problems of fatigue and boredom, which need careful assessment in relation to the outcome of pregnancy. These factors should be measured more precisely, thus allowing the physician to advise pregnant women better about the safe duration of work. Currently, advice tends to be overly cautious, as physicians are uncertain of the data on which such standards are based.

ISSN:0029-7844    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Rates of complications associated with a second trimester genetic amniocentesis were studied in 918 patients, and complete infant follow-up was obtained. In 903 singleton pregnancies and 15 twin gestations, the procedure was performed under continuous sector scanning guidance through an attached needle guide. Eight fetal deaths in the 903 cases occurred at less than 28 weeks after amniocentesis (0.89%), none within two weeks after the procedure. Only one fluid was visibly blood contaminated. Comparisons are made with other series from the literature.

ISSN:0029-7844    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

The course of pregnancy in a woman with homozygous type Ha hypercholesterolemia is described. Despite prepartum cholesterol levels as high as 700 mg/dL, her cholesterol level increased further during gestation. Pathological examination of the placenta did not reveal insufficiency or vasculopathy.

ISSN:0029-7844    

出版商:OVID    

年代:1985

数据来源: OVID