摘要:

Cellular samples obtained by vaginal scrapings from 204 women exposed to diethylstilbestrol (DES)in uterowere evaluated and compared with samples collected from a like number of controls. Several different sampling methods were evaluated. Vaginal scrapings contained columnar cells existing alone or in combination with squamous metaplastic cells and less frequently were characterized only by metaplastic cells. None of the control samples contained columnar cells and only 1 of 200 control samples contained metaplastic cells. The cellular findings in the offspring of women exposed to DESin uterovaried in relation to age. Cellular abnormalities were demonstrated in 90.4% of women having scrapings of visible lesions and in 88.1% of women studied by 4-quadrant vaginal scrapings in the absence of clinical disease. Of 58 women with histopathologically proven adenosis, 57 (98.3%) had similar cellular abnormalities. Abnormalities were demonstrated in squamous epithelial cells of the vagina in 8 (3.9%) of the women exposed to DESin utero. and in 5 of these women there were similar changes in the uterine cervix. Only 2 (0.9%) of the women had cellular changes suggesting dysplasia of the vagina.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Over the past 10 years, it has been well established that Crohn's disease may involve any segment of the gastrointestinal tract from the mouth to the anus and may also cause destructive extraintestinal lesions. Extensive cutaneous ulceration has recently been recognized as one of the rare extraintestinal complications. A case of chronic vulsar ulceration due to Crohn's disease is reported. The clinical manifestations and management of such a lesion are discussed.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

A retrospective study has been carried out on 25 patients treated at the University of Michigan Medical Center for carcinoma in situ of the vagina. Intraepithelial carcinoma of the vagina occurred as a primary entity, following treatment for preinvasive and invasive carcinoma of the cervix, and following hysterectomy for benign disease of the uterus. These patients were treated with either radium implantation or some form of surgery. Five patients had recurrences. These 5 were all subsequently retreated and are alive and without evidence of further recurrent neoplasm. This series of carcinoma in situ of the vagina is compared to other reported series. Emphasis is directed toward the need for continued use of Papanicolaou smear cytology tests in posthystereclomy patients, regardless of the reason for hysterectomy.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Seven cases of invasive vulvar Paget's disease are presented. These are compared with 10 cases of intraepithelial vulva Paget's disease. On the basis of both clinical and histopathologi observations, the concept of intraepithelial vulvar Paget's dis ease is supported, and this entity is distinguished from the in vasive form. Therapy for the latter is discussed.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Indium-111 attached to bleomycin is useful in the scintigraphic localization of a variety of tumors. Since it does not normally accumulate in bowel and feces, it is superior to other radiopharmaceuticals, such as gallium-67-citrate, in the demonstration of abnormalities in the abdomen and pelvis. Twenty-eight patients with known carcinoma of the cervix were studied with whole body111In-bleomycin scans. Two “false-positive” scans were produced by local inflammation. Six “false-negative” scans were attributed to small tumors escaping scintigraphic detection. In the remaining 20 patients, scan findings correlated well with site and extent of the tumor as determined by other means.111In-bleomycin scintiscanning may prove to be a highly useful adjunct in the evaluation of patients with carcinoma of the cervix.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

A case of contact dermatitis from neutral red dye applied for treatment of herpes genitalia is presented. A review of the literature revealed 5 other patients with a similar reaction. We suggest that neutral red dye treatment for herpes should be used with caution in patients with an allergic history.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

A case is reported of the successful treatment of multifocal intraepithelial neoplasia of the vagina by topical application of a cytotoxic agent, 5-fluorouracil. These lesions followed prolonged immunosuppressive therapy after renal transplantation. Intraepithelial neoplasia Has present also in the cervix and was treated by conization.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

In a patient with severe aortocaval compression, simultaneous brachial and femoral blood pressure measurements demonstrated the need for a 30° left-down tilt to avoid significant obstruction of the vessels. When emergency cesarean section became aecessary, proper positioning of the patient was readily accomplished. Since tilting of a pregnant woman leads to a marked increase in her alveolar–arterial oxygen difference, administration of a high oxygen concentration in the anesthetic mixture was essential until delivery of the infants; this was achieved by the use of fluroxcne analgesia.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID