摘要:

Over the past 20 years, the University of Washington Department of Obstetrics and Gynecology has conducted twice-yearly faculty at community sites spread over three time zones in Washington, Alaska, Montana, and Idaho. These workshops consist of three separate parts: 1) a sesion to report on student clerkship performance and faculty ratings, 2) a session on curriculum and/or teaching, and 3) a session to update medical topics. Faxculty found the worshops useful for improving their clinical teaching, deeping in touch with the full-time faculty, and developing a sense of cohesiveness. The department fount the workshops useful in maintaining the teaching of consistent content and ensuring that all sites provide students with comparable experiences and evaluation.

ISSN:0029-7844    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

ObjectiveTo provide the obstetrician-gynecologist with the following: 1) basic concepts of telomere shortening and telomerase acitvation and their relation to cellular immortalization and cancer, 2) an overview of potential uses of telomerase activity in cancer diagnosis, assessment of prgnosis, and the development of new anticancer therapeutic approaches, and 3) a review of the literature on telomerase activity in gynecologic cancers.Data SourcesA computerized search for articles published in which telomerase or telomerases were included as a subject heading or a textword was performed using the Ovid Search Software (Ovid Technologies Inc., New York, NY). The search was conducted of the following databases of the National Library of Medicine and the National Cancer Institute: MEDLINE January 1966 to May 1997, HealthSTAR January 1975 to May 1997, AIDSline January 1980 to May 1997, and CancerLit January 1980 to May 1997. Additional sources were identified through cross-referencing.Methods of Study SelectionAll sources identified were reviewed with particular attention to human application, specifically in gynecologic cancers.Tabulation, Integration, and ResultsA total of 304 references was identified. Each reference was reviewed to determine the relevant contribution to the basic understanding of the role of telomerase in cellular immortalization and the development of cancer, potential uses of telomerase measurement in cancer, gynecologic applications, and potential use of telomerase inhibitors in cancer therapy.ConclusionTelomerase activity might be a valuable diagnostic and prognostic toll in gynecologic and other types of cancer, and telomerase inhibition might prove to be a significant therapeutic approach for some types of cancer. Better understanding of the relation between telomerase activation, tumor suppressor genes, and oncogenes might clarify several aspects of early tumorigenesis and result in development of novel approaches to early cancer detection and prevention.

ISSN:0029-7844    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

ObjectiveTo test the hypothesis that researchers in obstetrics and gynecology favor an observational type of study design.Data SourcesThe 12 regular issues ofObstetrics & Gynecologypublished during 1996 were analyzed.Method of Study SelectionAll articles in the journalObstetrics & Gynecologywere reviewed for the year 1996, except that separate issues covering case reports, case condensations, and reviews were excluded.Tabulation, Integratin, and ResultsStudies were classified as observational or experimenta. Observational studies were subclassified as either descriptive, case-control, or cohort. Experimental studies were subclassified as either randomized controlled trial (RCT) or uncontrolled trial. Other study designs were noted. Of the 316 studies published during 1996, 241 (76%) were observational, 43 (14%) experimental, and 32 (10%) other. There were 162 (51%) descriptive studies, 44 (14%) case-control studies, 35 (11%) cohort studies, 35 (11%0 RCTs, and eight (3%) uncontrolled trials.ConclusionResearchers who publish inObstetrics & Gynecologyfavor an observational study design. With evidence-based medicine growing in Popularity as a new standard or paradigm, the reliance on observational studies may have implications.

ISSN:0029-7844    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0029-7844    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0029-7844    

出版商:OVID    

年代:1997

数据来源: OVID