摘要:

Synthetic luteinizing hormone releasing hormone (LHRH), 100 µg, was administered intravenously to 29 normal individuals. In male subjects, both baseline and peak LH reponse values showed minimal variations between subjects. The FSH baseline and response were more variable. In normal females the FSH and LH baseline values and response to LHRH infusion showed greater variation than that seen in male subjects, and this variation correlated with the phase of the menstrual cycle. In perimenopausal women with elevated baseline gonadotropins, the absolute LH peak values were comparable to those seen during the periovulatory period of the menstrual cycle, while FSH baseline and peak values were unmistakably higher than those observed in the normally menstruating women. Three women under gonadotropic suppression by three different drugs were investigated; megestrol suppressed the LHRH response more effectively than either diethylstilbestrol or an oral contraceptive. The LHRH stimulation test reflects only the ability of the pituitary cell to release gonadotropins. In a normal individual, however, some justifiable assumptions can be made regarding the immediate past synthesis and release versus accumulation of pituitary LH.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Thirty-eight patients with primary amenorrhea were evaluated by the administration of luteinizing hormone releasing hormone (LHRH). The LHRH stimulation test was not helpful in differentiating those patients who will proceed to normal menses from those who will continue to have prolonged dysfunction. Similar responses were observed in patients with different pathology, which indicates that the LHRH test must be utilized in conjunction with a carefully planned evaluation if it is to he useful in differentiating a hypothalamic from a pituitary defect. The finding of a patient w*ith hypergonadotropism by serum radioimmunoassay and negative gonadotropins by bioassay suggests that the radioimmunoassay may detect a biologically inactive molecule and indicates that both assays are essential in the evaluation of primary amenorrhea.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Luteinizing hormone releasing hormone (LHRH), 100 µg, was administered to 60 patients with secondary amenorrhea. No side effects or adverse reactions occurred. Delayed FSH and LH peak outputs were observed in patients receiving LHRH subcutaeously rather than intravenously, but responses were otherwise comparable. The majority of patients with secondary amenorrhea had responses which fell into the 95% confidence limits of responses for normal ovulating women. Responses of patients with different forms of dysfunction may be similar, and patients with similar pathology may respond quite differently. The LHRH stimulation test may assist in the diagnosis of particular hypothalamic, pituitary, or gonadal dysfunction, but it must be used clinically in the context of a carefully integrated study.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

A new analog of luteinizing-hormone-releasing factor, [Des-Gly-NH210, Pro-ethylamide9]-LHRF, was tested in healthy women with regular menstrual cycles. This synthetic nonapeptide amide was injected intravenously in a dose of 200 µg into 15 normal female volunteers in the follicular, preovulatory, and luteal phases of the menstrual cycle, and the serum LH and FSH responses were compared with those to the same dose of the synthetic decapeptide LHRF in 15 controls. The new analog exhibited significantly higher activity than the synthetic decapeptide LHRF in the release of LH in the follicular (P<0.05), prcovulatory (P<0.01), and luteal phases (P<0.05). In contrast, no statistical significance in the magnitude of FSH response was demonstrated in any phase of the menstrual cycle. The serum LH and FSH response to the nonapeptide amide suggested a longer physiologic half-life of the new LHRF analog. The results are similar to a previous report in men with normal gonadal function, and a clinical usefulness for the new analog is expected.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Medroxyprogesterone acetate (MPA) was administered, as a contraceptive, by intramuscular injection in doses of 150 mg every 90 days, or 300—150 mg every 180 days, to 5 women, over a period of 27 to 42 months. No major adverse reactions were reported, and the minor side elfects were only as frequent as those reported for oral contraceptives. The LH basal levels were depressed in all subjects; FSH and prolactin serum concentrations were within the range found in normally cycling women. Synthetic TRH released prolactin in 4 subjects, and the maximal response was within 10–20 minutes after TRH injection. In the fifth case there was no prolactin release.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Previous studies from this laboratory have included reports on the serum concentrations of the following steroids in premenopausal and postmenopausal women: pregnenolone, 17-hydroxypregnenolone, progesterone, 17-hydroxyprogesterone, cortisol, corticosterone, dehydroepiandrosterone, dehydroepiandrosterone sulfate, androstenedione, testosterone, dihydrotestosterone, estrone, and estradiol 17-ß. In general the steroid levels were lower in postmenopausal subjects, and this difference was significant at P<0.05 for 8 of the steroids. The significantly decreased peripheral level of steroids in the postmenopausal state can he explained by decreases either in ovarian secretion of steroids or in ovarian stimulation of the adrenal cortex. Since the contribution of the adrenal cortex to the peripheral levels of dehydroepiandrosterone sulfate (DHEA-S) is greater than 95% in premenopausal women, a plausible explanation for the marked drop observed in peripheral DHEA-S levels after menopause is that the ovary influences the steroidogenic activity of the adrenal cortex. In such cases a decrease in the stimulation of the adrenal cortex by some ovarian steroids would he expected. Estrogen therapy in 10 postmenopausal women resulted in significant increases in the serum levels of 3 of the steroids compared to those in untreated subjects, confirming the postulate that ovarian estrogens stimulate the secretion of adrenal androgens.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Data on 100 consecutive patients delivering within 1 week after ultrasonic cephalometry measurement were reviewed to assess the weight-predicting potential of three known formulas. With Thompson's formula, 78% of infant weights fell within a range of 350 g, the absolute mean error for the 100 cases being 267 g. Excluding cases of fetal malnutrition, when the biparietal diameter (BPD) obtained was 8.3 cm or more, all newborn babies weighed more than 2000 g, and with a BPD of 8.7 cm or more they all exceeded 2500 g. Ninety percent of newborn babies in whom the in utero BPD was 9.1 cm or more weighed more than 3000 g. These values compared very favorably with those from other series and, thus, demonstrate the usefulness of this type of assessment.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Sonographic examinations were performed on 13 patients whose fetuses had the following congenital malformations: anencephaly (4 cases), hydrocephaly (4), obstruction of the renal excretory system (3), iniencephaly (1), and sacrococcygeal teratoma (1). In 7 cases the initial diagnosis was made by sonography, in 6 cases by radiography. Sonography was valuable a) in the detection of discrepant growth between fetal chest and head and b) in the recognition of fetal soft tissue abnormalities. It is concluded that sonography is a valuable aid in the diagnosis of congenital fetal anomalies.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Labor contractions in 20 patients in spontaneous labor and 40 others who received either PGF2αor oxytocin for stimulation of the active phase of labor were statistically analyzed during 1 hour of labor. Measurement criteria were the frequency, intensity, and duration of contractions. Statistical analysis failed to reveal any significant difference in contractions in the three groups, suggesting that oxytocin and PGF2α-induced contractions and spontaneous contractions appear to be indistinguishable.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Clinical experience with the latex and new estane balloons and a short and flexible guide is described. The extraovular balloon as an intrauterine pressure sensor is compared to the open-ended transcervical intraamniotic catheter, and the balloon is considered superior in many respects. The transcervical extraovular water-filled 0.8-ml estane balloon is recommended for use in place of the open-ended transcervical catheter in all clinical situations in obstetrics in which there is a need for monitoring intrauterine pressure.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID