摘要:

Plasma prostaglandins were studied by radioimmunoassay on alternate days during the menstrual cycle in fourteen normal women. No cyclic patterns were found for A-like prostaglandins using an assay which measured 13,14-dihydro-PGA. Mean subject values of PGA-like prostaglandin ranged from 367 to 904 pg/ml and varied significantly among women. Prostaglandin E determinations showed an upward trend beginning 8 days before the LH peak. PGE subject means varied significantly and ranged from 182 to 362 pg/ml. Prostaglandin F did not exhibit a cyclic pattern. The average concentration of PGF for individual women ranged from 58 to 153 pg/ml, showing significant variance. The physiologic implications of the results are discussed as well as recommendations for the design of future studies.

ISSN:0029-7844    

出版商:OVID    

年代:1977

数据来源: OVID

摘要:

During a 30-month period 229 couples were evaluated for infertility at the Naval Regional Medical Center, Oakland. Laparoscopy was used in all cases of otherwise unexplained infertility. The resulting laparoscopic examination of the female partner of 24 such couples demonstrated abnormal findings in 18 (75%). Of these 18 subjects, unsuspected endometriosis was found in 11 (46%) and peritubal adhesions in 7 (29%). Of the 229 couples evaluated, only 8 (3.5%) failed to show some etiologic factor associated with infertility. Thus, the previously reported 10 to 20% incidence of unexplained infertility is too high an estimate in view of the additional information made available through pelvic endoscopy.

ISSN:0029-7844    

出版商:OVID    

年代:1977

数据来源: OVID

摘要:

Experience is reported with 28 uterine perforations encountered from June 1,1973, to June 1,1976, among 20,000 first trimester abortion patients at Reproductive Health Services, St. Louis, Missouri. In order to prevent this complication, one must perform an exacting pelvic examination. The use of a sound is controversial. Dilators should be introduced only a short distance through the internal os, and as much of the products of conception as possible should be aspirated. A sharp curette should be used diagnostically. Various questions should be asked before the operator contructs a scheme for managing perforation. The current policy for management used at this clinic is outlined.

ISSN:0029-7844    

出版商:OVID    

年代:1977

数据来源: OVID

摘要:

Over a 21-year period, 213 women with mature teratoma of the ovary were operated on at Parkland Memorial Hospital. Twenty-seven had bilateral tumors. In 22 of these 27 patients, bilateral involvement was evident on clinical examination, and in 5, biopsy of an abnormal but nonteratoid appearing ovary was required to make the diagnosis. Ninety patients with a visually normal opposite ovary had no identifiable tumor in that ovary by investigative incision or incidental excision. Neither incision nor excision of the normal contralateral ovary was performed in 58 cases, and subsequently, one of these women is known to have developed a teratoma in that ovary. We conclude that synchronous covert bilaterality of mature teratomas is not common, and a visually normal contralateral ovary should not routinely be bivalved or wedge biopsied.

ISSN:0029-7844    

出版商:OVID    

年代:1977

数据来源: OVID

摘要:

Forty-one cases of primary fallopian tube carcinoma treated at our institution over the years 1946 to 1976 are described. The overall 5-year survival rate was 34.4%, although patients with early tumors had a 72.7% survival rate. The single most important factor affecting survival appeared to be the extent of disease at the time of diagnosis. Past and present treatment modalities arc discussed, and proposals for management of this disease are outlined.

ISSN:0029-7844    

出版商:OVID    

年代:1977

数据来源: OVID

摘要:

Seventy patients with cervical cancer who were not candidates for primary operative treatment underwent operative evaluation prior to radiation therapy. Thirty-one were explored through a transperitoneal approach and 39 through an extraperitoneal approach. The operative procedure consisted of bilateral pelvic and periaortic lymphadenectomy and exploratory laparotomy, with additional intraperitoneal biopsies taken as indicated by operative findings. Poor correlation was seen between operative findings, lymphangiography, and clinical staging. Radiation therapy was extended to include sites of biopsy proven metastases. The group of patients operated on through a transperitoneal approach experienced a 30% complication rate secondary to small bowel damage following radiation therapy, and 2 patients died as a result of complications. All patients with small bowel complications explored in this manner required surgical correction. The group of patients operated on through an extraperitoneal approach had a 2.5% morbidity secondary to small bowel complications, and there were no deaths or serious complications in these patients. No patients explored in this manner required subsequent operation for complications following radiation therapy.

ISSN:0029-7844    

出版商:OVID    

年代:1977

数据来源: OVID

摘要:

Between January 1950 and March 1965,382 patients with carcinoma of the uterine cervix were treated with parametrial radiogold injections. One hundred and ninety-two patients are known to have survived 5 or more years after the treatment without evidence of recurrence. Major complications with significant morbidity requiring hospitalization or additional surgery was observed in 9.4% of the patients. Parametrial radiogold injection is associated with a high incidence of major lower urinary tract complications, including an increased incidence of ureteral obstruction as a result of radiation fibrosis. Heterogenous distribution of radioactive material with localized areas of heavy irradiation is probably responsible for the development of late major complications.

ISSN:0029-7844    

出版商:OVID    

年代:1977

数据来源: OVID

摘要:

Necrotizing fasciitis is a rare but rapidly progressive soft tissue infection not previously reported in an obstetric patient. Since cure is dependent on rapid recognition and early surgical intervention, 4 cases are reported herein, the bacteriology discussed, and the literature reviewed.

ISSN:0029-7844    

出版商:OVID    

年代:1977

数据来源: OVID

摘要:

A carefully controlled comparative study showed miconazole nitrate 2% vaginal cream (Monistat) to be a highly effective agent in the treatment of vaginal candidiasis in pregnant subjects. Miconazole nitrate was significantly more effective than nystatin (Mycostatin) in the treatment of vaginal candidiasis in ail three trimesters of pregnancy, and also more effective regardless of whether the candidal infection was primary or recurrent. Observations relating to the safety of this therapy during pregnancy were made and discussed.

ISSN:0029-7844    

出版商:OVID    

年代:1977

数据来源: OVID

摘要:

The function of the corpus luteum at midtrimester and at term was studied in 19 pregnant women. Six women had their pregnancies terminated by hysterotomy at 14-18 weeks. The remaining 13 women were delivered by cesarean section at term. Luteectomies were also performed on 6 women at the time of cesarean section. Progesterone and relaxin levels in peripheral blood serum were used as indices of luteal activity. Relaxin is a product of the human pregnancy corpus luteum. Relaxin secretion correlates well with luteal progesterone secretion. After cesarean section at term the decline in serum progesterone was parallel to that observed after hysterotomy at midtrimester, although the absolute levels were much higher at term. On the other hand, the actual relaxin concentrations, as well as the decrease in relaxin levels seen after evacuation of the uterus, were similar at midtrimester and at term. After luteectomy there was a more precipitous decrease in serum levels of both progesterone and relaxin than seen in nonluteectomized patients. Thus, in contrast to previous findings in lower primates, the corpus luteum of human beings does not regress in midpregnancy but, instead, remains functional throughout pregnancy. There is continued secretion of luteal progesterone and relaxin in the puerperium. The corpus luteum appears to be the only source of these hormones in the puerperium.

ISSN:0029-7844    

出版商:OVID    

年代:1977

数据来源: OVID