摘要:

An evaluation of histologic factors in 115 patients with carcinoma of the uterine cervix, Stage I, treated by radical hysterectomy and extirpation of pelvic lymph nodes disclosed that patients 45 or younger did poorly; the frequency of lymph node metastases and the mortality were greater than in the older group; the difference was statistically significant. Stromal invasion of greater depth than 5 mm, lymph node metastases, and parametrial involvement were factors of ominous prognostic significance. Well differentiated carcinomas (Grade I) had the highest rate of lymph node metastases and generally did poorly. Undifferentiated carcinomas (Grade III) had a low incidence of lymph node metastases and did very well. It is suggested that radiotherapy should be the primary choice for Grade I cancers and surgical treatment for Grade III ones. Either mode of therapy appears equally successful with Grade II cancers. A dense lymphocytic infiltrate accompanying Grade II and III cancers appears to have a favorable influence on the outcome of treatment.

ISSN:0029-7844    

出版商:OVID    

年代:1970

数据来源: OVID

摘要:

This report is a retrospective analysis of the course of 253 patients with cervical carcinoma treated by radiation therapy. The carcinomas were classified according to the histomorpho- Iogic criteria previously outlined by Reagan. Statistical analysis by the chi-square test showed a highly significant difference in survival of the large-cell nonkeratinizing carcinoma as compared to both the keratinizing and smallcell carcinomas at both 2- and 5-year periods. The survival of patients with keratinizing carcinoma as compared to those with small-cell carcinoma was found to be probably significant in one-half of the comparisons while the remainder were not significant.

ISSN:0029-7844    

出版商:OVID    

年代:1970

数据来源: OVID

摘要:

The problems accompanying radiation necrosis following treatment of cervical cancer are reviewed, and the results attained in 77 cervical cancer patients treated surgically are presented. Of the 77, 17 had conservative operations and 14 lived 5 or more years. Of 40 patients who underwent radical hysterectomy and pelvic node dissection, 31 lived 5 or more years. Of 20 patients subjected to pelvic exenteration for radiation necrosis, 7 lived 5 or more years. The results achieved in terms of lengthened survival appear to have justified the operations, since existence was anything but bearable in most instances.

ISSN:0029-7844    

出版商:OVID    

年代:1970

数据来源: OVID

摘要:

Certain brain gangliosides are highly specific inhibitors of rhesus antibodies in vitro and useful guides to the structural and electrochemical requirements for effective inhibition. This proposition was examined with the of molecular models and a hypothetical inhibitor structure proposed. A range of chemical substances bearing some relation to the hypothetical inhibitor was tested for activity vitro and it was found that para-amino-salicylic acid, which bears the nearest resemblance, weak inhibitor of the rhesus antigen-antibody reaction under these conditions. However, hydration is shown to be at least as important as structural and electrochemical factors mode of action of rhesus inhibitors.

ISSN:0029-7844    

出版商:OVID    

年代:1970

数据来源: OVID

摘要:

A total of 58 Rh-sensitized pregnancies with mid-zone spectral absorption peaks were studied to determine whether outcome could be prognosticated. Absolute levels were not clearly related to survival or severity of erythroblastosis fetalis, but relative trends were. Progressively rising peaks were associated with significantly higher perinatal mortality, more frequent and severe anemia, and greater need for exchange transfusions in the neonate. The more rapid the rise, the worse the outlook.

ISSN:0029-7844    

出版商:OVID    

年代:1970

数据来源: OVID

摘要:

In an effort to produce an experimental biologic model simulating human erythroblastosis and hydrops fetalis, fetal lambs were exsanguinated slowly or were treated with a hemolytic agent. Although fetal anemia did result, no hydrops was observed. When a protein inhibitor was added to the treatment, hydropic changes were produced more consistently even though there was no measurable decrease in the fetal plasma protein concentration.

ISSN:0029-7844    

出版商:OVID    

年代:1970

数据来源: OVID

摘要:

Oral contraceptive therapy produces an elevation of blood pressure in a few susceptible individuals. In an attempt to define a group of normotensive women in whom elevation of arterial pressure might be anticipated, 96 women with a prior history of toxemia of pregnancy were surveyed to determine the effects of oral contraceptive therapy on their blood pressure. No significant differences were found when the entire group was used for comparison. However, when 25 normotensive pilltakers were matched as nearly as possible by age, race, parity, arm circumference, and severity of toxemia with a group of normotensive nonpill-takers, both systolic and diastolic pressures were higher among the group receiving oral contraceptive medication; the diastolic difference was significant at the 0.05 confidence level. Patients with a blood pressure of no more than 140/90 were considered normotensive for the purpose of this survey.

ISSN:0029-7844    

出版商:OVID    

年代:1970

数据来源: OVID

摘要:

A comparative study of patients attending a county family planning clinic showed a doubling of the number of parous females under the age of 18. A significant decrease in the pregnancy rate among 19- to 25-yr-old women requesting contraceptive advice was noted. The continuation rates for oral contraceptives and intrauterine devices during a 28-month period of time was 80%. Consideration is given to the possibility of providing permanent contraception by sterilization to those patients who by reason of age or parity no longer desire future pregnancies.

ISSN:0029-7844    

出版商:OVID    

年代:1970

数据来源: OVID

摘要:

Colposcopically guided pre- and post-treatment cervical biopsies were made in 58 highly parous women, most of whom were more than 30 years of age, given an estrogen-progestogen contraceptive tablet for periods varying from 6 to 40 months. No precancerous changes were uncovered. The histopathologic alterations attributable to the use of the steroidal contraceptive agent were those of normal pregnancy. The cytologic and colposcopic findings were supportive of the histologic observations.

ISSN:0029-7844    

出版商:OVID    

年代:1970

数据来源: OVID

摘要:

Immunoreactive insulin was found in amniotic fluid among 32 gravidas when pregnancy had advanced beyond the 16th week and when the fetus was alive. The concentrations were equivalent to or higher than fasting serum levels present in normal nonpregnant adults. No insulin was measurable in 1 patient at 16 weeks' gestation, a small quantity was found in another at 20 weeks, and increased concentrations thereafter. In 3 women in whom the fetus was dead, no insulin was present. Recovery experiments showed that insulin in amniotic fluid can be measured accurately by radioimmunoassay, even in the presence of meconium. Some variable changes in amniotic fluid insulin concentrations appeared to occur in response to maternal glucose loading.

ISSN:0029-7844    

出版商:OVID    

年代:1970

数据来源: OVID