ISSN:0029-7844    

出版商:OVID    

年代:1982

数据来源: OVID

摘要:

Eighty-eight patients presenting with signs and symptoms that suggested ectopic pregnancy, all of whom had a positive radioreceptorassay (Biocept-G), were studied. Sixty-one patients (69% ) were found to have intrauterine pregnancy. Twelve (14% ) had unruptured tubal ectopic pregnancy with a mean (± SEM) human chorionic gonadotropin (hCG) level of 1190 ± 320 mlU/ml, whereas 15 (17% ) with ruptured ectopic pregnancies had a mean hCG level of 4160 ± 400 mlU/cml. Among these 2 types of ectopic pregnancy, the mean hCG levels were statistically different (t =5.0, P <.001). Possible reasons for these differences are suggested, and the clinical implications of this finding are discussed.

ISSN:0029-7844    

出版商:OVID    

年代:1982

数据来源: OVID

摘要:

Oral contraceptives reduce the elevated androgen levels in polycystic ovary disease. However, treatment with oral contraceptives is associated with undesirable side effects because of their high estrogen content. This study was undertaken to examine the effects of low estrogen-containing oral contraceptive (Loestrin:norethindrone acetate 1.5 mg and ethinyl estradiol 30 μg) on 25 women with polycystic ovary disease of ovarian origin. Loestrin treatment normalized the elevated luteinizing hormone and total and unbound testosterone levels and increased testosterone binding globulin levels. In a time–course study, unbound testosterone declined within a week of initiating treatment and by 12 to 16 weeks was completely normal. Reduction in hair growth and improvement in complexion were noted by about 12 to 16 weeks. Side effects of treatment were minimal.

ISSN:0029-7844    

出版商:OVID    

年代:1982

数据来源: OVID

摘要:

The anaerobic and aerobic flora of the vagina was identified in 79 postmenopausal women, 33 of whom received estrogen replacement. Four anaerobic species were more prevalent among estrogen-treated women than among untreated women, whereas 2 anaerobic species were less prevalent in the treated group. The types of organisms isolated from both groups are similar and all organisms isolated were considered usual inhabitants of the genital tract.

ISSN:0029-7844    

出版商:OVID    

年代:1982

数据来源: OVID

摘要:

Ninety-one patients were enrolled in a prospective randomized double-blind study evaluating the efficacy of systemic antibiotic prophylaxis in reducing the incidence of operative site infection after abdominal hysterectomy. Forty-five patients received a 2-dose course of cefoxitin; 46 patients received a placebo. Although patients in the antibiotic group had a lower fever index, there were no statistically significant differences between groups with respect to incidence of pelvic cellulitis, urinary tract infection, wound infection, need for therapeutic antibiotics, or duration of hospitalization. It is concluded that, in this patient population, the theoretic risks of widespread use of systemic antibiotics for prophylaxis outweigh the observed benefits.

ISSN:0029-7844    

出版商:OVID    

年代:1982

数据来源: OVID

摘要:

Two hundred twenty-six consecutive women attending an inner-city clinic for sexually transmitted diseases were evaluated. Problem-directed histories and physical examinations were conducted and vaginal specimens for wet preparation and Trichomonas vaginalis culture were obtained from each patient. One hundred patients were found to be infected. Patients with multiple sex partners were found to be at increased risk of trichomoniasis (P<.05). Those with abnormal discharge noted on examination had a higher frequency of positive cultures for T vaginalis (P<.001). Only 50% of patients with trichomoniasis had an abnormal discharge. Patients with greater than 10 white blood cells per high power field on wet preparation, regardless of whether trichomonads were visualized, had a higher incidence of trichomoniasis (P<.01). Factors that were not associated with Trichomonas infection included patient age, frequency of coitus, date of most recent coitus, day of menstrual cycle on which patient was examined, recent antibiotic use, use of contraceptives or specific contraceptive methods, symptoms of discharge or pruritus, or the finding of Leptothrix on wet preparation. These data support the contention that the classic description of trichomoniasis cannot be uniformly relied upon for diagnosis, but that patients with multiple sex partners, abnormal vaginal discharge and/or greater than 10 white blood cells per high power field on wet preparation are at increased risk of infection by T vaginalis

ISSN:0029-7844    

出版商:OVID    

年代:1982

数据来源: OVID

摘要:

Daily vaginal douching with polyvinylpyrrolidone-iodine in 12 euthyroid volunteers for 14 days resulted in a significant increase in serum total iodine concentration and urine iodine excretion. The increase in serum total iodine was associated with a marked decrease in 24-hour iodine 123 uptake by the thyroid and a small but significant increase in serum thyrotropin (TSH) concentration. However, values for serum TSH never rose above the normal range. No significant changes in serum thyroxine (T4), free T4 index (FTI), or triiodothyronine concentrations were observed, although serum T4 and FTI did decrease slightly during treatment. The findings suggest that iodine is absorbed across the vaginal mucosa and that the subsequent increase in serum total iodine does induce subtle increases in serum TSH concentration. There was no evidence, however, of overt hypothyroidism in these euthyroid women.

ISSN:0029-7844    

出版商:OVID    

年代:1982

数据来源: OVID

摘要:

The 3-year screening interval recommended by the American Cancer Society would appear to decrease the detection of premalignant and malignant disease. The authors have shown that 20% of study patients in whom subsequently invasive cervical cancer developed had at least 2 negative Fapanicolaou smears within 3 years of the diagnosis of cancer. Moreover, the majority of false-negative results in the series could be attributed to sample error. The authors recommend yearly or at least biennial cervical cytologic screening.

ISSN:0029-7844    

出版商:OVID    

年代:1982

数据来源: OVID

摘要:

Cervical smears taken by the wooden Ayre spatula (widely used in the United Kingdom) and by a plastic spatula (Armovical) were compared for their ability to detect dysplastic cervical epithelium and endocervical cells. At the same time, the value of taking duplicate smears was assessed. Paired cervical smears were obtained at a single attendance from 21,352 women, using the 2 types of spatulas in 4 different sequences. Although individually the Armovical proved superior to the Ayre spatula for the collection of endocervical epithelial material, this advantage was not complemented by any marked improvement in its detection of cervical dysplasia. Paired smear sampling, however, was clearly more rewarding in this respect and also allowed the introduction of laboratory quality control, as each preparation of any given pair was examined by a different screener. The false-negative rate was 18.5% it comprised 11.1% sampling error and 7.4% screening error. It is concluded that paired smear sampling in population screening would significantly reduce the false-negative rate.

ISSN:0029-7844    

出版商:OVID    

年代:1982

数据来源: OVID

摘要:

Thirty-three patients with vulvar intraepithelial neoplasia were treated with the carbon dioxide (CO2) laser. In 31 of these patients the lesion was completely eradicated by the laser treatment. All patients experienced moderate pain following the procedure, and 2 had severe pain. The only other complications were 1 case of bleeding and 1 of infection. The CO2laser appears to be an acceptable treatment modality for vulvar cancer precursors provided patients are carefully evaluated prior to treatment and invasive carcinoma is ruled out.

ISSN:0029-7844    

出版商:OVID    

年代:1982

数据来源: OVID