摘要:

In the past few years there have been a number of reports correlating a high frequency of herpes simplex virus type 2 (HS V-2) infection with lesions of the uterine cervix. These studies have used a clinical history of herpetic infection or the demonstration of herpetic antibodies in the cancer patients. The present study was performed to evaluate any possible carcinogenic activity of the formalin-inoculated herpes simplex virus type 2 in the reproductive tract of the female mouse. This approach to the study was selected because of previous experience with a model system of carcinogenesis of the cervix uteri using coal tar hydrocarbons. Cytologic and histologic preparations from experimental animals and controls are presented to demonstrate the mucosal alterations and tumors observed in the animals. Nominvasive lesions of the cervix were identified in 76.8% and invasive adenocarcinoma detected in 30.2% of the mice.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

A clinical and histopathologic study of material from a series of 17 patients with basal cell carcinoma of the vulva are reviewed. The tumors occurred primarily in elderly patients (average age, 59 years), the majority of whom were Caucasian. Presenting symptomatology consisted primarily of pruritis vulvae and/or the presence of a vulvar mass (79%) of long duration (average, 6 years, 7 months). The lesions were described grossly as ulcerations or masses located on the anterior Iabium majus. Etiologies were indeterminate although 2 patients had previously received vulvar irradiation. Therapy consisted primarily of wide local excision and was effective in that follow-up studies in 16 patients revealed no deaths attributable to basal cell carcinoma. These data indicate that basal cell carcinoma is a locally invasive nonmetastasizing tumor best treated by wide local excision providing the tumor edge does not extend to the margin of excision.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Vulvar Paget's disease is an intraepithelial change which is locally recurrent and has minimal if any propensity to invasion. Its major significance lies in the frequency with which concomitant carcinomas are discovered in association with the vulvar skin lesion. Adenocarcinoma of the vulvar apocrine glands is the most commonly associated tumor. Another apocrine adenocarcinoma, carcinoma of the breast, either antecedent or concomitant, is the second most frequently associated tumor, having been noted in 14 cases of vulvar Paget's disease. A case report illustrating this association is presented, and the importance of preoperative breast screening procedures in all patients with vulvar Paget's disease is demonstrated.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

A series of 343 consecutive cases with the preoperative diagnosis of carcinoma in situ of the uterine cervix treated by cervical conization is presented. In 93% of these patients cervical cytology returned to normal. The follow-up period ranged from 1 to 5 years. There was significantly greater chance for an apparent cure in cases in which histologic evaluation indicated free margins of resection (98%) than in those where the margins were involved by the neoplastic process (70%). Colposcopic evaluation to determine the site for punch biopsies and adequate resection margins could greatly enhance the success of therapeutic conization. The urgent need for conservative management of cervical intraepithelial neoplasia because of its predominance among young women is discussed.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

In 220 women with gynecologic symptoms, endometrial washings were obtained with the Gravlee jet Washer—in 135 outpatients before office curettage without anesthesia or analgesia; in 85 hospitalized patients before fractional dilatation and curettage under anesthesia. The method was simple, inexpensive, virtually painless, and free of complications. Endometrial adenocarcinoma was present in 12 patients; the jet washing samples were diagnostic in 6 of these. Reported variations in diagnostic accuracy for endometrial carcinoma and precancerous phases raise doubts as to the value of this technic in asymptomatic patients. It is valid for screening symptomatic patients provided results other than normal or positive are further evaluated. Laboratory handling and interpretation must be improved if jet washing is to succeed in mass screening programs.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Antigenadetropin (Danazol) was administered to 39 patients with endometriosis diagnosed at laparoscopy and confirmed by laparoscopic biopsy. None of the patients had surgical resection of the lesion prior to the treatment. While on the drug, all patients developed evidence of ovarian suppression both in regard to ovulation and steroidogenesis. The results were evaluated by repeat laparoscopy and biopsy. The extent of the disease was documented before and after treatment by photography and drawing. There was marked decrease in the extent of endometriosis after treatment: 59% of patients had no evidence of disease, 26% had peritoneal adhesions and hemosiderin deposits but no active endometriosis, and 15% had residual endometriosis. Histology in the latter group revealed atrophic changes in the uterine and ectopic endometrium and the evidence of a healing process.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Six cases of chorioangioma of the placenta and a review of relevant literature are presented. The incidence of chorioangiomas is higher than generally realized because many small chorioangiomas are missed in routine examination of placentas. A case of chorioangioma with foci resembling hemangiopericytoma is presented. Cases of large chorioangiomas seem to occur when the placenta is large. Hydramnios is commonly found with large chorioangiomas, and both of these conditions may be conducive to premature births. There is an increased incidence of toxemia in pregnant patients with chorioangiomas, and the condition is unrelated to the size of the tumor. Diligent examination of infants associated with chorioangioma of the placenta is suggested, as these infants may have unsuspected congenital anomalies.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Outpatient uterine curettage has proved to be an effective diagnostic tool and could replace the need for many hospital curettages. The materials needed to perform an outpatient curettage are described. The method was evaluated on 300 patients who underwent conventional hospital curettage under anesthesia 24 hours after the outpatient curettage. The outpatient curettage was evaluated for safety, reliability, economy, effectiveness, and patient acceptance. The results of the two methods compared favorably.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

A number of patients with severe vasomotor symptoms of menopause, specifically hot flashes, are unable to take exogenous estrogens because of intolerance or contraindications. Others achieve less than satisfactory relief of symptoms with estrogen. A double-blind study was established to determine whether depomedroxyprogesterone acetate (DMPA) injeclable (Depo- Provera, Upjohn) could be used as a satisfactory substitute in these patients. The basis of the study was to evaluate clinical impressions that some menopausal patients taking DMPA for other purposes achieved relief from these distressing symptoms. Fifty-seven patients were treated with DMPA, 150 mg IM monthly, and 12 controls were given 1.5 ml sterile saline IM monthly. Serum FSH and LH were measured initially and serially. Clinical response was determined by the patients' estimates of the frequency and severity of their hot flashes. Of 57 patients in the treatment group, 51 (89.5%) were relieved of symptoms compared to 3 of 12 (25%) in the control group. DMPA can be an effective alternate to estrogen therapy in selected menopausal patients.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID

摘要:

Serum levels of testosterone (T), Sa-dihydrotestosterome (DHT), androstenedione (A), dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), 17- hydroxyprogesterone (17-P), and cortisol (F) were measured in 33 hirsute women. Ten were hirsute and eumenorrheic (H-E), and 23 were hirsute and oligomenorrheic or amenorrheic (HOA). Daily morning blood samples were obtained for 6 consecutive days. Dexamethasone (Dex), 2 mg/day was administered starting after venipuncture on the second day and continuing for S days. Human chorionic gonadotropin (hCG) was administered intramuscularly on the afternoon of the fourth and fifth days. The mean levels of all steroids measured under basal conditions in the hirsute women as a group were significantly elevated when compared to nonhirsute premenopausal women. Dehydroepiandrosterone-sulfate was the only steroid which showed significantly different mean levels between the two groups of hirsute women, being higher in the H-O A patients. Individual hirsute patients showed an elevated serum 17-P level as the most consistent finding; it was present in 90% of the patients in both groups. Significantly more H-E patients showed Dexsuppressible DHT (90% vs40%; P<0.05) and A (70% vs 25%; P<0.05) than did H-OA patients. Dex-suppressibility of 17-P was observed in only 20% of the H-E and 15% of H-OA patients. A positive response to hCG was observed in all patients for serum 17-P and in about half or Iess of the patients for the other steroids. These dynamic tests of adrenal suppression and ovarian stimulation suggest that the ovary may be the main source of 17- P overproduction in both groups of patients. Although 17-P has been previously postulated to have androgenic activity, it is not yet known whether this steroid has a causal relationship to hirsutism.

ISSN:0029-7844    

出版商:OVID    

年代:1975

数据来源: OVID