ISSN:1173-8324    

出版商:ADIS    

年代:2002

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:2002

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:2002

数据来源: ADIS

摘要:

The macrolide antibacterials clarithromycin and erythromycin both have a wide spectrum of activity against many common bacterial pathogens that cause respiratory tract infections (RTIs). Erythromycin has been widely used for several decades, but has various pharmacological shortcomings and must be administered every 6 hours. Moreover, erythromycin is not always well tolerated. Clarithromycin is better absorbed and only needs to be administered twice daily. It is also better tolerated than erythromycin. Research has indicated that discontinuation of treatment is less frequent in patients given clarithromycin than in those receiving erythromycin. At the 6th International Conference on Macrolides, Azalides, Streptogramins, Oxazolidinones and Ketolides [Bologna, Italy; January 2001], a poster presentation showed that, overall, clarithromycin was more cost effective than the less expensive erythromycin in the treatment of community-acquired pneumonia (CAP).

ISSN:1173-8324    

出版商:ADIS    

年代:2002

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:2002

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:2002

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:2002

数据来源: ADIS

摘要:

Alefacept ['Amevive'], a fully human fusion protein that targets memory-effector (CD45RO+) T cells, is effective and well tolerated in the treatment of psoriasis when administered by IM injection or as an IV bolus, according to results from two placebo-controlled phase III studies presented at the 60th annual meeting of the American Academy of Dermatology [New Orleans, US; February 2002]. Furthermore, responses achieved with alefacept were durable, with a median duration of 7 months. Repeated courses of alefacept were shown to increase response rates without cumulative toxicity. Other studies presented at the meeting showed that alefacept was nonimmunogenic and did not affect patients' immune responses.

ISSN:1173-8324    

出版商:ADIS    

年代:2002

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:2002

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:2002

数据来源: ADIS