ISSN:1173-8324    

出版商:ADIS    

年代:1995

数据来源: ADIS

摘要:

There appears to be little agreement regarding the interpretation of data from the Multicentre Isradipine/Diuretic Atherosclerosis Study (MIDAS). While the increase in intima-media thickness (IMT) was significantly lower in isradipine recipients than the diuretic group at 6 months, the subsequent rates of increase were similar in the 2 groups for the remaining follow-up period. Consequently, it has been possible to use the results to argue both for and against the antiatherosclerotic activity of isradipine. But now, Dr Göran Berglund and colleagues from Lund University, Malmö, Sweden, are suggesting that factors other than atherosclerosis may be responsible for the large initial increase in IMT seen in the diuretic group.

ISSN:1173-8324    

出版商:ADIS    

年代:1995

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1995

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1995

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1995

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1995

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1995

数据来源: ADIS

摘要:

The development of HIV protease inhibitors led to renewed hope for an effective anti-AIDS treatment. But problems encountered in early studies of the new agents, such as hepatotoxicity, low oral bioavailability and insufficient potency, hampered the research efforts of several companies. However, perseverance has paid off, and a number of drugs with desirable properties are now undergoing extensive investigations. These include saquinavir, A-84538 and VX-478. At 2 recent conferences on antivirals [see main text for details], several speakers expressed their views on the current status of this class.

ISSN:1173-8324    

出版商:ADIS    

年代:1995

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1995

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1995

数据来源: ADIS