ISSN:1173-8324    

出版商:ADIS    

年代:1994

数据来源: ADIS

摘要:

Linking antifibrin antibodies with plasminogen activators or antithrombotic drugs is an exciting new approach in the quest to produce more effective and specific anticoagulant agents. Encouraging results have been obtained from preclinical studies with these recombinant hybrids, and with another conjugate molecule that links urokinase with antibodies against platelet GpIIb/IIIa receptors and damaged endothelium. A novel, orally-active, direct thrombin inhibitor, CVS-1123, is also attracting interest. Details of these agents, a new platelet GpIIb/IIIa receptor inhibitor, MK-383, and the rationale for using fibrin-targeted conjugates, were presented at the 67th Scientific Sessions of the American Heart Association [Dallas, US; November 1994].

ISSN:1173-8324    

出版商:ADIS    

年代:1994

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1994

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1994

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1994

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1994

数据来源: ADIS

摘要:

Researchers are utilising a variety of approaches in the quest for more effective treatments for neurodegenerative diseases and CNS disorders. Of particular note at the 13th International Symposium on Medicinal Chemistry [Paris, France; September 1994] were new muscarinic agonists and prolyl endopeptidase inhibitors for dementia, and a novel anxiolytic from Servier. The idea of using melatonin agonists to control sleep disturbances was also discussed, with evidence of potential benefit provided by animal studies of S-20098.

ISSN:1173-8324    

出版商:ADIS    

年代:1994

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1994

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1994

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1994

数据来源: ADIS