ISSN:1173-8324    

出版商:ADIS    

年代:2000

数据来源: ADIS

摘要:

Osteoporosis appears to be more aggressive, and progress more quickly, than many clinicians previously thought, according to new data released during the UK National Osteoporosis Society's (NOS) Conference [Bath, UK; April 2000]. Delegates also heard that risedronic acid [risedronate; 'Actonel'] is the first osteoporosis treatment proven to reduce fracture risk within this period in a large group of patients. In light of recent question marks concerning the cardiovascular benefits of hormone replacement therapy (HRT), a leading specialist suggests that the findings might redefine the relative roles of current antiosteoporosis treatments.

ISSN:1173-8324    

出版商:ADIS    

年代:2000

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:2000

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:2000

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:2000

数据来源: ADIS

摘要:

Mammalian cell cycle control and signal transduction pathways are usually perturbed in the genesis and progression of cancer, causing the cancerous cell to be locked into an active proliferative state. Increased understanding of these processes has led to the development of pharmaceutical agents designed to intervene at specific molecular steps involved in carcinogenesis. These agents include inhibitors of cell cycle progression, inhibitors of tyrosine kinase receptors and inhibitors of other molecules involved in intracellular signal transduction such as farnesyltransferase. It is hoped that such agents will, due to their specificity, be both more effective and less toxic than conventional nonspecific chemotherapy. At the 91st Annual Meeting of the American Association for Cancer Research (AACR) [San Francisco, US; April 2000], some encouraging results in this field were presented, including Glaxo Wellcome's GW 8510, a potential preventative treatment for chemotherapy-induced alopecia, data from Roche's new cell cycle inhibitor RO 317453 and an update on Novartis' tyrosine kinase inhibitor STI 571.

ISSN:1173-8324    

出版商:ADIS    

年代:2000

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:2000

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:2000

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:2000

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:2000

数据来源: ADIS