ISSN:1173-8324    

出版商:ADIS    

年代:1998

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1998

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1998

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1998

数据来源: ADIS

摘要:

Economic analysis of phase III clinical data indicates that anastrozole is a cost-effective treatment for patients with advanced breast cancer. Anastrozole was associated with an incremental cost-effectiveness ratio of £1608 per additional life-year gained, compared with megestrol, reported Mr JS Brown from Zeneca Pharmaceuticals, UK, at the First European Conference on the Economics of Cancer [Belgium, Brussels; November 1997]. For most patients with advanced disease, the main aim of treatment is palliation, using endocrine therapy to restrict tumour growth and minimise symptoms.*Until recently, standard second-line therapy has been with either a progesterone (e.g. megestrol or medroxyprogesterone) or a nonspecific aromatase inhibitor (e.g. aminoglutethimide).

ISSN:1173-8324    

出版商:ADIS    

年代:1998

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1998

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1998

数据来源: ADIS

摘要:

It is generally agreed that no currently available drugs, including disease-modifying antirheumatic drugs (DMARDs), can reverse or halt the progression of rheumatoid arthritis (RA). In addition, DMARDs are slow to produce clinical benefits and have potentially serious adverse effects. It is not surprising, therefore, that rheumatologists are excited about new clinical trial results supporting prior evidence that treatments directed against tumour necrosis factor (TNF)-&agr; may be able to slow or even arrest progressive joint destruction in patients with RA.*The latest clinical efficacy and safety data with 2 biological agents that neutralise the activity of TNF-&agr;, Immunex's TNFR-Fc p75 fusion protein [‘Enbrel’] and Centocor's infliximab [CenTNF, ‘Avakine’], were presented at the 1997 Annual Meeting of the American College of Rheumatolog [Washington DC, US; November 1997].

ISSN:1173-8324    

出版商:ADIS    

年代:1998

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1998

数据来源: ADIS

ISSN:1173-8324    

出版商:ADIS    

年代:1998

数据来源: ADIS