ISSN:1062-4821    

出版商:OVID    

年代:1995

数据来源: OVID

ISSN:1062-4821    

出版商:OVID    

年代:1995

数据来源: OVID

ISSN:1062-4821    

出版商:OVID    

年代:1995

数据来源: OVID

ISSN:1062-4821    

出版商:OVID    

年代:1995

数据来源: OVID

摘要:

The aquaporin water channels are expressed in various fluid-transporting epithelia. Physiological and genetic investigations have revealed that aquaporin channel-like intrinsic protein is expressed in numerous tissues, but its significance in water transport physiology is unclear. It has been shown that aquaporin-collecting duct is a vasopressin-responsive water channel, and that it is regulated by a membrane shuttle mechanism. Three unique models for a water pore have been presented but further studies will be required to verify them. New aquaporin members have been isolated and their discrete localization may reflect their specific physiological roles.

ISSN:1062-4821    

出版商:OVID    

年代:1995

数据来源: OVID

摘要:

This review discusses the molecular identites and functional properties of sodium-independentCI--HCO3- exchangers in the kidney. The main sites of renalCh-HCO3- exchange are in the intercalated cells of the collecting duct. The function ofCI--HCO3- exchange is to provide a pathway for base efflux to balance the ATP-driven H+ efflux in cells that carry out transcellular net transport of H+. In the a-intercalated cell, which secretes H+ into the lumen, there is now excellent evidence that the basolateralCI--HCO3- exchanger is an N-terminal truncated form of the erythrocyte anion exchanger 1 (band 3) protein. In the p-intercalated cell, which secretesHCO3-, it is well established that there is aCh-HCO3- exchanger in the apical membrane. Functional, immunocytochemical, and biochemical evidence indicate that the apicalCI--HCO3- exchanger is not a product of the anion exchanger 1 gene. The identity of this protein remains uncertain.

ISSN:1062-4821    

出版商:OVID    

年代:1995

数据来源: OVID

摘要:

Potassium channels are membrane proteins that allow the passive diffusion of potassium down its electrochemical gradient. They play a critical role in many cellular processes and have, therefore, been extensively studied. Over the past several years, the molecular structures of several types of potassium channels have been elucidated. This review investigates the most recent findings regarding the structure, regulation and pathophysiology of potassium channels.

ISSN:1062-4821    

出版商:OVID    

年代:1995

数据来源: OVID

摘要:

Cloning studies have characterized a large gene family of facilitative glucose transporters that are expressed in a tissue-specific manner, and at least two sodium-glucose co-transporters in brush-border membranes of intestinal and renal epithelia. These different transporters play specific roles in glucose transport and homeostasis because of their different tissue distribution, kinetic properties, and regulation of function. This review discusses recent advances in the study of glucose transporters and the regulation of their expression in the normal kidney and in diabetes.

ISSN:1062-4821    

出版商:OVID    

年代:1995

数据来源: OVID

摘要:

This review focuses on two main aspects of amino acid transport. One aspect is the role of the basic amino acid transporter gene in causing cystinuria, its functional properties, and its potential transport functions. The other is the regulation of amino acid transporters at the levels of information processing and cellular organization.

ISSN:1062-4821    

出版商:OVID    

年代:1995

数据来源: OVID

摘要:

Sodium excretion, one of the most important homeostatic functions of the body, is modulated by a number of autocrine, paracrine and endocrine factors that act by altering the balance in complex signalling networks in tubular cells. It is probable that most, if not all, integral membrane proteins that transport sodium are regulated by signals from such networks. The activity of the sodium-transporting proteins may be modified by the phosphorylation/dephosphorylation process, or by other means of protein modification. The rate of transport may also be dynamically regulated by other post-translational processes, such as recruitment of the sodium-transporting proteins to the membrane. The identification of the signalling networks that regulate the tubular sodium transporters and of the regulatory sites in these sodium-transporting proteins will bring further insights into the pathophysiology of salt-sensitive hypertension.

ISSN:1062-4821    

出版商:OVID    

年代:1995

数据来源: OVID