ISSN:1350-7540    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:1350-7540    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:1350-7540    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:1350-7540    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:1350-7540    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

The genetic analysis of multiple sclerosis has been based mainly on candidate gene association studies in selected populations. However, the candidate gene approach, although straightforward, is problematic in diseases of unknown or partially known etiology. With the advent of genomic screening and novel statistical approaches, it is possible now to perform an efficient screen of the entire human genome to identify the genetic components of multiple sclerosis.

ISSN:1350-7540    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system of putative autoimmune origin. In the present review the hypothesis that autoimmunity against multiple different brain antigens can lead to T-cell mediated brain inflammation and that multiple different immunological mechanisms may be responsible for the destruction of myelin is highlighted. The multitude of possible pathogenetic mechanisms is reflected in multiple sclerosis patients by a broad spectrum of disease susceptibility genes and by a profound heterogeneity of pathology and immunopathogenesis of the lesions.

ISSN:1350-7540    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

A variety of therapeutic approaches aimed towards promoting myelin repair in multiple sclerosis and in other demyelinating diseases are now on the brink of clinical implementation. In this article, the extensive experimental studies of the past 2 decades, and in particular the considerable progress made over the last 12 months, will be briefly reviewed. A number of hurdles remain, together with practical and ethical problems which may be more difficult to solve; nevertheless, increasing excitement is apparent in this novel therapeutic field, and the rapid progress emerging from these laboratory based studies justifies a cautious optimism towards the successful translation of remyelination strategies from experimental neurobiology to clinical neurology.

ISSN:1350-7540    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

The past 12 months have witnessed a considerable number of new publications of the results of phase I, II and III trials of new, putative disease modifying therapies in multiple sclerosis. Some important reports have appeared concerning the development and optimization of clinical and magnetic resonance imaging methods for measuring therapeutic outcome. A general sense of optimism continues to exist that there will be further progress in coming years in achieving more effective strategies for treating symptoms, and for preventing relapses and disease progression.

ISSN:1350-7540    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

The essential difference between classical multiple sclerosis and both Devic's neuromyelitis optica and acute disseminated encephalomyelitis are outlined. Advances in identifying the multiple gene mutations responsible for adrenoleukodystrophy and possible mechanisms for the genotypic/phenotypic variability are reviewed.

ISSN:1350-7540    

出版商:OVID    

年代:1997

数据来源: OVID