1. |
Bibliography Current World Literature |
|
Current Opinion in Neurology,
Volume 10,
Issue 2,
1997,
Page 29-53
Preview
|
PDF (3530KB)
|
|
ISSN:1350-7540
出版商:OVID
年代:1997
数据来源: OVID
|
2. |
The explosion of neurogenetics |
|
Current Opinion in Neurology,
Volume 10,
Issue 2,
1997,
Page 77-84
Orest Hurko,
Preview
|
PDF (651KB)
|
|
ISSN:1350-7540
出版商:OVID
年代:1997
数据来源: OVID
|
3. |
The battle against the Sacred Disease heats uprecent advances in the understanding and treatment of epilepsies |
|
Current Opinion in Neurology,
Volume 10,
Issue 2,
1997,
Page 85-87
James McNamara,
Preview
|
PDF (257KB)
|
|
ISSN:1350-7540
出版商:OVID
年代:1997
数据来源: OVID
|
4. |
Magnetic resonance and functional magnetic resonance imagingtools for the study of human epilepsy |
|
Current Opinion in Neurology,
Volume 10,
Issue 2,
1997,
Page 88-91
Ruben Kuzniecky,
Preview
|
PDF (318KB)
|
|
摘要:
The development of new magnetic resonance imaging base neuroimaging techniques is increasing the utility and the importance of magnetic resonance imaging in the investigation of patients with epilepsy. Recent advances in magnetic resonance imaging, magnetic resonance spectroscopy and functional magnetic resonance imaging are not only providing relevant clinical information regarding human epilepsy but are also revealing important insights into its basic mechanisms. In the present review the role of these new technologies is discussed in the context of their clinical utility.
ISSN:1350-7540
出版商:OVID
年代:1997
数据来源: OVID
|
5. |
Mechanisms underlying neuronal migration disorders and epilepsy |
|
Current Opinion in Neurology,
Volume 10,
Issue 2,
1997,
Page 92-97
Alexander Flint,
Arnold Kriegstein,
Preview
|
PDF (611KB)
|
|
摘要:
Neuronal migration disorders are often associated with intractable epilepsy. These cortical malformations are quite heterogeneous, suggesting that they may result from interference with a diverse set of processes during corticogenesis. Progress toward understanding the pathophysiologic basis of these disorders is coming from research into the basic mechanisms of corticogenesis, animal models of cortical malformations, and molecular genetic approaches to migration disorders.
ISSN:1350-7540
出版商:OVID
年代:1997
数据来源: OVID
|
6. |
New nuclear magnetic resonance data in epilepsy |
|
Current Opinion in Neurology,
Volume 10,
Issue 2,
1997,
Page 98-102
James Prichard,
Preview
|
PDF (458KB)
|
|
摘要:
Nuclear magnetic resonance methods as a whole have contributed as much to the study and treatment of epilepsy as to any branch of medicine. The pace of the progress in this field increases as recently developed nuclear magnetic resonance techniques mature into practical tools for epilepsy research and management. Recent examples of such progress include new data on seizure-related brain water diffusion changes, brain metabolic abnormalities in epileptic patients, and pharmacologic manipulation of brain gamma-aminobutyric acid.
ISSN:1350-7540
出版商:OVID
年代:1997
数据来源: OVID
|
7. |
Mossy fiber reorganization in the epileptic hippocampus |
|
Current Opinion in Neurology,
Volume 10,
Issue 2,
1997,
Page 103-109
Jack Parent,
Daniel Lowenstein,
Preview
|
PDF (652KB)
|
|
摘要:
Reorganization of dentate granule cell axons (mossy fibers) is a prominent aspect of the pathological changes observed in human temporal lobe epilepsy. Although recent work has begun to address the significance of mossy fiber reorganization, the specific and overall functional consequences of these network changes remain poorly understood. New studies are beginning to provide insight into molecular mechanisms underlying this process. Advances in our understanding of the causes and effects of mossy fiber reorganization are likely to provide insight into the pathophysiology of temporal lobe epilepsy, as well as the larger issue of network remodeling following nervous system injury.
ISSN:1350-7540
出版商:OVID
年代:1997
数据来源: OVID
|
8. |
Genetics of human partial epilepsy |
|
Current Opinion in Neurology,
Volume 10,
Issue 2,
1997,
Page 110-114
Samuel Berkovic,
Ingrid Scheffer,
Preview
|
PDF (400KB)
|
|
摘要:
A minor genetic predisposition to partial epilepsy has been long recognized. Recently, a group of idiopathic partial epilepsies with autosomal dominant inheritance has been identified. The clinical features and molecular genetic findings in these epilepsies are outlined in the present review. The first genetic defect in an idiopathic epilepsy has been found in autosomal dominant nocturnal frontal lobe epilepsy, the archetype of this newly recognized group of inherited partial epilepsies.
ISSN:1350-7540
出版商:OVID
年代:1997
数据来源: OVID
|
9. |
Generalized epilepsiesemerging insights into cellular and genetic mechanisms |
|
Current Opinion in Neurology,
Volume 10,
Issue 2,
1997,
Page 115-120
David Hosford,
Sarah Caddick,
Fu-hsiung Lin,
Preview
|
PDF (437KB)
|
|
摘要:
In the past year we have gained significant insights into the molecular and genetic mechanisms underlying generalized absence seizures, primarily through the study of animal models. Also a new understanding has emerged about the genetic bases of certain syndromes in which generalized myoclonic and tonic–clonic seizures are expressed. New insights into these different types of generalized seizures may lead eventually to new therapies.
ISSN:1350-7540
出版商:OVID
年代:1997
数据来源: OVID
|
10. |
Mechanisms of action of new antiepileptic drugs |
|
Current Opinion in Neurology,
Volume 10,
Issue 2,
1997,
Page 121-128
Robert Macdonald,
L. Greenfield,
Preview
|
PDF (380KB)
|
|
摘要:
Many new antiepileptic drugs have been developed to treat seizure disorders. The established antiepileptic drugs reduce neuronal excitability by promoting sodium channel inactivation, inhibiting T-type calcium channels, or enhancing gamma-aminobutyric acid type A receptor-mediated inhibition. Several of the newer agents employ similar mechanisms, whereas others may enhance gamma-aminobutyric acid-ergic inhibitory systems or inhibit glutamatergic excitatory neurotransmission, and may be neuroprotective or antiepileptogenic.
ISSN:1350-7540
出版商:OVID
年代:1997
数据来源: OVID
|