摘要:

Type IC antiarrhythmic agents have unique properties on cardiac tissue. These agents tend to have important effects on phase 0 depolarization and therefore, from an electrocardiographic point of vieia, prolong the QRS complex. Their effect on repolarization is less than that of type IA agents, thus, they generally do not prolong the JT interval, that is the QT minus the QRS. Electrophysiologically, type IC agents prolong refractoriness in many cardiac tissues including atrium, AV node, and ventricle. These unique properties are the focus of this review.

ISSN:0892-1059    

DOI:10.1111/j.1540-8167.1987.tb01435.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

In order to confirm that variations in the plasma levels of propafenone in patients receiving the same daily dose are polyrnorphically distributed in relation to oxydative metabolism, the relationship between propafenone administration and debrisoquine metabolic phenotype was studied in two series of Caucasian patients with chronic supraventricular or ventricular arrhifthmias. In a first series of 16 Caucasian patients treated with propafenone, the poor metabolizer phenotype appeared to be more than 90%. In a second series of 13 Caucasian patients, two debrisoquine tests were performed: the first phenotype determination of debrisoquine hydroxylation ability was done without propafenone administration and the second determination when a steady state concentration of propafenone was reached. Of the 10 extensive metabolizers (determined without propafenone treatment), 7 patients became apparent poor metabolizers while considering the debrisoquine test during propafenone treatment with a general shift of the 13 studied patients to the upper values of log of the metabolic ratiodebrisoquine/4‐OH debrisoquine———‐suggesting deficiency in metabolizing debrisoquine. This study seems to indicate the presence of a common hydroxylation for propafenone and debrisoquine, which probably compete in the pathway. This metabolic competition should therefore be taken into consideration during phenotypic determination of hydroxylatio

ISSN:0892-1059    

DOI:10.1111/j.1540-8167.1987.tb01436.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

We report a case of escape‐capture bigeminy, a rare form of arrhythmia, occurring after treatment of wide‐QRS tachycardia and diagnosed by esophageal electrocardiography recording of atrial activity which was not evident on the surface electrocardiog

ISSN:0892-1059    

DOI:10.1111/j.1540-8167.1987.tb01437.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY