ISSN:8755-1039    

DOI:10.1002/dc.2840010202

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractThis retrospective study consisted of 55patients with histologically confirmed metastatic cancer to the lung. Cytologic specimens were collected within 45 days before death. These included bronchial secretions, pleural effusions, and fine needle aspirations obtained randomly, either singly or in various combinations. The cytodiagnosis of cancer was made in 58% (32/55) of the patients. Originally, 34% (11/32) of these had been false‐negative cases. Morphologic features associated with cytologic negativity in 23 patients included apparent failure to invade the respiratory air compartment in 57% (13/23) of the cases; when applicable, failure to induce a pleural effusion with neoplastic invasion of pleural tissues in 75% (6/8); peripheral distribution of the metastatic nodules to the outer third of the pulmonary parenchyma in 26% (6/23); and tumor size of less than 1.5 cm in 57% (13/23

ISSN:8755-1039    

DOI:10.1002/dc.2840010203

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractTissue repair is a common biologic process closely associated with the inflammatory response. The cytologic features of regeneration and repair of epithelial surfaces have been intensely studied and documented. Regeneration and repair occur in mesenchymal tissues and their radiographic and cytologic findings may closely simulate malignancy. This paper reviews the cytologic features of mesenchymal repair as seen in 44 aspiration biopsy specimens of bone, skeletal muscle, fibroadipose tissue, and fibrous connective tissue. In general, cytologic specimens from such lesions display variable but often scanty cellularity, prominent cellular heterogeneity with a spectrum of atypical features, an admixture of reactive fibroblasts, and evidence of a coexisting inflammatory reaction. Careful attention to cytologic detail and review of clinical and radiographic findings are mandatory in the evaluation of these specimens.

ISSN:8755-1039    

DOI:10.1002/dc.2840010204

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractThe osteoclastic giant cell tumor of the pancreas is a rare primary neoplasm that by light and electron microscopy mimics giant cell tumor of bone. In the proper clinical setting, this lesion can be diagnosed by fine needle aspiration. Review of 10 cases reveals a female predominance, a median survival of 12 months, and a tendency for local invasion, rather than lymphatic or distant metastasis, and for invasion of large veins. An epithelial origin is favored for this malignant neoplasm, which expresses varying degrees of mesenchymal differentiation.

ISSN:8755-1039    

DOI:10.1002/dc.2840010205

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractTwenty‐three patients with radiologic diagnoses of giant cell tumor of bone underwent fine needle aspiration cytology and needle biopsy for tissue diagnosis before curettage or resection. One patient had two tumors, making a total of 24 cases. The accuracy of the cytologic diagnosis was compared with that of tissue biopsy. Cytologically there were mononucleated and multinucleated cells. The former often occurred in clusters or, less often, were dispersed. They had spindle or plump cell bodies with moderate amounts of cytoplasm and well‐defined cytoplasmic membranes. The oval nuclei demonstrated fine, evenly distributed chromatin and small nucleoli. The multinucleated cells were osteoclastlike and were associated with the clusters of mononucleated cells or lying freely. They had a well‐demarcated cytoplasm and contained from a few to several dozen monomorphic nuclei. Cytologic diagnosis was made in 20 of 24 cases, and histologic diagnosis was made in 21 of 24. Insufficient diagnostic material for cytology was the reason for failure in 4 cases. This was attributed to faulty technique (2 cases), cystic change (1 case), and massive necrosis (1 case). As other benign and malignant bone tumors may contain benign giant cells, cytologic or histologic findings alone are not diagnostic of giant cell tumor of bone, but should be complemented with the clinicoradiologic findings. Aspiration cytology is as accurate as tissue needle biopsy, may be of high diagnostic value in deeply located lesions not amenable to cutting needle biopsy, and should be done with full knowledge of the clinicoradiographic inform

ISSN:8755-1039    

DOI:10.1002/dc.2840010206

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractA case of primary pineal germinoma with widespread extracranial metastasis in a 36‐year‐old man is presented. A clinical work‐up revealed bilateral pleural effusions, ascites, and metastatic lesions involving the lung. Cytology and electron microscopic study of the pleural and ascitic fluid and of the fine needle aspiration material revealed metastatic germinoma. Although the cytologic features were not distinct from those of anaplastic carcinoma, they were distinguishable from those of glial neoplasms, lymphoma, and sarcoma. The computed tomography findings, elevated human chorionic gonadotropin level, and electron microscopic features contributed significantly to the diagnosis of extracranial metastasis of the pineal germinoma. Metastatic spread most likely occurred via the ventriculoperitoneal

ISSN:8755-1039    

DOI:10.1002/dc.2840010207

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractFine needle biopsy is generally considered unreliable in the differential diagnosis of follicular lesions of the thyroid gland. To test this hypothesis, we correlated fine needle biopsy diagnoses with surgical diagnoses in 379 follicular lesions. From nuclear characteristics (especially size) and the architectural pattern of tissue fragments, the following observations were made. Differentiation of goiters (including hyperplastic ones) from neoplastic thyroid disease is quite accurate and no more than 1 to 2% of cancers should be missed. The specific cytologic diagnosis of follicular carcinoma is 75% accurate, and that of follicular variant of papillary carcinoma is over 95% accurate. Of histologically proved follicular carcinomas, almost three‐quarters should be diagnosed as such or strongly suspected by fine needle biopsy. The remainder will be identified as cellular follicular adenomas, reaffirming the overlap of cytologic features of benign and malignant neoplastic disease. From cytologic and surgical pathologic data for each fine needle biopsy diagnosis of follicular lesion, a probability of cancer can be stated that is useful in management decision

ISSN:8755-1039    

DOI:10.1002/dc.2840010208

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractA new amplification technique is described for the detection of small amounts of antigen in ethanol‐fixed cytologic specimens and formalin‐fixed tissues. By adding a third antibody layer to the already sensitive avidin‐biotin immunoperoxidase system. we have demonstrated a considerable increase in both the quantitative and qualitative aspects of this immunostaining method. In evaluating this technique, we employed a previously defined small cell lung carcinoma cell surface antigen system and monoclonal antib

ISSN:8755-1039    

DOI:10.1002/dc.2840010209

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractA review of radiation‐induced atypia is presented. The radiation changes are divided into acute, intermediate, and late. The presence of cancer cells following irradiation is divided into persistent carcinoma, early recurrent carcinoma, and late recurrent carcinoma. The features of each group are described, supplemented by illustrations depicting the changes. The cytologic changes of radiation are discussed by correlating the light microscopic features with the electron microscopic findings in 8 cases that were studied ultrastructurall

ISSN:8755-1039    

DOI:10.1002/dc.2840010210

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractThe clinicopathologic features of a case of scar endometriosis are presented. The lesion is unusual in that it occurred in a black woman following tubal surgery for ectopic pregnancy. The case appears to be unique in that the endometriotic focus was characterized by the presence of mucinous metaplasia. Diagnosis of this histopathologic curiosity was made by fine needle aspiration cytology.

ISSN:8755-1039    

DOI:10.1002/dc.2840010211

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY