摘要:

AbstractWe herein report the cytologic and histotogic findings in 11 cases of cytologically atypical fibroadenoma (FA). These ranged from cases recognizable as FA but showing epithelial atypia to cases that, even on review, completely mimicked the needle aspiration picture of ductal breast carcinoma. A retrospective review of 45 cases of previously excised FA showed that focal atypia is common (27%). Possible physiologic explanations for atypia in FA, along with strategies for avoiding false diagnoses of malignancy in aspiration smears, are discussed.

ISSN:8755-1039    

DOI:10.1002/dc.2840060602

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1990

数据来源: WILEY

摘要:

AbstractOf 2,012 fine‐needle aspirations (FNAs) of the thyroid performed between the years 1984 and 1988, detailed cytomorphologic analysis of 95 cases diagnosed as neoplastic on histology and/or cytology and those that received an equivocal cytodiagnosis are presented in this article. Discussed are medullary thyroid carcinomas (nine cases), clinically anaplastic thyroid tumors (CATT; eight cases), two cases of non‐Hodgkin's lymphoma (NHL), and one primary leiomyosarcoma of the thyroid, for a total of 20 cases. Included in the category of CATT are all the thyroid tumors presenting clinically with an anaplastic growth pattern. The cytomorphology of these tumors varied, but the giant‐ and spindle‐cell pattern was predominant. An accurate cytodiagnosis was possible, as per cytohistologic correlation, in seven cases, while in one case histological material was not available for study. Medullary carcinoma of the thyroid (MCT) showed a mixed spindle‐cell and round‐cell population in eight cases and an entirely spindle‐cell population in one case. All cases of MCT were correctly diagnosed on cytology, and amyloid could be demonstrated in the cytologic smears in three cases. The cases of NHL and leiomyosarcoma could also be correctly interprete

ISSN:8755-1039    

DOI:10.1002/dc.2840060603

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1990

数据来源: WILEY

摘要:

AbstractThree cytologic urine specimens from separate patients seen over a period of 3 mo were prepared by the Papanicolaou method. They contained crystals (uric acid type in two and magnesium ammonium phosphate in one) that incorporated variable amounts of organic (mucoprotein) matrix; many appeared by light microscopy to be made exclusively of matrix. Scanning electron microscopy performed in one of the specimens containing uric acid crystals suggested that the matrix forms were in progressive stages of mineralization. These cases, plus a similar one reported recently by us, demonstrate that the detection by urine cytology of organic matrix incorporated in the structure of urinary crystals is not rare and that the Papanicofaou staining method facilitates such detection.

ISSN:8755-1039    

DOI:10.1002/dc.2840060604

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1990

数据来源: WILEY

摘要:

AbstractTwenty‐eight patients with chondrogenic tumors—2 chondroblastomas, 4 chondromas, 18 chondrosarcomas, 1 clear‐cell chondrosarcoma, and 3 mesenchymal chondrosarcomas—underwent fine‐needle aspiration biopsy (FNAB) in the preoperative investigation. The cytologic features in smears were compared with the histopathologic findings in the surgical specimens; in 14 cases they were also compared with the light and electron microscopic findings in resin‐embedded fine‐needle aspirates. The smears of the vast majority of the classical chondrosarcomas presented features that made possible the FNAB diagnosis of a chondrogenic tumor to be made. In the case of the low‐grade chondrosarcomas in particular, which were poorly or moderately cellular in smears and showed chondroblastic cells often in lacunary structures of hyaline matrix, consideration of the clinical presentation, size, location, and roentgenographic appearance was essential for the diagnosis of chondrosarcoma. On the other hand, the high‐grade chondrosarcomas presented cytologic features that clearly indicated their malignancy and they usually had a myxoid matrix. The possible differential diagnoses that may arise from the FNAB diagnosis of cartilaginous tumors are discussed. The resin‐embedding technique for the light and electron microscopic examination of FNABs. along with the histochemical analysis for the demonstration of sulphated glucosaminoglycans and the immunocytochemistry applied to smears, was found to be of value in the definite diagnosis, especially in the distinction of chondrogenic tumors from chordoma and metastatic mucous

ISSN:8755-1039    

DOI:10.1002/dc.2840060605

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1990

数据来源: WILEY

摘要:

AbstractIn the past decade, over 100,000 cases of the acquired immunodeficiency syndrome (AIDS) have been reported in the United States. Conservative estimates suggest that 1.5 million people are infected with the human immunodeficiency virus (HIV), the etiologic agent of AIDS. Major metropolitan areas, such as Los Angeles, have experienced a rapid increase in the number of AIDS cases. At the Los Angeles County–University of Southern California Medical Center, we have gained significant insight into the cytologic findings associated with HIV infection. Based on our experience, we herein review the technical and morphologic evaluation of alimentary tract cytology specimens from this patient populatio

ISSN:8755-1039    

DOI:10.1002/dc.2840060606

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1990

数据来源: WILEY

摘要:

AbstractThis article presents a rare case of well‐differentiated liposarcoma of the paratesticular area (spermatic cord) with a preoperative cytological diagnosis. A 0.6‐mm fine‐needle aspiration biopsy (FNAB) of a paratesticular lump showed many spindle and polygonal atypical cells with numerous cytoplasmic vacuoles. On the basis of a diagnosis of “malignant mesenchymal neoplasia consistent with liposarcoma,” the patient underwent radical orchiectomy. A 8 × 7 × 8.5 cm, whitish mass was found, which was histologically classified as a “well‐differentiated liposarcoma” (with lipoma‐like, sclerosing, and myxoid areas), according to the classification of Enzinger and Weiss. A review of the lite

ISSN:8755-1039    

DOI:10.1002/dc.2840060607

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1990

数据来源: WILEY

摘要:

AbstractFine needle aspirates from one of multiple liver nodules revealed a large number of discohesive malignant cells with abundant vacuolated cytoplasm. The patient had had left eye enucleation the year before, for a melanoma with focal areas of clear cell change. Pap stained preparations from the liver FNA displayed well the nuclear features of balloon cell melanoma, including anisonucleosis, prominent nucleoli and intranuclear inclusions. Diff‐Quik stain demonstrated best the cytoplasmic features such as distinct cell margins and finely dispersed and sharply delineated clear vacuoles. No pigmentation was noted but melanoma was suspected after the history prompted comparison with the enucleated specimen resected a year previously. A multimodal battery of ancillary methods including electron microscopy (EM) and immunocytochemistry (ICC) allowed the confirmation of balloon‐cell melanoma, a rare variant not previously described in the eye. By EM, abundant lipids were identified along with melanin‐containing structures resembling melanosomes. S‐100 positivity along with negativity for epithelial, lymphohistiocyte and germ cell markers was compatible with melanoma, These findings are consistent with the view that cytologic detection of poorly cohesive, hypervacuolated cells does not exclude the possibility of melanoma. This rare example of a lipid‐containing melanoma stresses the value of obtaining good clinical history, comparing FNAs to any pre‐existing material and utilizing a multimodal approach to cytologic diagnosis in s

ISSN:8755-1039    

DOI:10.1002/dc.2840060608

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1990

数据来源: WILEY

ISSN:8755-1039    

DOI:10.1002/dc.2840060609

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1990

数据来源: WILEY

ISSN:8755-1039    

DOI:10.1002/dc.2840060610

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1990

数据来源: WILEY

ISSN:8755-1039    

DOI:10.1002/dc.2840060601

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1990

数据来源: WILEY