摘要:

AbstractEditorial Comments:A vital topic that will impact on cytopathologists doing fine‐needle aspiration is discussed in the following two editorials: “Diagnosis of Palpable Breast t Cancer by FNA: A Changing Role?” by Lydia P. Howell, M.D., and “Occult Breast Lesions and Aspiration Biopsy: A New Challenge” by Shahla Masood, M.D. One concerns the aspiration of palpable lesions and the second, occult; but, the problem is the same in both. Will aspiration biopsy of the breast be replaced by core biopsy? This is already the case in prostatic biopsies. To many, this represents a step backward, particularly in view of the tremendous progress made by aspiration biopsy of the breast. This progress is especially evident in this issue of Diagnostic Cytopathology with an additional six articles covering the cytology of reactive, proliferative, and neoplastic breast diseases in both sexes. To prevent the premature demise of aspiration biopsy of the breast, cytopathologists must firstly, be aware of the situation; secondly, be comfortable in the interpretation of aspiration biopsy; and thirdly, be knowledgeable in the advantages of each procedure. During the coming months, a number of papers will address this critical issue. Let us hear from our r

ISSN:8755-1039    

DOI:10.1002/dc.2840090602

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1993

数据来源: WILEY

ISSN:8755-1039    

DOI:10.1002/dc.2840090603

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1993

数据来源: WILEY

摘要:

AbstractVideo‐enhanced optical microscopy objectively confirms that immunocytochemical biomarker supplementation of routine cytology permits separation of (1) “pre”‐cancer epithelial cells from JHLP screened individuals who subsequently developed lung cancer from (2) similarly atypical epithelial cells from JHLP participants who did not. The establishment of a bank of sputum cytology specimens along with a data respository of 5‐yr follow‐up and clinical outcome had permitted banked specimens to be immunostained and scored against a gold standard of subsequent histologic lung cancer. A highly skilled cytopathologist, interpreting immunostained screening sputum specimens and blinded to the clinical outcome, originally was able to correctly predict clinical outcome with 88.7% accuracy compared to this “gold standard” (Tockman et al. J Clin Oncol 1988;6:1685‐1693). This study presents an independent confirmation of that earlier immunocytochemical classification through feature extraction of digitally recorded, transmission optical microscope video images of immunostained, moderately atypical sputum cells from th

ISSN:8755-1039    

DOI:10.1002/dc.2840090604

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1993

数据来源: WILEY

摘要:

AbstractThe diagnostic accuracy of frozen section (FS) examination and intraoperative cytology (IOC) has been compared in two different series of breast biopsies in which only one of the two methods has been used. The intraoperative results have been compared with the final histological diagnoses. Five‐hundred‐ten cases have been investigated by using FS only, and 407 by means of IOC. The two series were comparable because they included the same pathologies; moreover we have subdivided each series into four groups of pathologies to better evaluate the diagnostic accuracy of two methods.The total diagnostic accuracy of FS has been 93.13% vs. 95.‐33% of IOC The value of diagnostic accuracy of FS and IOC in the four sub‐groups substantially overlapped; there was only a little difference in the group of “various lesions” in which the diagnostic accuracy of IOC was higher. No false positive has been observed in IOC. FS have produced one false positive (0.19%), whereas false negatives have amounted to 1.77% for IOC and to 1.72% for FS. Deferred diagnoses have been 2.95% in IOC and 4.90% in FS examination. For both methods according to Galen and Gambino the following values have been calculated: sensitivity, specificity, efficiency, and predictive value. By comparing the data, the value of the cytological examination in the intraoperative diagnoses results is evident mainly when the latter is coupled with the gross observation.Causes of diagnostic errors clearly overlap both in IOC and in FS: (1) lesions with a fibroadenomatous appearance can involve an overdiagnosis or an underdiagnosis; (2) low‐grade lesions like tubular carcinomas or in situ lobular carcinomas can be interpreted as benign; (3) the differential diagnosis of intraductal lesions may be very difficult, and a conservative approach is the best choice; and (4) infiltrating lobular carcinoma may be neglected both in FS and IOC.The few disadvantages of the cytologic method are offset by its low cost, the wider sampling, the possibility of sparing tissue for further investigations (such as steroid receptors, cellular kinetic, electron microscopy, and other biological studies) proved more useful in prognostic evaluation of

ISSN:8755-1039    

DOI:10.1002/dc.2840090605

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1993

数据来源: WILEY

摘要:

AbstractWe describe the morphologic features of 25 cytology specimens (13 fine‐needle aspirates and 12 exfoliative specimens) obtained from nine patients with malignant melanoma of soft parts (MMSP). Analysis of the fine‐needle aspirates and exfoliative specimens revealed primarily a dispersed cell population with occasional cell clustering. Tumor cells were round to polygonal with moderately abundant cytoplasm and had round nuclei with prominent nucleoli. In two cases, an initial definitive diagnosis of MMSP was rendered on material obtained by fine‐needle aspiration with the aid of immunocytochemical and ultrastructural st

ISSN:8755-1039    

DOI:10.1002/dc.2840090606

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1993

数据来源: WILEY

摘要:

AbstractFour cases of non‐Hodgkin lymphoma of thyroid, diagnosed by fine‐needle aspiration (FNA) cytology during a period of 3% yr constituted 0.2% of 1,716 thyroid FNAs and 3.4% of 118 thyroid neoplasms. The age of the patients ranged from 42 to 78 yr with an average of 63 yr and all were females. Three cases had thyroid swellings, and one case had cervical lymphadenopathy and fullness in the thyroid region. The lymphomas were categorized as mixed small and large cell lymphomas, large cell lymphoma, small noncleaved lymphoma (non‐Burkitt‐type), and plasmacytoid lymphoma. Histopathology as well as immunohistochemistry confirmed the cytodiagnosis of lymphoma in the first and fourth cases. In the second case where possibility of anaplastic carcinoma could not be ruled out altogether at initial cytotogic examination, the histopathology report was undifferentiated carcinoma but immunohistochemically it was proved to be a B‐cell

ISSN:8755-1039    

DOI:10.1002/dc.2840090607

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1993

数据来源: WILEY

摘要:

AbstractAt our institution, gynecologists perform Pap smears not only as an initial screening procedure but also at the time of colposcopy and biopsy. We compared the results of initial Papanicolaou (Pap) smears with those taken at colposcopic biopsy to determine if repeating the Pap smear at the time of colposcopy contributed to patient management. We found that repeat colposcopic smears often agreed with the referral smears and biopsies. When there was disagreement, the colposcopic smear was more often a lower grade than the referral smear and correlated best with the biopsy. Both referral and colposcopic smears underestimated the severity of cervical lesions with the same frequency. We could document only 5/414 (1.2%) colposcopic smears that contributed to patient care.

ISSN:8755-1039    

DOI:10.1002/dc.2840090608

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1993

数据来源: WILEY

摘要:

AbstractWe report two cases of fatal, clinically unsuspected disseminated toxoplasmosis that developed following orthotopic cardiac transplantation.Toxoplasma gondiitrophozoites, pseudocysts, and cysts were best visualized on hematoxylin and eosin and Giemsastained cytospin preparations of bronchoalveolar lavage fluid. Post‐mortem examination in both cases revealed disseminated toxoplasmosis with extensive involvement of the lungs and heart. The patients, who were seronegative for antibody toT. gondiiprior to transplantation, received organs from donors whose serology status was unknown. Demonstration of anti‐toxoplasma antibodies post‐transplantation occurred in both cases. Bronchoalveolar lavage may be useful in diagnosis of pulmonary toxoplasmosis. Clinicians, pathologists, and cytopathologists must considerT. gondiiin the differential diagnosis of pneumonia in the immunocompromised patient, especially cardiac transplant pat

ISSN:8755-1039    

DOI:10.1002/dc.2840090609

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1993

数据来源: WILEY

摘要:

AbstractWe report two myoepithelial cell neoplasms; a salivary gland tumor was malignant and a breast neoplasm was benign. Both were studied histologically, immunohistochemically, cytologically, and ultrastructurally. The malignant myoepithelioma recurred twice and metastasized to one regional lymph node. This tumor was infiltrative with areas of necrosis and hemorrhage. It was composed of malignant‐appearing spindle and plasmacytoid cells. Both types of cells were immunoreactive to muscle specific actin, S‐100 protein, cytokeratin, vimentin, and neuron‐specific enolase. Ultrastructurally, features of myoepithelial cells were seen. Fine‐needle aspirate smears showed spindle and plasmacytoid cells, numerous mitoses, and malignant‐appearing nuclei.Spindle‐cell adenomyoepithelioma of the breast, a small well‐circumscribed firm nodule, featured multiple lobules of spindle cells associated with clear‐cell glands at the tabular periphery. Histologically and cytologically, the lesion was cellular but appeared benign. The differential diagnosis of myoepithelial neoplas

ISSN:8755-1039    

DOI:10.1002/dc.2840090610

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1993

数据来源: WILEY

摘要:

AbstractCytological findings are presented of seven cases of cardiac myxomas. Avidin‐biotin‐peroxidase complex (ABC) method was employed to demonstrate Ulex europaeus agglutinin‐I (UEA‐I) lectin in imprint smears as well as in paraffin‐embedded tissue sections in cardiac myxomas.The cytology was characterized by tumor cells with polyhedral or stellate and mucinous background with lymphocytes, neutrophilles, and hemosiderin‐laden machrophages.In smears as well as tissue sections, UEA‐I lectin was detected throughout the cytoplasm of myxoma cells.This study established the applicability of the immunoperoxidase staining for cardiac myxoma as an aid in cytopathologi

ISSN:8755-1039    

DOI:10.1002/dc.2840090611

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1993

数据来源: WILEY