摘要:

AbstractThe infectious pathogens and associated cellular reactions in 75 pulmonary cytological specimens obtained largely by fiberoptic bronchoscopy from 36 patients with the acquired immune deficiency syndrome are described and correlated with the biopsy specimens. An opportunistic pathogen was diagnosed in 33% of cytological preparations. Pneumocystis carinii was encountered most frequently;Cryptococcus neoformansand cytomegalovirus were also seen. The polymorphonuclear neutrophil was the predominant inflammatory cell. Cells of secondary import were bronchial cells and type II pneumocytes with atypia and hyperplasia. Bronchoalveolar lavage had the highest yield, positive predictive value, and sensitivity for all pathogens and forP. carinii. An opportunistic pathogen was diagnosed in 69% of patients utilizing histological material and in 33% using cytological samples; the rate of diagnosis increased to 72% when the samples were combined. Diagn Cytopathol 1986;2:181‐18

ISSN:8755-1039    

DOI:10.1002/dc.2840020302

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1986

数据来源: WILEY

摘要:

AbstractOver a 2‐yr period, 1982‐1984, 181 pulmonary cytology specimens were obtained from 45 patients clinically suspected of having AIDS in an attempt to identify the various organisms and the cytologic atypias present in pulmonary cells. Cytologic correlations with autopsy findings were available for 28 of these cases (62%), Specimens were collected from sputum, bronchial washes and brushes, bronchoalveolar lavages, and pleural fluid. Of the 181 specimens, 121 (67%) were of diagnostic value. Depending on the cytologic technique, Pneumocystis carinii, cytomegalovirus, herpesvirus, and Candida were detected with varying frequency. The bronchial epithelial and glandular cell atypias, ranging from mild inflammatory reactive changes to marked cellular atypia, were noted most often in specimens from patients with pulmonary infections who were concurrently receiving oxygen therapy and/or chemotherapy for Kaposi's sarcoma or central nervous system lymphoma. An awareness of the wide range of AIDS‐associated pulmonary cell atypias is required to rule out a diagnosis of malignancy. Diagn Cytopathol 1986;2:18

ISSN:8755-1039    

DOI:10.1002/dc.2840020303

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1986

数据来源: WILEY

摘要:

AbstractDuring the past two years, our laboratory has introduced a semiquantitative membrane filter approach to cerebrospinal fluid (CSF) cytology. Five hundred and thirty‐five CSF specimens, averaging 3 ml in volume, were placed over 25‐mm diameter Milliporer̀ filters (5‐μ pore size) and stained using a modified Papankolaou method. Each microscopic evaluation consisted of a cell count per milliliter, a 100‐cell differential, and a diagnostic or interpretive statement. Seventy‐four (13.8%) positive, 17 (3.2%) atypical, 439 (82%) negative, and 4(1%) unsatisfactory specimens were evaluated. Seventy‐four percent of the positive or atypical CSF specimens had mononuclear cell counts within the medically accepted normal range of five mononuclear cells per cubic millimeter (chamber count method) or 5,000 cells per milliter (cytologic method). The small‐filter technique offered advantages because it maximized cell retrieval, localized cells, and shortened the time required for microscopic evaluation. Diagn Cytopathol

ISSN:8755-1039    

DOI:10.1002/dc.2840020304

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1986

数据来源: WILEY

摘要:

AbstractEndometrial cytologic samples obtained with Cohen's endocyte from 501 normally menstruating women were studied and correlated with histologic sections from cell blocks. In this article, the cytologic diagnostic criteria for normal cyclic endometrium are pointed out. The diagnostic accuracy of normal cyclic endometrium has been 92%. A possibility of a cytologic dating is discussed. The diagnostic accuracy was 71.8% for early proliferative endometria, 82% for late proliferative, 93% for early secretory, 81% for midsecretory, and 60% for late secretory endometria. Diagn Cytopathol 1986;2:198‐20

ISSN:8755-1039    

DOI:10.1002/dc.2840020305

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1986

数据来源: WILEY

摘要:

AbstractAspiration biopsy of four primary endocrine tumors of the pancreas showed single and large sheets of tumor cells. Tumor cells were polygonal in shape with ill‐defined, filmy or granular cytoplasm and regular round nuclei containing a finely granular chromatin pattern and inconspicuous or prominent nucleoli. Focal gland‐like arrangement was seen in several sheets of tumor cells. Aspirate from liver metastases of an endocrine tumor of the pancreas showed single and clustered oval cells with granular cytoplasm and eccentrically located round and hyperchromatic nuclei. Smears prepared from aspirates of three fibrotic pancreata containing nodules of hyperplastic endocrine cells showed smaller fragments of endocrine‐cell epithelium with focal gland‐like arrangement. Individual hyperplastic endocrine cells displayed granular, filmy, and ill‐defined cytoplasm and round to oval hyperchromatic nuclei showing a finely granular chromatin pattern. Nuclear pleomorphism was noted in some cell groups. Diagn Cytopathol 1986;

ISSN:8755-1039    

DOI:10.1002/dc.2840020306

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1986

数据来源: WILEY

摘要:

AbstractSequential tracheal aspirates from 39 neonates with hyaline membrane disease were examined to correlate cytological findings with the development of bronchopulmonary dysplasia (BPD). A total of 224 tracheal aspirates were examined from these infants, 15 of whom developed BPD as diagnosed by conventional clinical and radiological criteria. Hyperplastic and metaplastic epithelial changes were observed in all infants studied. Dysplastic changes occurred in 14 of 15 who developed BPD, and 14 of 24 who had a normal outcome (P<0.02). The exfoliation of dysplastic metaplastic bronchial cells was thus 95% specific and 71% sensitive for the subsequent development of BPD. Factors associated with the development of BPD were very low birth weight and gestational age, persistence of a patent ductus arteriosus, high peak inspiratory pressure (cm of H2O/kg), prolonged assisted ventilation, and rapidity of development of class III (dysplastic) changes in tracheal aspirates. Diagn Cytopathol 1986;2:212‐21

ISSN:8755-1039    

DOI:10.1002/dc.2840020307

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1986

数据来源: WILEY

摘要:

AbstractThe results of neuron‐specific enolase (NSE) and keratin immunodetection in cytological specimens of sputum secured from 41 patients with lung cancer are presented. All 19 cases of small‐cell carcinoma showed intense immunoreactivity for NSE. No such immunoreactivity was found in 21 of 22 cases of non‐small‐cell carcinoma. The single positive result was from a case of large‐cell undifferentiated carcinoma. All 10 cases of squamous‐cell carcinoma showed immunoreactivity for keratin. The 19 cases of small‐cell carcinoma showed no such reactivity. Our findings indicate that immunostaining for NSE and keratin is a valuable aid when a definite diagnosis of small‐cell carcinoma of the lung can not be made on the basis of conventional cytologic features. Diagn Cytopathol

ISSN:8755-1039    

DOI:10.1002/dc.2840020308

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1986

数据来源: WILEY

摘要:

AbstractPercutaneous fine needle aspiration biopsy of the pancreas allows to obtain without surgery a tissue proven diagnosis of focal lesions of the pancreas. Ultrasound (US), computed tomography (CT), or fluoroscopy are used to guide the positioning of the needle in the lesion. Various benign and malignant lesions can be diagnosed and the cytologic features of them are presented. The average sensitivity of the technique in the diagnosis of pancreatic carcinoma is 80.5% in the literature. The use of percutaneous fine needle biopsy of the pancreas decreases the number of investigations to be done in a patient with pancreatic disease. Diagn Cytopathol 1986;2:221‐22

ISSN:8755-1039    

DOI:10.1002/dc.2840020309

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1986

数据来源: WILEY

ISSN:8755-1039    

DOI:10.1002/dc.2840020310

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1986

数据来源: WILEY

ISSN:8755-1039    

DOI:10.1002/dc.2840020311

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1986

数据来源: WILEY