ISSN:8755-1039    

DOI:10.1002/dc.2840110102

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

摘要:

AbstractTwo hundred and forty‐nine women suffering from breast problems underwent a complete series of tests including clinical examination, mammography, echography, thermography, and fine‐needle aspiration (FNA). Ninety‐four of these patients were shown to be positive or to have suspected malignancy. Accordingly, they underwent surgical excision followed by histologic examination, while the remaining patients were re‐examined after 12 to 18 mo in order to exclude false negatives.The analysis of specificity and sensitivity of every single procedure showed that FNA describes the best degree of sensitivity and specificity but no procedure allows, by itself, the detection of all carcinomas. When considered in combination, clinical examination, mammography, and fine‐needle aspiration have a sensitivity of 100% and a specificity of 49%, and are the best diagnostic tests for a correct assessment of mammary lesions. Thermography and echography showed a low degree of sensitivity and should not be included in the routine diagnostic procedure of breast lesions. Diagn Cytopathol 1994; 11:4–8. © 1994 Wil

ISSN:8755-1039    

DOI:10.1002/dc.2840110103

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

摘要:

AbstractA 4‐year study (January 1986 through December 1990) was performed to evaluate the cytomorphologic features of cystic ovarian lesions. Fluid from 103 cases was obtained either during surgical removal of the ovary (48 cases; mean age 50 years) or by fine needle aspiration (55 cases; mean age 32 years). Of the 48 cystic lesions with histologic correlation, 30 (62.5%) were neoplastic and 18 (37.5%) were non‐neoplastic. Ten (18%) of the 55 aspirates were unsatisfactory. The remaining 45 cases (82%) were benign, predominantly non‐neoplastic entities which included follicle, corpora luteal, and endometriotic cysts. Neoplastic cystic lesions included serous, mucinous, and Brenner tumors, germ cell neoplasms, a sex cord‐stromal tumor, and an undifferentiated carcinoma. Follicle and corpora luteal cysts were composed of loose cell clusters of granulosa cells and/or luteinized granulosa cells. Endometriotic cysts contained hemosiderin‐laden macro‐phages and endometrial cells. Serous and mucinous cystadenomas were composed of cohesive sheets and/or papillary clusters of epithelial cells. A cystic Brenner tumor showed sheets of cells with grooved nuclei, and a benign cystic teratoma contained mature squamous cells admixed with vacuolated cells of presumed sebaceous origin. Although the distinction between benign and malignant entities posed few diagnostic difficulties, borderline tumors could not be distinguished from well‐differentiated cystadenocarcinomas. The results of this study indicate that the majority of cystic ovarian lesions can be diagnosed accurately on cytology. Cytologic evaluation of non‐neoplastic ovarian cysts is important for women who want to retain their fertility and in the clinical management of women with neoplastic lesions. Diagn Cytopathol 1994; 11:9–14. © 19

ISSN:8755-1039    

DOI:10.1002/dc.2840110104

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

摘要:

AbstractWith the increased use of screening mammography, many occult lesions are being identified. Despite the availability of ultrasonography and stereotaxis, their use in conjunction with fine‐needle aspiration biopsy for further examination of these lesions, at the time when cost containment is a serious consideration, must be evaluated. Consequently, the role of cytopathologist becomes important in identifying lesions requiring timely follow‐up and surgical treatment.To assist the clinicians in evaluating the best approach to occult lesions, we reviewed the results from ultrasonographic guided aspiration biopsies (100) and stereotactic guided aspiration biopsies (61) at our institution. Our findings and review of the literature suggest that the former should only be used sparingly. By contrast, stereotactic biopsies interpreted as a part of an interdisciplinary approach can provide critical information for decision‐making. Diagn Cytopathol 1994; 11:15–19. © 1994 Wiley

ISSN:8755-1039    

DOI:10.1002/dc.2840110105

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

摘要:

AbstractTo evaluate the accuracy of a Chlamydia diagnosis in our laboratory, cytologic Chlamydia diagnoses for the years 1990 and 1991 were compared with immunofluorescent studies for Chlamydia for the same period. Only one of 22 cases diagnosed cytologically as suggestive of Chlamydia had a positive immunofluorescent result. On rescreen of 110 cervicovaginal smears taken within I mo of a positive fluorescent antibody test, 11 cases were found to contain criteria suggestive of Chlamydia. These correlations represent a 4.5% specificity and 10% sensitivity rate, suggesting that our current efforts in cytology are not effective in determining the presence ofChlamydia. Diagn Cytopathol 1994; 11:20–22. © 1994 Wiley‐Liss,

ISSN:8755-1039    

DOI:10.1002/dc.2840110106

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

摘要:

AbstractLymphoglandular bodies (cytoplasmic fragments) were counted in 10 high power fields (HPF) of the smears in 35 cases of non‐Hodgkin lymphoma (NHL), 26 Hodgkin's disease (HD), 36 reactive lymphadenitis, 24 non‐lymphoid round cell tumors, and 20 cases of secondaries in lymph nodes. The number of lymphoglandular bodies in both May‐Grünwald‐Giemsa (MGG) and hematox‐ylin‐eosin (H&E) stained smears in NHL, HD, and reactive lymphadenitis were significantly higher compared to non‐lymphoid round cell tumors (P100 lymphoglandular bodies per 10 HPF. On the other hand only 4.8% of non‐lymphoid round cell tumors crossed this level in both H&E stained and MGG stained smears. Number of lymphoglandular bodies was also significantly higher in MGG stained smears compared to H&E stained smears (P<0.05 to<0.01) and in fine‐needle aspiration (FNA) smears compared to imprint smears (P<0.01 to<0.001) in cases of NHL, HD, and reactive lymphadenitis. Diagn Cytopathol 1994; 11:23–27. ©

ISSN:8755-1039    

DOI:10.1002/dc.2840110107

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

摘要:

AbstractPapanicolaou (Pap)‐stained cervical specimens from 160 squamous lesions were processed for the detection of human papillomavirus (HPV) DNA by an in situ hybridization (ISH) assay. Three biotinylated HPV DNA probes were employed, each containing HPV genotypes 6/11, HPV genotypes 16/18, or HPV genotypes 31/35/51. The HPV etiology of 86 lesions was ascertained (53.8%). In 74 out of 135 (58.8%) HPV‐typed low‐grade squamous intraepithelial lesions (SILs), HPV 6/11 was found in nine (6.6%), HPV 16/18 in 46 (34.2%), and HPV31/35/51 in 19 lesions (14.1%); in 11 out of 18 HPV‐typed high‐grade SILs (61.1%), seven lesions (38.9%) were typed for HPV 16/18 and four (22.2%) for HPV 31/35/51. Of seven invasive carcinomas, only one (14.3%) reacted with the HPV 16/18 DNA probe. A cohort of 124 low‐grade SILs was followed cytologically for a year. The results of this study are discussed in light of HPV type association and therapy. Diagn Cytopathol 1994; 11:28–32. © 1994 W

ISSN:8755-1039    

DOI:10.1002/dc.2840110108

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

摘要:

AbstractThe diagnoses of 1,000 pairs of conventional Papanicolaou (Pap) smears and ThinPrep® preparations were compared. Cervical cells were collected using an Ayre spatula and endocervical brush. The conventional smear was made first, the collection devices were rinsed into PreservCyt® solution, and the slides were prepared using the ThinPrep® Processor. The diagnoses of the paired smears agreed in 988 of the 1,000 cases (98.8%), including 949 negatives, 28 atypicals, 9 low grade squamous intraepithelial lesions (LGSIL), and 2 high grade squamous intraepithelial lesions (HGSIL). Five cases where LGSIL or HGSIL was found on the ThinPrep® slide were negative or atypical on the conventional smear. No conventional smear abnormalities were missed on the ThinPrep® slide. Although not statistically significant, this difference indicates that the ThinPrep® method gives a better diagnosis of abnormalities than the conventional method. The ThinPrep® method was acceptable to participating physicians and ThinPreps® were easier and faster to screen than conventional smears. Diagn Cytopathol 1994; 11:33–37. © 1994 Wiley

ISSN:8755-1039    

DOI:10.1002/dc.2840110109

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

摘要:

AbstractCrystals consisting by light microscopy of organic matrix (matrix crystals) encountered in cytologic urine specimens of 8 patients were examined for mineral phase components by scanning electron microscopy with energy dispersive X‐ray microanalysis (SEM‐EDX) and by morphologic scanning electron microscopy (SEM) performed separately in four of the eight cases. Whenever possible (three cases) mineralized crystals present in these specimens were examined separately by SEM‐EDX for comparison of mineral phase composition with that of the corresponding matrix forms. Although by SEM‐EDX components of matrix, glass and slide preparation media interfere with the precise estimation of the mineral phase components, the results of this method supported by the SEM morphology suggest that crystals consisting of organic matrix include a mineral phase, the lattice structure of which provides them from the early stages of formation with the characteristic morphology of the fully mineralized forms. This also suggests that organic matrix plays a role in the nucleation of minerals during the formation of certain urinary crystals. Diagn Cytopathol 1994; 11:38–46. © 1994 Wiley

ISSN:8755-1039    

DOI:10.1002/dc.2840110110

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY

摘要:

AbstractSalivary duct carcinoma (SDC) is an extremely rare and highly aggressive primary epithelial neoplasm of the salivary glands associated with increased tendency for lymph node and vascular metastases. Histologically, this lesion resembles intraductal cribri‐form and comedo carcinoma of the breast. Fine‐needle aspiration (FNA) cytology of SDC in two patients with parotid masses (ages 65 and 67) is presented. The aspirates were sparsely to richly cellular and contained predominantly broad flat and branching sheets of large polygonal epithelial cells with abundant eosinophilic cytoplasm, round to oval nuclei, finely granular chromatin and prominent nucleoli. Few sheets showed cribriforming and papillary configuration. The cytologic differential diagnosis included oncocytoma, acinic cell carcinoma, muco‐epidermoid carcinoma, and melastatic adenocarcinoma. To the best of our knowledge, this is the first report to describe a spectrum of cytologic features that may allow a specific FNA diagnosis of SDC. Preoperative diagnosis of this neoplasm may warrant a more extensive radiologic workup and therapy including radical surgery and neck dissection followed by radiation therapy. Diagn Cytopathol 1994; 11:47–51. © 1994 Wiley

ISSN:8755-1039    

DOI:10.1002/dc.2840110111

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1994

数据来源: WILEY