摘要:

AbstractThe lymphocyte populations and subpopulations extracted from inflamed periodontal tissues of patients with adult periodontitis were determined. 34 patients were grouped according to the gingival index score (GI) of 1, 2 and 3. Gingival tissue from 2 involved teeth was excised, treated with collagenase, and infiltrating cells were isolated and identified using monoclonal antibodies for lymphocyte sets and subsets. The % of CD3+ cells was about 54.5% in all 3 patient groups, but the percentage of CD22+cells increased from 28.9 ± 3.3% in the group with GI = 1 to 33 ± 1.2% in the group with GI = 3. %s of CD4+ cells and activated CD4+ cells increased from 30.2 + 2,1% and 4.1 ±1.1% in the group with GI= 1 to 38.4±1.2% and 16.0 ± 3.4% in the group with GI = 3, respectively, while in the same groups, the % of CD8+cells decreased from 24.9 ± 2.0% to 17.7 ± 1.6%. These data indicate a possible importance of activated CD4+cells in pathogenetic mechanisms of periodo

ISSN:0303-6979    

DOI:10.1111/j.1600-051X.1992.tb00631.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractThe aim of the investigation was to evaluate the potential for new attachment formation at various degree III furcation involvements in the beagle dog. 3 differently shaped furcation defects were prepared; one small and one large key‐hole defect, and one furcation defect which was part of “circumferential” loss of attachment and bone. 15 beagle dogs were used in the experiments. The furcation defects were surgically created at mandibular premolars in the right and left side of the jaw. Test teeth were subsequently treated according to the GTR principle, while control teeth were treated without the application of membranes. The result from the histological examination of biopsy specimens revealed that GTR treatment may result in complete new attachment at surgically produced “through and through” furcation involvements in dogs. The study, however, also revealed that the size of the furcation defect as well as the shape of the surrounding alveolar bone were factors that determined the outcome of this kind of treatment. The treatment failures were consistently associated with flap recession during healing which resulted in the exposure of the furcati

ISSN:0303-6979    

DOI:10.1111/j.1600-051X.1992.tb00632.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractThe use of systemic tetracycline in the treatment of periodontal disease has been controversial. To investigate this controversy, we performed a quality assessment and attempted to perform a meta‐analysis of 13 published studies. We evaluated the quality of the study protocol and data analysis and presentation for each study. We were unable to combine data from the majority of studies due to heterogeneity of the outcomes evaluated and limitations in data reported in the individual studies. Therefore, only 2 studies were included in the quantitative meta‐analysis. On a scale of 0–1, the mean score for this group of studies was 0.27 (±0.19) for study protocol and 0.31 (±0.11) for data analysis and presentation. Mean reduction in probing depth for the group treated with tetracycline plus scaling was 2.45 mm; for the group which received only scaling, 2.02 mm; for the group that received only tetracycline, 3.98 mm; and for the control group, 0.65 mm. We conclude that analysis of data from the published literature does not demonstrate that the use of systemic tetracycline is more beneficial than conventional treatment in the management of adult periodontal disease. More information is needed in order to perform an extensive meta‐analysis of thi

ISSN:0303-6979    

DOI:10.1111/j.1600-051X.1992.tb00633.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractThe purpose of the study was to evaluate the effect of a mouthrinse regimen comprising both chemical plaque control and mechanical plaque removal. 20 adult patients with acute myeloid leukaemia were assigned to one of the following 2 regimens: (1) (group 1) mouthrinse twice daily with a 0.1% chlorhexidine solution; or (2) (group 2) the same regimen, but preceded by mechanical removal of plaque and calculus on day 1. All patients were followed for 28 days from the initiation of remission‐induction therapy. In group 2, the plaque scores remained lower than those of group 1 throughout the study, although only 3 patients remained completely free of plaque after 28 days. Gingival inflammation as judged by bleeding scores remained unchanged in group 1, whereas in group 2, the degree of inflammation was reduced from 52% (median value) on day 1 to 31% (median value) on day 28. The bleeding scores were also lower in group 2 (31%) than in group 1 (60%) on day 28. No differences were found between the 2 groups with respect to the occurrence of other oral infections. It is concluded that chemical plaque control with chlorhexidine should be preceded by mechanical removal of plaque and calculus, when used in patients with acute myeloid leukaemia and thrombocytopeni

ISSN:0303-6979    

DOI:10.1111/j.1600-051X.1992.tb00634.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractThe aim of this study was to assess the prevalence and severity of periodontal destruction in regular dental attenders in Northern Ireland. 132 individuals aged between 20 and 49 years who had recently had a course of routine treatment in the General Dental Service completed a questionnaire and had a periodontal examination. Measurements of plaque, subgingival calculus, bleeding, probing pocket depth and periodontal attachment level were made at 4 proximal sites per tooth. Plaque was present at an average of 17%, subgingival calculus at 13%, and bleeding on probing at 34% of interproximal surfaces examined. The mean probing pocket depth was 2.7 mm and the mean probing attachment level was 1.0 mm. Incipient periodontal destruction was common with all subjects having at least 1 pocket of ≥ 3 mm and 90% having at least 1 site with ≥ 2 mm attachment loss. Only 24 (18%) of those examined had deep pocketing or severe loss of periodontal attachment (≥ 6 mm). The extent of deep pocketing and severe attachment loss was low at only 0.2% and 0.6%, respectively, of the sites examined. It was concluded that gingivitis and incipient periodontitis were prevalent and extensive in the regular dental attenders investigated, but that severe periodontal destruction was unc

ISSN:0303-6979    

DOI:10.1111/j.1600-051X.1992.tb00635.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractLong‐term high‐dose glucocorticosteroid treatment may be suspected as causing profound marginal periodontal bone loss due to the immunosuppressive/antiinflammatory effects and due to the osteoporotic side‐effects. This study comprised an analysis of the loss of the mandibular and forearm bone mineral content (BMC), measured in vivo by dual‐photon scanner, in relation to the concomitant changes of the periodontal indices (visible plaque, gingival bleeding, loss of attachment) in 17 acute nephrotic dentate patients undergoing intensive steroid treatment for 12 months. The measurements were performed at start of treatment, when all patients were considered healthy as regards the skeleton, and at the 6‐month and 12‐month follow‐up. The mean BMC loss at the standard sites of the mandible and the forearm bones was 5.6%/year at both sites. No significant changes could be demonstrated in the periodontal indices (P>0.10), and no relation was found between the mandibular BMC loss and the periodontal condition (R = 0.06,P>0.10). In conclusion, profound marginal periodontal bone loss does not seem to be a prominent side‐effect of long‐term glucocorticosteroid treatment, although the degree of induced osteopenia in the mandible corresponds to that in other cortical bone

ISSN:0303-6979    

DOI:10.1111/j.1600-051X.1992.tb00636.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractElastase‐a1 proteinase inhibitor (Ea1PI) concentrations were assessed in gingival crevicular fluids and evaluated in relation to the clinical signs of periodontal disease. 7 gingivitis patients (group G), 38 patients with adult periodontitis and clinically stable lesions (group AP), 21 patients with rapidly progressive periodontitis and clinically stable lesions (group RPP) and 11 patients with either adult periodontitis or rapidly progressive periodontitis and clinically progressive lesions (group Pr) were studied. 6 healthy subjects served as the control group (group H). Significant differences were observed in the Ea1PI concentration between the healthy, gingivitis, clinically stable periodontitis and clinically progressive periodontitis group. In the control group, no Ea1PI was detected. Groups G, AP and RPP showed mean Ea1PI concentrations of 10.95 ± 4.96 μg/ ml. 35.55 ± 18.64 /μg/ml and 38.56 ± 20.89 μg/ml, respectively. In these groups, high enzyme levels were correlated with clinical signs of inflammation. The highest Ea1PI levels were observed in the clinically progressive lesions. However, they were not necessarily associated with bleeding on probing or clinical evidence of inflammation. These data suggest that a significant increase in crevicular Ea1PI levels may be an early manifestation of a progressive or potentially progressive periodontal

ISSN:0303-6979    

DOI:10.1111/j.1600-051X.1992.tb00637.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractThe purpose of the present study was to estimate the lost attachment surface area (LAS) and the remaining attachment surface area (RAS) of molars from a combination of clinical and radiographic measurements. Clinical and radiographic measurements on 32 maxillary and 26 mandibular molars were correlated with the post‐extraction measurements of LAS and RAS. The results indicate that linear models may increase the precision of the estimate of LAS by a factor of 1.2 for maxillary molars and 1.4 for mandibular molars when compared to estimates of LAS using only attachment level measurements. A diagnostic model for RAS predicts the square root of the remaining attachment surface area with the information obtained from the remaining radiographic attachment area and a gingivitis index. It is concluded that modeling of periodontal data may provide a method for predicting lost and remaining periodontal attachment area of molar teet

ISSN:0303-6979    

DOI:10.1111/j.1600-051X.1992.tb00638.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Abstract2 strontium chloride hexahydrate‐containing dentifrices (SCH), similar except for their respective abrasive systems, were compared in a 2–month randomised double‐blind parallel clinical study to evaluate their comparative effectiveness in terms of cervical dentinal hypersensitivity. 2 groups of 20 subjects, each with cervical dentinal hypersensitivity, were evaluated for tactile sensitivity by Yeaple probe, air sensitivity using a dental air syringe and subjective perception of pain by means of a visual analogue scale. There was no difference between the dentifrices as regards reduction of cervical dentinal hypersensitivity at each time point. The response to both dentifrices was evident within 4 weeks of use and the degree of improvement increased throughout the 8–week study period. The results support the conclusion that changing the abrasive component of SCH dentifrices did not significantly increase or decrease the (desensitizing) activity of the original

ISSN:0303-6979    

DOI:10.1111/j.1600-051X.1992.tb00639.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractThe anti‐plaque, anti‐gingivitis and anti‐microbial efficacies of a phenolic compound (Listerine®) and 2 different amine/stannous fluoride mouthwashes (Meridol1® I, II) were compared when these solutions were used in addition to usual toothcleaning. A placebo preparation was utilized as a negative control and a chlorhexidine solution as a positive control in this double‐blind study. After professional toothcleaning, 49 volunteers continued their habitual, self‐performed and non‐supervised oral hygiene for a period of 2 weeks, in order to have a more standard baseline. At day 0, they began to rinse twice daily with 1 of the 5 mouthwashes. After 3 weeks of rinsing, plaque indices remained the lowest in the chlorhexidine and the Meridol® 1 groups, while subjects using Listerine® or Merido® II demonstrated similar indices significantly lower than that of individuals rinsing with the placebo solution. Through this period, the gingival index scores were similar in the Meridol®, Listerine® and chlorhexidine groups. At day 21, the mean GI scores in the chlorhexidine group were significantly lower than the scores in the placebo group. The plaque vitality scores showed a bacteria] effect in vivo of chlorhexidine and, to a lesser extent, of the Meridol® solutions. No substantial evidence of an antibacterial effect in vivo was found for Listerine®. This study has demonstrated that when mouthrinses are used to supplement habitual mechanical oral hygiene, chlorhexidine remains the most powerful solution. Furthermore, it was also shown that a combination of habitual self‐performed and non‐supervised oral hygiene with Meridol® or Listerine® is more beneficial for plaque control than the use of mec

ISSN:0303-6979    

DOI:10.1111/j.1600-051X.1992.tb00640.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY