ISSN:0148-7043    

出版商:OVID    

年代:1985

数据来源: OVID

ISSN:0148-7043    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

The mechanism by which open wounds contract is unknown. Although myofibroblasts are implicated in this natural process of wound healing, the evidence, however convincing, is only circumstantial. Control of wound contraction has been sought for many years, but only the application of full-thickness skin grafts is able to produce safe and effective clinical results. By comparing the synthetic skin substitute Biobrane and its component parts with full-thickness skin grafts in a rat wound model, we have demonstrated that dermis is not required for inhibition of wound contraction. We postulate that physical properties of skin and its synthetic analogues, including adherence to the wound surface, may be the signals to the open wound that effectively inhibit contraction. Whether myofibroblasts participate in this interaction remains unanswered.

ISSN:0148-7043    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

From both human and animal tissues, myofibroblasts can be successfully cultured in vitro through multiple passages. As compared with cultured fibroblasts from control tissues, early passage myofibroblasts have slower growth cycles, as is typical of highly differentiated cells. Also in early passage, differences between myofibroblasts and fibroblasts in tissue culture in vivo can be preserved. Late passage animal studies suggest dedifferentiation in both morphology and growth cycle rate. As indicated by our data, which have been discussed in detail in our previous investigations, we believe that further studies may help to define how such dedifferentiation occurs and may determine ways to do so clinically. However, such control attempts must take into account the heterogeneity of myofibroblast and fibroblast populations which these studies have identified.

ISSN:0148-7043    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Many people are burned each year and subsequently develop hypertrophic burn scars. An objective means for quantitatively measuring scar characteristics would be useful in monitoring resolution of the individual patient's scars as well as in evaluating different treatment protocols. Two methods for quantitative measurement of hypertrophic scars were evaluated in 4 patients at 8 scar sites over a 2-month period. A specially designed tonometer, the cicatrometer, assesses scar firmness and pliability. It is shown to provide a simple noninvasive means for objectively evaluating the progress of scar maturation and therapy. High-resolution ultrasonic scanning is shown to provide an objective, quantitative measurement of hypertrophic scar thickness, which can be compared between patients. This allows for the design of controlled trials comparing different treatment protocols.

ISSN:0148-7043    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Disfigurement after oromandibular cancer surgery is as much feared as the tumor itself. A deviated jaw, collapsed neck, and muffled speech are external markers that may prevent normal life. Yet such stigmata are not necessary. For two years we have used an immediate reconstruction that avoids these problems. In 12 patients we used a pectoralis musculocutaneous flap plus a stainless steel shaped bridging bone plate placed under or through the flap. The flap reconstructs the floor of the mouth, while the bridging bone plate preserves mandibular continuity. A McFee incision avoids vertical scarring, and the muscle pedicle duplicates the missing neck contents. Meticulous lip closure completes the procedure, which often does not necessitate tracheotomy scarring.Our patients have maintained a highly satisfactory appearance of face and jaw, with normal swallowing and clear speech. In treatment of oromandibular cancer, aesthetic considerations are essential.

ISSN:0148-7043    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Surgeons are accustomed to categorizing the birth defects they treat surgically according to morphology rather than pathogenesis. Commonly used classification systems fail to take into account the cause or developmental pathology of a given structural defect. Furthermore, surgeons often select operative procedures without considering the evolution of specific defects.Dysmorphology is a fairly new discipline that seeks a better understanding of the cause and pathogenesis of birth defects, not only to ensure optimum treatment but also to encourage prevention of birth defects.

ISSN:0148-7043    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Dentists are aware of the extraordinary influence an active thrusting tongue can have on dental development. In the presence of the profound muscle hypertrophy characteristic of macroglossia in the Beckwith-Wiedemann syndrome, a compelling need exists for surgical reduction of the tongue as early in life as possible. This report describes our clinical experience with 3 children, 1 referred late and the other 2 treated within the first year of life.

ISSN:0148-7043    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Plastic surgeons are likely to see patients who have successfully completed alcohol or drug abusers' rehabilitation programs. These patients are seeking to improve their appearance and, hence, their self-image. Unless special care is given to the recovering alcoholic, he or she is at risk of readdiction to alcohol or to drugs after surgery. Recommendations are made regarding the timing of elective operations, the use of drugs during and after the procedure, and reliance on a dependable third party to dispense drugs postoperatively.

ISSN:0148-7043    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

An operation is described for the correction of the unilateral cleft lip nose when there is a deficiency of alar tissue with superior displacement of the alar maxillary junction. This method uses a full-thickness graft from the contralateral alar crease.

ISSN:0148-7043    

出版商:OVID    

年代:1985

数据来源: OVID