摘要:

A simple, accurate and specific proton magnetic resonance (PMR) procedure was developed for the assay of azintamide and its tablets. The method involves comparing the integral of both the multiplet centered at 1.15 ppm and the sharp nice singlet signal at 4.3 ppm of azintamide molecule to that of the sharp singlet signal (positioned at 6.3 ppm) of maleic acid which is used as internal standard. The method reported in this study gives accurate and reproducible results; 99.96 × 0.54% (using integral values of methyl protons) and 100.10 × 0.43% (using integral value of methylene protons) for authentic azintamide, while it gives 100.15 × 0.39Z for azintamide tablets (Suragallin). In addition, the PMR spectrum obtained helps in confirming the identity and purity of the drug.

ISSN:0003-2719    

DOI:10.1080/00032718708064595

出版商:Taylor & Francis Group    

年代:1987

数据来源: Taylor

摘要:

A simple and sensitive method has been developed for the determination of disopyramide employing reverse phase high performance liquid chromatography with UV detection. p-Chlorodisopyramide was used as an internal standard. The retention times of disopyramide and the internal standard at an elution rate of 1.8 ml/min were 6.28 and 8.78 min, respectively.

ISSN:0003-2719    

DOI:10.1080/00032718708064596

出版商:Taylor & Francis Group    

年代:1987

数据来源: Taylor

摘要:

This is a scanned image of the original Editorial Board page(s) for this issue.

ISSN:0003-2719    

DOI:10.1080/00032718708064584

出版商:Taylor & Francis Group    

年代:1987

数据来源: Taylor