摘要:

An isotachophoretic histamine assay has been developed to determine the histamine content in hymenoptera stinging insect venoms. The amount of histamine was lowest in bee venom (0.9%) while the histamine content of vespid venom extracts varied between 2.7–5.2%. Histamine, determined quantitatively by isotachophoresis, correlated well with the histamine values achieved with reversed-phase high performance liquid chromatography.

ISSN:0003-2719    

DOI:10.1080/00032718208069526

出版商:Taylor & Francis Group    

年代:1982

数据来源: Taylor

摘要:

Seven analogs of DL-thyroxine (1) were synthesized and evaluated as internal standards for the reversed-phase HPLC analysis of thyroidal amino acids. On the basis of retention time, separation from DL-thyroxine (1), stability, solubility and ease of preparation, 3-[3-(4′-hydroxy-3′,5′-diiodophenoxy)-2,4,6-triiodophenyl)]-DL-alanine (4) appeared to be the best candidate for use as an internal standard.

ISSN:0003-2719    

DOI:10.1080/00032718208069527

出版商:Taylor & Francis Group    

年代:1982

数据来源: Taylor

摘要:

New methods of analysis were developed for the determination of volatile compounds (alcohols, ketones, aldehydes etc.), barbiturates, neutral drugs, anticonvulsant drugs, cardiac glycosides, benzodiazepines, CNS-stimulants, theophylline and quinidine.

ISSN:0003-2719    

DOI:10.1080/00032718208069528

出版商:Taylor & Francis Group    

年代:1982

数据来源: Taylor

摘要:

A reverse phase high performance liquid chromatographic (HPLC) assay is used to quantitate N1-acetyl sulfisoxazole and the related manufacturing impurities sulfisoxazole, N4-acetyl sulfisoxazole and N1,N4-diacetyl sulfisoxazole. The HPLC separations are achieved using a microparticulate octadecylsilane column with a ternary aqueous acetic acid: acetonitrile: methanol mobile phase. The HPLC analysis of the drug potency is specific, precise (RSD values 0.3 to 1.5%) and agrees with USP XX sodium nitrite titration assays. The HPLC assay of the related manufacturing impurities requires less than 12 min. per injection and has precision (RSD values) ranging from 1.1 to 36.2%. The manufacturing impurities are detectable to less than 0.1% using the HPLC procedure. A thin layer chromatographic (TLC) procedure is described to compliment the HPLC quantitation of the manufacturing impurities.

ISSN:0003-2719    

DOI:10.1080/00032718208069529

出版商:Taylor & Francis Group    

年代:1982

数据来源: Taylor

ISSN:0003-2719    

DOI:10.1080/00032718208069530

出版商:Taylor & Francis Group    

年代:1982

数据来源: Taylor

摘要:

Spectrophotometric, coloriaetric and differential pulse polarographic “DPP” techniques were adopted for microdetermination of methotrexate in pure form and in pharmaceutical preparations. The spectrophotometric method was based on measuring the light absorbance at 303 nm in 0.1 N NaCH. The colorimetric method was based on coupling the diazotised methotrexate with 8-hydroxy quinoline in alkaline medium and measuring the colour developed at 430 nm. The three proposed techniques were compared with the E.P. 1980. method. The DPP method was further used for methotrexste determination in presence of some biological fluids.

ISSN:0003-2719    

DOI:10.1080/00032718208069531

出版商:Taylor & Francis Group    

年代:1982

数据来源: Taylor

摘要:

This is a scanned image of the original Editorial Board page(s) for this issue.

ISSN:0003-2719    

DOI:10.1080/00032718208069525

出版商:Taylor & Francis Group    

年代:1982

数据来源: Taylor