摘要:

Discontinuation of alprazolam after long-term treatment of 142 patients with panic-related disorders was examined in five study sites using a telephone interview. The majority (67%) of patients interviewed discontinued alprazolam for a period of at least 3 days after a gradual dosage reduction schedule over a 4-week period at the end of the long-term treatment study. A marked difference among the study sites in percentages of patients discontinuing therapy with alprazolam suggests that physician intervention played an important role in determining the ability of patients successfully to discontinue use of alprazolam: 90% and 95% of patients ceased therapy at two sites whereas only 21%, 38%, and 66% of patients discontinued therapy at the other three sites. The mean daily dosage for patients who continued using alprazolam decreased from 5.1 mg/day at the end of the long-term segment to 2.7 mg/day at the time of the poststudy interview. This decline indicates a lack of tolerance to the therapeutic effectiveness of alprazolam over an extended period of time.

ISSN:0271-0749    

出版商:OVID    

年代:1992

数据来源: OVID

摘要:

Four patients treated with fluoxetine alone developed generalized urticaria. One also suffered polyarthritis. These reactions subsided when fluoxetine was stopped. After 6–12 months, because of progressive psychiatric problems, fluoxetine was reintroduced using a desensitization protocol. In each case this was well tolerated, and fluoxetine has been continued without adverse affects for 3–10 months.

ISSN:0271-0749    

出版商:OVID    

年代:1992

数据来源: OVID

ISSN:0271-0749    

出版商:OVID    

年代:1992

数据来源: OVID

摘要:

I recently saw a patient suffering from manic depression who said she had “pseudo something or other” that had been caused by her lithium treatment. She was unable to be more specific and unwilling to give me the name of her doctor. She said she never wanted to be treated by drugs again and wanted cognitive psychotherapy. I read a recent letter in your journal that mentions lithium as a treatment for pseudobul-bar affect.1Does lithium both cause and treat this? I am also confused because she says her problems at the time were depression, nausea, and headaches and not the pathologic laughter described in the article. She did try to joke about some of her current distress, but this seemed clearly defensive and under her control. She also described a single prior manic episode in which she was overactive, unable to sleep, elated, and silly.

ISSN:0271-0749    

出版商:OVID    

年代:1992

数据来源: OVID

ISSN:0271-0749    

出版商:OVID    

年代:1992

数据来源: OVID

ISSN:0271-0749    

出版商:OVID    

年代:1992

数据来源: OVID

ISSN:0271-0749    

出版商:OVID    

年代:1992

数据来源: OVID

ISSN:0271-0749    

出版商:OVID    

年代:1992

数据来源: OVID

ISSN:0271-0749    

出版商:OVID    

年代:1992

数据来源: OVID

ISSN:0271-0749    

出版商:OVID    

年代:1992

数据来源: OVID