ISSN:0271-0749    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

&NA;Eighty‐six patients with acute psychotic exacerbations were treated with fixed dosage regimens of oral fluphenazine up to 10‐30 mg/day in randomized, double‐blind studies. Dystonic reactions occurred in 33.8% of the subjects at risk. Of these, 58% occurred by the third day, 88% by the fourth day, and 100% by the ninth day of treatment; most occurred later in the interdose interval. Significant predictors of dystonic reactions were higher fluphenazine mg/kg dosage and younger age. There was a trend toward a lower risk of dystonia in patients who received amobarbital sodium for agitation. Results are discussed in relation to possible mechanisms of neuroleptic‐induced dystonia.(J Clin Psychopharmacol 1990;10:389‐396)

ISSN:0271-0749    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

&NA;Twenty‐five inpatients with acute exacerbations of schizophrenia (by Research Diagnostic Criteria) or schizoaffective disorder underwent a prospective haloperidol dosing procedure and were assigned fixed doses chosen to yield a distribution of haloperidol plasma levels above and below a hypothesized upper therapeutic limit of 18 ng/ml. Changes in Brief Psychiatric Rating Scale scores after 1 week of treatment were negatively correlated with haloperidol plasma levels, and the statistically optimum cutoff point fell near the predicted 18 ng/ml. Plasma level/response relationships over the subsequent 3 weeks were weaker but patients with higher plasma levels had consistently less improvement.(J Clin Psychopharmacol 1990;10:397‐402)

ISSN:0271-0749    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

&NA;A double‐blind comparison of clonazepam and lorazepam was conducted in 24 patients with acute mania. Patients received either clonazepam or lorazepam alone for 14 days. Treatment with lorazepam produced marked improvement in symptomatology, while treatment with clonazepam failed to demonstrate a significant therapeutic effect. Sixty‐one percent of patients responded to treatment with lorazepam, with 38.5% achieving remission. This compares to an 18.2% response rate and 0% remission rate in patients treated with clonazepam. These findings support the usefulness of lorazepam in the treatment of acute mania.(J Clin Psychopharmacol 1990;10:403‐408)

ISSN:0271-0749    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

&NA;In this review, the physiologic and pharmacologic effects of tricyclic antidepressants are discussed as they apply to an overdose situation. Systemic arterial hypotension is a frequent occurrence in major overdoses. Occasionally conventional resuscitative measures such as crystalloid or colloid infusion are inadequate and vasoactive agents must be employed in an attempt to normalize blood pressure. The use of these agents is discussed in terms of their physiologic and pharmacologic actions in the management of refractory hypotension induced by tricyclics.(J Clin Psychopharmacol 1990;10:409‐413)

ISSN:0271-0749    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

&NA;There have been several case reports of improvement in tardive dyskinesia (TD) after treatment with calcium‐blocking agents. We have conducted prior single‐blind (rater‐blind) studies of verapamil and diltiazem and found a statistically significant improvement in TD with verapamil, and a small improvement that did not reach statistical improvement after diltiazem treatment. We now report a single‐blind (rater‐blind) study of a third calcium antagonist, nifedipine, in the treatment of TD. Nifedipine (30‐60 mg/day) was administered to eight schizophrenic patients with TD. Mean AIMS scores on items 1‐7 decreased from 12.9 ± 2.0 (SD) at baseline to 10.8 ± 2.7 after treament (t= 3.66,p= 0.01). All subjects were able to tolerate the maximal dose of nifedipine without significant side effects. TD is known to be affected by drugs that affect dopamine neurotransmission. Several lines of pre‐clinical and clinical evidence suggest interactions between the calcium antagonists and the CNS dopamine system and provide a possible explanation for the effects on TD seen with calcium antagonists.(J Clin Psychopharmacol 1990;10:414‐416)

ISSN:0271-0749    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

&NA;Fluphenazine decanoate is commonly used as part of maintenance treatment of schizophrenia, but its pharmacokinetics are poorly understood. We administered a single intramuscular dose of fluphenazine decanoate to nine patients and found that plasma fluphenazine level did not decline to 50% of the peak level by day 26 in any of the patients. This means that it has a long half‐life measurable in months rather than weeks.(J Clin Psychopharmacol 1990;10:417‐421)

ISSN:0271-0749    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

&NA;Ten low‐weight (mean, 87.8% of ideal), chronic bulimic patients, seven of whom were previously unsuccessfully treated with antidepressant drugs, received fluoxetine 80 mg/day for 3 months. Endpoint analysis showed a significant decrease in bulimic episodes (p= 0.01), vomiting frequency (p< 0.05), and depression scores (Hamilton Rating Scale for Depression,p< 0.04; Beck Depression Inventory,p= 0.05; Hopkins Symptom Checklist‐90 depression subscale,p< 0.05). In addition, trait anxiety (State‐Trait Anxiety Inventory trait:p< 0.002), obsessive symptoms (Leyton Obsessional Inventory symptom:p= 0.01; Symptom Checklist‐90 obsessive‐compulsive disorders subscale:p= 0.02), and traits (Leyton Obsessional Inventory trait:p= 0.005) also decreased significantly. There was no change in state anxiety or in Leyton Obsessional Inventory interference and resistance scores. There was no significant increase in weight. Two patients were in remission, two were much improved, two improved, and four showed no change. Side effects were minimal. There were no dropouts.(J Clin Psychopharmacol 1990;10:421‐425)

ISSN:0271-0749    

出版商:OVID    

年代:1990

数据来源: OVID

ISSN:0271-0749    

出版商:OVID    

年代:1990

数据来源: OVID

ISSN:0271-0749    

出版商:OVID    

年代:1990

数据来源: OVID