ISSN:0271-0749    

出版商:OVID    

年代:1981

数据来源: OVID

摘要:

&NA;As a test of the hypothesis that neuroleptics can induce a psychosis secondary to dopamine receptor supersensitivity, we examined the behavioral ratings of 20 symptomatic chronic schizophrenic patients who were withdrawn from neuroleptic drugs and maintained drug free for 4 wk. We hypothesized that, if supersensitivity existed, it might be reflected in a drug‐free course characterized by an initial phase of exacerbation followed by improvement (a “hump”). Four patients had such a course. No patient had the inverse of this hypothesized course (improvement followed by relapse). The implications of this finding and problems inherent in testing the supersensitivity psychosis hypothesis are discussed.

ISSN:0271-0749    

出版商:OVID    

年代:1981

数据来源: OVID

摘要:

&NA;Lithium interactions with other drugs are summarized from human and animal studies filed at the Lithium Information Center.

ISSN:0271-0749    

出版商:OVID    

年代:1981

数据来源: OVID

摘要:

&NA;The cytogenetic effects of subacute oral administration of &Dgr;‐9‐tetrahydrocannabinol, cannabidiol, cannabinol, and placebo were assessed in 27 subjects in a prospective double‐blind study. Both conventional chromosome aberration analysis and sister chromatid exchange were considered. A comparison group of 5 nondrug users was also investigated. The aneuploidy frequency decreased significantly following &Dgr;‐9‐tetrahydrocannabinol administration. By contrast, the frequencies of chromosome aberrations increased slightly for all three drug groups and decreased in the placebo and comparison groups although none of the predrug versus postdrug comparisons were statistically significant. No increase in the sister chromatid exchange frequency was found in any of the groups when predrug versus postdrug comparisons were made. The present study is the fourth short term prospective investigation failing to demonstrate a statistically significant increase in chromosome damage due to cannabinoid usage. However, it must be kept in mind that to date only gross chromosomal aberrations have been identified so that the more subtle chromosomal as well as molecular genetic damage has not been ruled out.

ISSN:0271-0749    

出版商:OVID    

年代:1981

数据来源: OVID

摘要:

&NA;We have conducted a 6‐wk drug withdrawal study in a group of chronic schizophrenic outpatients who had been maintained on injectable fluphenazine decanoate for at least 2 yr prior to the study. After two baseline assessments, patients were randomly assigned to two groups. The first group (holiday) received a placebo injection from a nurse who was not involved in the assessment (N = 17). The second group continued on their regular medication (N = 14). The assessment was done in a double‐blind fashion at 3 and 6 wk using the Schedule for Affective Disorders and Schizophrenia (SADS) and the Global Assessment Scale (GAS) inventories to assess symptom status. Tardive dyskinesia was measured using the Abnormal Involuntary Movement Scale (AIMS). Community adjustment was assessed by means of the self‐rated Weissman Social Adjustment Scale.We found that there were no relapses of any kind in either group of patients using the instruments mentioned above. The prevalence of tardive dyskinesia as measured by the AIMS was low, with only one patient having severe tardive dyskinesia. There was no significant worsening of the tardive dyskinesia during the drug holiday.Our study concludes that a 6‐wk drug holiday was safe in this group of chronic schizophrenic patients maintained on fluphenazine decanoate. In contrast to other studies, no cases of covert tardive dyskinesia were detected during the drug holiday.

ISSN:0271-0749    

出版商:OVID    

年代:1981

数据来源: OVID

ISSN:0271-0749    

出版商:OVID    

年代:1981

数据来源: OVID

ISSN:0271-0749    

出版商:OVID    

年代:1981

数据来源: OVID

ISSN:0271-0749    

出版商:OVID    

年代:1981

数据来源: OVID

ISSN:0271-0749    

出版商:OVID    

年代:1981

数据来源: OVID

ISSN:0271-0749    

出版商:OVID    

年代:1981

数据来源: OVID