1. |
A Farewell, a Greeting, and a Thought about Relapses in Depression |
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Journal of Clinical Psychopharmacology,
Volume 3,
Issue 1,
1983,
Page 1-1
Richard Shader,
David Greenblatt,
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ISSN:0271-0749
出版商:OVID
年代:1983
数据来源: OVID
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2. |
Psychiatric Reactions during Tricyclic Treatment of the Elderly Reconsidered |
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Journal of Clinical Psychopharmacology,
Volume 3,
Issue 1,
1983,
Page 2-6
BARNETT MEYERS,
VARDA MEI-TAL,
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摘要:
In a prospective study of all geriatric patients treated with tricyclic antidepressants over an 18-month period, a lower incidence of adverse psychiatric reactions than literature based on chart reviews has suggested was found. In only thre of the 43 patients studied (7%) did a picture consistent with toxic delirium develop. None of the seven patients with senile dementia of the Alzheimer type suffered an adverse psychiatric reaction despite having achieved therapeutic blood levels of medication. Difficultis in determining the type and pathogenesis of untoward reactions that do occur as a source of error in establishing frequency are emphasized. The relationship of such reactions to the neurobiology of aging, the central anticholinergic syndrome, and the putative role of acetylcholine in contributing to the clinical picture of senile dementia of the Alzheimer type is discussed.
ISSN:0271-0749
出版商:OVID
年代:1983
数据来源: OVID
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3. |
Blood Levels of Haloperidol in Schizophrenic Patients |
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Journal of Clinical Psychopharmacology,
Volume 3,
Issue 1,
1983,
Page 7-12
ALLA SHVARTSBURD,
HAROUTUNE DEKIRMENJIAN,
ROBERT SMITH,
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摘要:
Plasma and red blood cell levels of haloperidol were measured in psychotic patients after an acute dose of haloperiodol and during treatment with fixed doses for several weeks. There was wide variability of haloperidol plasma and red blood cell levels at a given dose and a nonlinear relationship between haloperidol dose and blood levels. The red blood cell/plasma ratio (0.40) had a narrow range among different patients. Haloperidol blood levels were not correlated with the age of the patient. Concomitant administration of benztropine mesylate did not decrease plasma haloperidol levels. Steady state plasma or red cell haloperidol levels could not be predicted from levels 24 hours after the acute dose.
ISSN:0271-0749
出版商:OVID
年代:1983
数据来源: OVID
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4. |
Prediction of Lithium Maintenance Doses Using a Single Point Prediction Protocol |
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Journal of Clinical Psychopharmacology,
Volume 3,
Issue 1,
1983,
Page 13-17
PAUL PERRY,
RANDALL PRINCE,
BRUCE ALEXANDER,
FREDERICK DUNNER,
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摘要:
Conflicting reports regarding the utility of a previously described single point prediction dosing method for lithium prompted the present study's reexamination of the relationship between a single point lithium concentration and the lithium maintenance dose. Seventeen informed, adult patients with affective illness were studied. The relationship between their 24-hour lithium concentration after a test dose and the maintenance dose was significant, hence confirming earlier reports. In addition, more confident relationships were noted when steady state range concentrations for lithium prophylaxis (0.41 to 0.89 mEq/liter) and for treatment of acute maina (0.9 to 1.27 mEq/liter) were analyzed separately. Maintenance dose predictive equations were generated for these lithium steady state ranges from a 24-hour single point level after a 1200-mg test dose. The clinical usefulness of the new relationships observed for maintenance dose prediction must await prospective testing.
ISSN:0271-0749
出版商:OVID
年代:1983
数据来源: OVID
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5. |
Urinary MHPG Excretion and Treatment with Desipramine or AmitriptylinePrediction of Response, Effect of Treatment, and Methodological Hazards |
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Journal of Clinical Psychopharmacology,
Volume 3,
Issue 1,
1983,
Page 18-27
RICHARD VEITH,
ROBERT BIELSKI,
VALERIE BLOOM,
JAN FAWCETT,
N. NARASIMHACHARI,
ROBERT FRIEDEL,
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摘要:
Urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) excretion was measured in 49 unipolar depressed outpatients to examine the relationship between pretreatment MHPG levels and therapeutic response to desipramine and amitriptyline and to determine the effects of these agents on MHPG excretion. Pretreatment MHPG excretion was greater in amitriptyline responders than amitriptyline nonresponders, but no different in desipramine responders compared to desipramine nonresponders. Pretreatment MHPG excretion did not differentiate desipramine from amitriptyline responders. Treatment for 3 weeks was associated with a decrement in MHPG excertion, particularly in the desipramine responders and combined desipramine and amitriptyline responders. Among patients within the postulated optimal desipramine plasma level range and patients with plasma amitriptyline plus nortriptyline levels > 70 ng/ml, high pretment MHPG excretion predicted therapeutic response and response was accompanied by a reduction in MHPG excretion. The interpretation of these findings is possibly confouded by the demonstration of a poor correlation (r= 0.61) between duplicate MHPG samples analyzed by a widely employed gas chromatography method and a gas chromatography/mass spectrometry technique. The methodological pitfalls encountered in the course of this investigation and their possible implications for similar studies are discussed.
ISSN:0271-0749
出版商:OVID
年代:1983
数据来源: OVID
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6. |
Lack of Efficacy of a New Antidepressant (Bupropion) in the Treatment of Panic Disorder with Phobias |
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Journal of Clinical Psychopharmacology,
Volume 3,
Issue 1,
1983,
Page 28-31
DAVID SHEEHAN,
JONATHAN DAVIDSON,
THEO MANSCHRECK,
JUDITH WYCK FLEET,
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ISSN:0271-0749
出版商:OVID
年代:1983
数据来源: OVID
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7. |
Replapse of Depression during Continuation TreatmentThree Clincal Vignettes |
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Journal of Clinical Psychopharmacology,
Volume 3,
Issue 1,
1983,
Page 32-34
SUHAYL NASR,
MOISES GAVIRIA,
MARLENE GRUPP,
PATRICIA RODGERS,
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ISSN:0271-0749
出版商:OVID
年代:1983
数据来源: OVID
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8. |
Spontaneous Ejaculations and Neuroleptics |
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Journal of Clinical Psychopharmacology,
Volume 3,
Issue 1,
1983,
Page 34-36
GABOR KEITNER,
STEVEN SELUB,
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ISSN:0271-0749
出版商:OVID
年代:1983
数据来源: OVID
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9. |
Effect of Phenelzine on the Prolapsed Mitral Valve in a Patient with Agoraphobia with Panic Attacks |
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Journal of Clinical Psychopharmacology,
Volume 3,
Issue 1,
1983,
Page 36-38
DWIGHT EVANS,
KENT KALINA,
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ISSN:0271-0749
出版商:OVID
年代:1983
数据来源: OVID
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10. |
Extreme Elevations in Plasma Norepinephrine Associated with Decreased α‐Adrenergic Responsivity in Major Depressive DisorderTwo Case Reports |
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Journal of Clinical Psychopharmacology,
Volume 3,
Issue 1,
1983,
Page 39-41
LARRY SIEVER,
DAVID PICKAR,
RAYMOND LAKE,
ROBERT COHEN,
THOMAS UHDE,
DENNIS MURPHY,
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ISSN:0271-0749
出版商:OVID
年代:1983
数据来源: OVID
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