ISSN:0096-1736    

出版商:OVID    

年代:1986

数据来源: OVID

摘要:

The nature of the interaction between smoking of occupational exposure is controversaial. in part because of lack of agreement on the definition of interaction and in part becaue of the searcity of adequate epidemiologic data. Occupational investigators have assessed interaction primarily as a departure from an additive rather than from a multiplicative model of realtive risks (or rate ratios). To determine whether smoking modifies the effect of occupational lung carcinogens, the literature was reviewed for the only our established occupational lung carcinogens for which there are data on smjoking; radion daughters, asbestos, arsenic, and chloromethyl ethers. Wehre possible, departure was assessed from both an additive (syngergism) and a multiplicative model (effect modification). Only nine studies were considred to have sufficient ample size and to provide sufficient information on tobacco use and occupational exposure to evaluate interaction. The existing data were contradictory for three of the agents studied; as bestos, radon daughters, and arsenic. Inconclusive or contradictory fidnings may result from small sample size or lack of comparability of the level of occupational or tobacco exposure. It is noteworthy that, for these four agents, whenever smoking did modify the effect of occupatioanl exposure, the lung cancer rate ratio was greater for nonsmokers (compared to nonexposed smokers). However, with the exception of chloromethykl ethers, absolute lung cancer rates were higher for smokers than nonsmokers, regardless of occupational exposure.

ISSN:0096-1736    

出版商:OVID    

年代:1986

数据来源: OVID

摘要:

Although organic solvents are essential components of an industrial economy; they are not used without risk. The relationship between excessive exposure to organic solvents and susbequent development of chronic encephalopathy has been recognized for neary 100 years.Fifteen industrial painters who underwent evaluation in an occupational health clinic for symptoms that they realted to their work were found to have a shigh prevalence of neurasthenic symptomas, most frequently, memory loss and personality change. Although neurologic and screening laboratory examinations showed no consistent abnormalitie, pshychological ests documented poor short-term memory and an array of neuropsychologic deficits. Pesonality profiles revealed depresion, anxiety, and preoccupation with somatic concerns.These fidings agree well with previous reports of “chronic painter's syndrome.” Heightened awareness among industrial physicians and prospecutive studies to evaluate existing threshold limit values and personal protective equipment requirements are indicated.

ISSN:0096-1736    

出版商:OVID    

年代:1986

数据来源: OVID

ISSN:0096-1736    

出版商:OVID    

年代:1986

数据来源: OVID

ISSN:0096-1736    

出版商:OVID    

年代:1986

数据来源: OVID

ISSN:0096-1736    

出版商:OVID    

年代:1986

数据来源: OVID